关于宫颈癌的sci论文

.....我也有兴趣知道，不过ls的是通讯嘛，没有详细介绍的。

(1) Li W, Zheng J, Deng J, You Y, Wu H, Li N, Lu J,Zhou Y*. Increased Levels of the Long Noncoding RNA POU3F3 Promote DNA Methylation in Esophageal Squamous Cell Carcinoma Cells. Gastroenterology. 146(7):1714-1726;2014 .（*通讯作者，本期封面推荐文章）(2) Wu H, Zheng J, Deng J, Hu M, You Y, Li N, Li W, Lu J, Zhou Y*. A genetic polymorphism in is associated with susceptibility to esophageal squamous cell carcinoma in Chinese populations. Carcinogenesis. 34(12):2908-17; 2013.（*通讯作者）(3) Zheng J, Deng J, Xiao M, Yang L, Zhang L, You Y, Hu M, Li N, Wu H, Li W, Lu J, Zhou Y*. A sequence polymorphism in miR-608 predicts recurrence after radiotherapy for nasopharyngeal carcinoma. Cancer Res. 73(16):5151-62; 2013. （*通讯作者）(4) Wu H, Deng J, Zheng J, You Y, Li N, Li W, Wu D, Zhou Y*. Functional polymorphisms in the CD44 gene and acute myeloid leukemia cancer risk in a Chinese population. Mol Carcinog. 2013 Sep 4. [Epub ahead of print] （*通讯作者）(5) Zheng J, Deng J, Jiang L, Yang L, You Y, Hu M, Li N, Wu H, Li W, Li H, Lu J, Zhou Y*. Heterozygous genetic variations of FOXP3 in elevate breast cancer risk in Chinese population via skewed X-chromosome inactivation. Hum Mutat. 34(4):619-28; 2013.（*通讯作者）(6) You Y, Deng J, Zheng J, Hu M, Li N, Wu H, Li W, Lu J, Zhou Y*. IL-21 gene polymorphism is associated with the prognosis of breast cancer in Chinese populations. Breast Cancer Res Treat. 137(3):893-901;2013.（*通讯作者）(7) Li N, Xu Y, Zheng J, Jiang L, You Y, Wu H, Li W, Wu D, Zhou Y*. NBS1 rs1805794G>C polymorphism is associated with decreased risk of acute myeloid leukemia in a Chinese population. Mol Biol Rep. 40(5):3749-56; 2013.（*通讯作者）(8) Zheng J, Jiang L, Zhang L, Yang L, Deng J, You Y, Li N, Wu H, Li W, Lu J, Zhou Y*. Functional genetic variations in the IL-23 receptor gene are associated with risk of breast, lung and nasopharyngeal cancer in Chinese populations. Carcinogenesis. 33(12):2409-16; 2012.（*通讯作者）(9) Jiang L, Deng J, Zhu X, Zheng J, You Y, Li N, Wu H, Lu J, Zhou Y*. CD44 rs13347 C>T polymorphism predicts breast cancer risk and prognosis in Chinese populations. Breast Cancer Res. 14(4):R105; 2012.（*通讯作者）(10) Hu M, Jian L, Zhang L, Zheng J, You Y, Deng J, Li H, Zhou Y*. Functional polymorphism in the EpCAM gene is associated with occurrence and advanced disease status of cervical cancer in Chinese population. Mol Biol Rep. 39(7):7303-9;2012.（*通讯作者）(11) Hu Y, Jiang L, Zheng J, You Y, Zhou Y*, Jiao S. Association between the p73 exon 2 G4C14-to-A4T14 polymorphism and cancer risk: a meta-analysis. DNA Cell Biol. 31(2):230-7; 2012.（*通讯作者）(12) Zheng J, Chen S, Jiang L, You Y, Wu D, Zhou Y*. Functional genetic variations of cyclooxygenase-2 and susceptibility to acute myeloid leukemia in a Chinese population. Eur J Haematol. 87(6):486-93; 2011.（*通讯作者）(13) Zheng J, Liu B, Zhang L, Jiang L, Huang B, You Y, Jiang Q, Zhang S, Lu J, Zhou Y*. The protective role of polymorphism MKK4-1304 T>G in nasopharyngeal carcinoma is modulated by Epstein-Barr virus' infection status. Int J Cancer. 130(9):1981-90;2012.（*通讯作者）(14) Zheng J, Zhang C, Jiang L, You Y, Liu Y, Lu J, Zhou Y*. Functional NBS1 polymorphism is associated with occurrence and advanced disease status of nasopharyngeal carcinoma. Mol Carcinog. 50(9):689-96; 2011.（*通讯作者）(15) Jiang L, Zhou P, Sun A, Zheng J, Liu B, You Y, Zhang C, Wu D, Zhou Y*. Functional variant (-1304T>G) in the MKK4 promoter is associated with decreased risk of acute myeloid leukemia in a southern Chinese population. Cancer Sci. 102(8):1462-8; 2011.（*通讯作者）(16) Yu X, Zhang C, Sun A, Jiang L, Zheng J, You Y, Wu D, Zhou Y*. Genetic variations in CD14 promoter and acute lymphoblastic leukemia susceptibility in a Chinese population. DNA Cell Biol. 30(10):777-82;2011.（*通讯作者）(17) Jiang L, Liang J, Jiang M, Yu X, Zheng J, Liu H, Wu D, Zhou Y*. Functional polymorphisms in the NBS1 gene and acute lymphoblastic leukemia susceptibility in a Chinese population. Eur J Haematol. 86(3):199-205; 2011.（*通讯作者）(18) Jiang L, Zhang C, Li Y, Yu X, Zheng J, Zou P, Li Y, Bin X, Lu J, Zhou Y*. A non-synonymous polymorphism Thr115Met in the EpCAM gene is associated with an increased risk of breast cancer in Chinese population. Breast Cancer Res Treat. 126(2):487-95;2011.（*通讯作者）(19) Zheng J, Zhang C, Jiang L, You Y, Liu Y, Lu J, Zhou Y*. Functional NBS1 polymorphism is associated with occurrence and advanced disease status of nasopharyngeal carcinoma. Mol Carcinog. 50(9):689-96; 2011.（*通讯作者）(20) Xu J, He X, Jin L, Jiang L, Zhou Y*, Kang Z, Peng R, Lee ST. A protein-based electrochemical method for label-free characterization of sequence-specific protein-DNA interactions. Electrochim Acta. 56:5759-5765; 2011.（*通讯作者）(21) Jiang L, Zhou P, Sun A, Zheng J, Liu B, You Y, Zhang C, Wu D, Zhou Y*. Functional variant (-1304T>G) in the MKK4 promoter is associated with decreased risk of acute myeloid leukemia in a southern Chinese population. Cancer Sci. 102(8):1462-8; 2011.（*通讯作者）(22) Yu X, Zhang C, Sun A, Jiang L, Zheng J, You Y, Wu D, Zhou Y*. Genetic variations in CD14 promoter and acute lymphoblastic leukemia susceptibility in a Chinese population. DNA Cell Biol. 30(10):777-82;2011.（*通讯作者）(23) Jiang L, Liang J, Jiang M, Yu X, Zheng J, Liu H, Wu D, Zhou Y*. Functional polymorphisms in the NBS1 gene and acute lymphoblastic leukemia susceptibility in a Chinese population. Eur J Haematol. 86(3):199-205; 2011.（*通讯作者）(24) Zheng J, Yu X, Jiang L, Xiao M, Bai B, Lu J, Zhou Y*. Association between the Cytotoxic T-lymphocyte antigen 4 +49G > A polymorphism and cancer risk: a meta-analysis. BMC Cancer. 10:522; 2010.（*通讯作者）(25) Gao Y, He Y, Ding J, Wu K, Hu B, Liu Y, Wu Y, Guo B, Shen Y, Landi D, Landi S, Zhou Y*, Liu H. An insertion/deletion polymorphism at miRNA-122-binding site in the interleukin-1alpha 3' untranslated region confers risk for hepatocellular carcinoma. Carcinogenesis. 30(12):2064-9;2009.（*通讯作者）(26) Sun T, Zhou Y*, Yang M, Hu Z, Tan W, Han X, Shi Y, Yao J, Guo Y, Yu D, Tian T, Zhou X, Shen H, Lin D. Functional genetic variations in CTLA-4 and susceptibility to multiple types of cancer. Cancer Res. 2008 68:7025-7034.（*共同第一作者） (27) Sun T, Zhou Y*, Li H, Han X, Shi Y, Wang L, Miao X, Tan W, Zhao D, Zhang X, Guo Y, Lin D. FASL -844C polymorphism is associated with increased activation-induced T cell death and risk of cervical cancer. J Exp Med. 2005 202:967-974.（*共同第一作者）(28) Zhou Y, Yu C, Miao X, Wang Y, Tan W, Sun T, Zhang X, Xiong P, Lin D. Functional haplotypes in the promoter of matrix metalloproteinase-2 and lung cancer susceptibility. Carcinogenesis. 2005 26:1117-1121.(29) Yu C, Zhou Y*, Miao X, Xiong P, Tan W, Lin D. Functional haplotypes in the promoter of matrix metalloproteinase-2 predict risk of the occurrence and metastasis of esophageal cancer. Cancer Res. 2004 64:7622-7628.（*共同第一作者）(30) Zhou Y, Yu C, Miao X, Tan W, Liang G, Xiong P, Sun T, Lin D. Substantial reduction in risk of breast cancer associated with genetic polymorphisms in the promoters of the matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 genes. Carcinogenesis. 2004 25:399-404.(31) Yang L, Yang X, Ji W, Deng J, Qiu F, Yang R, Fang W, Zhang L, Huang D, Xie C, Zhang H, Zhong N, Ran P, Zhou Y, Lu J. Effects of a Functional Variant >C in Snai1 on Risk of Two Contextual Diseases. Chronic Obstructive Pulmonary Disease and Lung Cancer. Am J Respir Crit Care Med. 189(2):139-48; 2014.(32) Yang L, Liu B, Qiu F, Huang B, Li Y, Huang D, Yang R, Yang X, Deng J, Jiang Q, Zhou Y,Lu J. The effect of functional MAPKAPK2 copy number variation CNV-30450 on elevating nasopharyngeal carcinoma risk is modulated by EBV infection. Carcinogenesis. 35(1):46-52; 2014.(33) Yang R, Yang L, Qiu F, Zhang L, Wang H, Yang X, Deng J, Fang W, Zhou Y, Lu J. Functional genetic polymorphisms in PP2A subunit genes confer increased risks of lung cancer in southern and eastern Chinese. PLoS One. 8(10):e77285; 2013.(34) Wu C, Li D, Jia W, Hu Z, Zhou Y, Yu D, Tong T, Wang M,Lin D, Qiao Y, Zhou Y, Chang J, Zhai K, Wang M, Wei L, Tan W, Shen H, Zeng Y,Lin D. Genome-wide association study identifies common variants in SLC39A6 associated with length of survival in esophageal squamous-cell carcinoma. Nat Genet. 45(6):632-8; 2013.(35) Qiu F, Yang L, Fang W, Li Y, Yang R, Yang X, Deng J, Huang B, Xie C, Zhou Y,Lu J. A functional polymorphism in the promoter of ERK5 gene interacts with tobacco smoking to increase the risk of lung cancer in Chinese populations. Mutagenesis. 28(5):561-7; 2013.(36) Cheng M, Yang L, Yang R, Yang X, Deng J, Yu B, Huang D, Zhang S, Wang H, Qiu F, Zhou Y,Lu J. A microRNA-135a/b binding polymorphism in CD133 confers decreased risk and favorable prognosis of lung cancer in Chinese by reducing CD133 expression. Carcinogenesis. 34(10):2292-9; 2013.(37) Wu C, Chang J, Ma B, Miao X, Zhou Y, Liu Y, Li Y, Wu T, Hu Z, Shen H, Jia W, Zeng Y,Lin D, Kraft P. The case-only test for gene-environment interaction is not uniformly powerful: an empirical Epidemiol. 37(4):402-7; 2013.(38) Xie C, Yang L, Yang X, Yang R, Li Y, Qiu F, Chen M, Fang W, Bin X, Deng J, Huang D, Liu B, Zhou Y, Lu J. Sipa1 promoter polymorphism predicts risk and metastasis of lung cancer in Chinese. Mol Nov; [Epub ahead of print](39) Yang L, Liu B, Huang B, Deng J, Li H, Yu B, Qiu F, Cheng M, Wang H, Yang R, Yang X, Zhou Y, Lu J. A functional copy number variation in WWOX gene is associated with lung cancer risk in Chinese. Hum Mol Genet. 22(9):1886-94; 2013.(40) Huang D, Yang L, Liu Y, Zhou Y, Guo Y, Pan M, Wang Y, Tan Y, Zhong H, Hu M, Lu W, Ji W, Wang J, Ran P, Zhong N, Zhou Y, Lu J. Functional polymorphisms in NFκB1/IκBα predict risks of chronic obstructive pulmonary disease and lung cancer in Chinese. Hum Genet. 2013 Jan 16. [Epub ahead of print](41) Huang L, Wu C, Yu D, Wang C, Che X, Miao X, Zhai K, Chang J, Jiang G, Yang X, Cao G, Hu Z, Zhou Y, Zuo C, Wang C, Zhang X,Zhou Y, Yu X, Dai W, Li Z, Shen H, Liu L, Chen Y, Zhang S, Wang X, Liu Y, Sun M, Cao W, Gao J, Ma Y, Zheng X, Cheung ST, Jia Y, Tan W, Wu T, Lin D. Identification of common variants in BRCA2 and MAP2K4 for susceptibility to sporadic pancreatic cancer. Carcinogenesis. 34(5):1001-5; 2013.(42) Jin G, Ma H, Wu C, Dai J, Zhang R, Shi Y, Lu J, Miao X, Wang M, Zhou Y, Chen J, Li H, Pan S, Chu M, Lu F, Yu D, Jiang Y, Dong J, Hu L, Chen Y, Xu L, Shu Y, Pan S, Tan W, Zhou B, Lu D, Wu T, Zhang Z, Chen F, Wang X, Hu Z, Lin D, Shen H. Genetic variants at and are associated with risk of multiple cancers in Han Chinese. Am J Hum Genet. 91(5):928-34; 2012.(43) Yang L, Qiu F, Lu X, Huang D, Ma G, Guo Y, Hu M, Zhou Y, Pan M, Tan Y, Zhong H, Ji W, Wei Q, Ran P, Zhong N, Zhou Y, Lu J. Functional polymorphisms of CHRNA3 predict risks of chronic obstructive pulmonary disease and lung cancer in Chinese. PLoS One. 7(10):e46071;2012.(44) You Y, Deng J, Zheng J, Jiang L, Li N, Wu H, Li W, Lu J, Zhou Y, Ni B. Functional polymorphisms in PIN1 promoter and esophageal carcinoma susceptibility in Chinese population. Mol Biol Rep. 40(2):829-38;2013.(45) Wu C, Kraft P, Zhai K, Chang J, Wang Z, Li Y, Hu Z, He Z, Jia W, Abnet CC, Liang L, Hu N, Miao X, Zhou Y, Liu Z, Zhan Q, Liu Y, Qiao Y, Zhou Y, Jin G, Guo C, Lu C, Yang H, Fu J, Yu D, Freedman ND, Ding T, Tan W, Goldstein AM, Wu T, Shen H, Ke Y, Zeng Y, Chanock SJ, Taylor PR, Lin D. Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions. Nat Genet. 44(10):1090-7;2012.(46) Liu B, Yang L, Huang B, Cheng M, Wang H, Li Y, Huang D, Zheng J, Li Q, Zhang X, Ji W, Zhou Y, Lu J. A functional copy-number variation in MAPKAPK2 predicts risk and prognosis of lung cancer. Am J Hum Genet. 91(2):384-90; 2012.(47) Huang D, Qiu F, Yang L, Li Y, Cheng M, Wang H, Ma G, Wang Y, Hu M, Ji W, Zhou Y, Lu J. The polymorphisms and haplotypes of WWOX gene are associated with the risk of lung cancer in southern and eastern Chinese populations. Mol Carcinog. 2012 Jun 12. [Epub ahead of print](48) Yang M, Sun T, Zhou Y, Wang L, Liu L, Zhang X, Tang X, Zhou M, Kuang P, Tan W, Li H, Yuan Q, Yu D. The functional cytotoxic T lymphocyte-associated Protein 4 49G-to-A genetic variant and risk of pancreatic cancer. Cancer. 118(19):4681-6; 2012.(49) Huang B, Liu B, Yang L, Li Y, Cheng M, Huang D, Wang H, Zhang X, Zheng J, Li Q, Ji W, Zhou Y, Lu J. Functional genetic variants of c-Jun and their interaction with smoking and drinking increase the susceptibility to lung cancer in southern and eastern Chinese. Int J Cancer. 131(5):E744-58; 2012.(50) Yang L, Li Y, Cheng M, Huang D, Zheng J, Liu B, Ling X, Li Q, Zhang X, Ji W, Zhou Y, Lu J. A functional polymorphism at microRNA-629-binding site in the 3'-untranslated region of NBS1 gene confers an increased risk of lung cancer in Southern and Eastern Chinese population. Carcinogenesis. 33(2):338-47;2012.(51) Wu C, Miao X, Huang L, Che X, Jiang G, Yu D, Yang X, Cao G, Hu Z, Zhou Y, Zuo C, Wang C, Zhang X, Zhou Y, Yu X, Dai W, Li Z, Shen H, Liu L, Chen Y, Zhang S, Wang X, Zhai K, Chang J, Liu Y, Sun M, Cao W, Gao J, Ma Y, Zheng X, Cheung ST, Jia Y, Xu J, Tan W, Zhao P, Wu T, Wang C, Lin D. Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations. Nat Genet. 44(1):62-6; 2011.(52) Shi Y, Hu Z, Wu C, Dai J, Li H, Dong J, Wang M, Miao X, Zhou Y, Lu F, Zhang H, Hu L, Jiang Y, Li Z, Chu M, Ma H, Chen J, Jin G, Tan W, Wu T, Zhang Z, Lin D, Shen H. A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at and . Nat Genet. 43(12):1215-8;2011.(53) Lu J, Yang L, Zhao H, Liu B, Li Y, Wu H, Li Q, Zeng B, Wang Y, Ji W, Zhou Y. The polymorphism and haplotypes of PIN1 gene are associated with the risk of lung cancer in Southern and Eastern Chinese populations. Hum Mutat. 32(11):1299-308; 2011.(54) Wu C, Hu Z, He Z, Jia W, Wang F, Zhou Y, Liu Z, Zhan Q, Liu Y, Yu D, Zhai K, Chang J, Qiao Y, Jin G, Liu Z, Shen Y, Guo C, Fu J, Miao X, Tan W, Shen H, Ke Y, Zeng Y, Wu T, Lin D. Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations. Nat Genet. 43(7):679-84; 2011.(55) Ding J, Gao Y, He Y, Zhou Y, Huang M, Liu H. Screening SNPs residing in the microRNA-binding sites of hepatocellular carcinoma related J Data Min Bioinform. 5(1):1-21; 2011.(56) Lin D, Liu C, Xue M, Liu R, Jiang L, Yu X, Bao G, Deng F, Yu M, Ao J, Zhou Y, Wu D, Liu H. The role of interleukin-15 polymorphisms in adult acute lymphoblastic leukemia. PLoS One. 5(10):e13626; 2010.(57) Liu P, Jaffar J, Zhou Y, Yang Y, Hellström I, Hellström KE. Inhibition of TGFbeta1 makes nonimmunogenic tumor cells effective for therapeutic vaccination. J Immunother. 32(3):232-9; 2009.(58) Zhang B, Sun T, Xue L, Han X, Zhang B, Lu N, Shi Y, Tan W, Zhou Y, Zhao D, Zhang X, Guo Y, Lin D. Functional polymorphisms in FAS and FASL contribute to increased apoptosis of tumor infiltration lymphocytes and risk of breast cancer. Carcinogenesis. 2007 28:1067-1073. (59) Yang Y, Yang S, Ye Z, Jaffar J, Zhou Y, Cutter E, Lieber A, Hellström I, Hellström KE. Tumor cells expressing anti-CD137 scFv induce a tumor-destructive environment. Cancer Res. 2007 67:2339-2344.(60) Hao B, Miao X, Li Y, Zhang X, Sun T, Liang G, Zhao Y, Zhou Y, Wang H, Chen X, Zhang L, Tan W, Wei Q, Lin D, He F. A novel T-77C polymorphism in DNA repair gene XRCC1 contributes to diminished promoter activity and increased risk of non-small cell lung cancer. Oncogene. 2006 25:3613-3620.(61) Zhang X, Miao X, Guo Y, Tan W, Zhou Y, Sun T, Wang Y, Lin D. Genetic polymorphisms in cell cycle regulatory genes MDM2 and TP53 are associated with susceptibility to lung cancer. Hum Mutat. 2006 27:110-117.(62) Zhang X, Miao X, Sun T, Tan W, Qu S, Xiong P, Zhou Y, Lin D. Functional polymorphisms in cell death pathway genes FAS and FASL contribute to risk of lung cancer. J Med Genet. 2005 42:479-484.(63) Tan W, Miao X, Wang L, Yu C, Xiong P, Liang G, Sun T, Zhou Y, Zhang X, Li H, Lin D. Significant increase in risk of gastroesophageal cancer is associated with interaction between promoter polymorphisms in thymidylate synthase and serum folate . 2005 26:1430-1435.(64) Sun T, Miao X, Wang J, Tan W, Zhou Y, Yu C, Lin D. Functional Phe31Ile polymorphism in Aurora A and risk of breast carcinoma. Carcinogenesis. 2004 25:2225-2230.(65) Liang G, Miao X, Zhou Y, Tan W, Lin D. A functional polymorphism in the SULT1A1 gene (G638A) is associated with risk of lung cancer in relation to tobacco smoking. Carcinogenesis. 2004 25:773-778.(66) 李华，郭红燕，孙瞳，周翊峰，林东昕，章文华，乔杰。Fas和Fas配体基因启动子单核苷酸多态性与子宫颈癌的发病风险。《中华肿瘤杂志》2009 31: 38-41.(67) 张雪梅，缪小平，谭文，曲世宁，孙瞳，周翊峰，林东昕。亚甲基四氢叶酸还原酶基因遗传变异与肺癌。《中国医学科学院学报》2005 27:700-703.(68) 冯飞跃，梁刚，吕文富，缪小平，于春媛，谭文，周翊峰，孙瞳，康滨，周彤，潘凯枫，张联，林东昕。尿苷二磷酸葡糖醛酸转移酶1A7基因多态基础研究。《癌症》2005 24:1085-1090.(69) 张雪梅，缪小平，熊萍，于春媛，谭文，曲世宁，孙瞳，周翊峰，林东昕。基质金属蛋白酶2和9功能性单核苷酸多态与胃癌。《癌症》2004 23:1233-1237

HeLa细胞是一种常用于构建小鼠宫颈癌模型的细胞，被广泛用于细胞培养、生物实验以及肿瘤研究中。HeLa细胞的出现为宫颈癌的治疗指明了道路，在探讨宫颈癌治疗药物和方法时，常会研究化合物对宫颈癌HeLa细胞侵袭和迁移能力以及对宫颈癌肿瘤抑制模型小鼠的存活的影响。 在人类生物学中广泛应用的细胞系——HeLa细胞，来自于1951年，源自一名美国妇女的子宫颈癌细胞，现在已经成为医学研究中非常重要的工具。人类细胞由于分裂次数有限，难以实现长期留存，而肿瘤HeLa细胞具有顽强的生命力和繁殖力，因而成为科学家获得的第一个人类细胞系。HeLa细胞株是由正常子宫颈细胞被一种人类乳突状瘤病毒转型成癌细胞的，而且和正常子宫颈癌细胞有许多不同，此细胞显角蛋白免疫沉淀染色阳性，包含HPV-18序列，有正常水平的pRB表达和p53的低水平表达。人乳头瘤病毒（HPV）在宫颈癌发病过程中起着重要的作用，HPV16和HPV18是HPV的两个重要亚型。 从1952年至今，HeLa细胞促成了超过6万篇论文，其中涉及脊髓灰质炎疫苗的研发，和导致两项诺贝尔奖的研究。，利用HeLa细胞构建小鼠宫颈癌模型的研究也是数不胜数。如有研究者发现，用绿色荧光蛋自标记的人宫颈癌细胞Hela建立的小鼠宫颈癌模型可以为人宫颈癌研究提供理想的实验材料，应用小动物活体成像系统能够客观定量评价活的肿瘤细胞在动物体内的生长情况，而不是肿瘤体积的变化。在抗肿瘤药物药效学初步筛选或初步有效性的评价中常采用小鼠肿瘤移植模型来进行体内试验。美迪西可以根据客户的需求提供各种有效的同种肿瘤移植模型，用来检测药物的有效性。常规的肿瘤疾病有：乳腺癌、肺癌、结肠癌、肾癌、DLBCL淋巴瘤等，通过大小鼠、仓鼠等进行动物实验。 利用Hela细胞构建的小鼠宫颈癌模型还可以探讨化合物对结肠癌的作用机制。如有研究者探讨了黑蒜提取液对宫颈癌HeLa细胞移植瘤辐射增敏及保护机制，通过构建宫颈癌HeLa细胞小鼠皮下移植瘤模型,并将其随机分成4组,空白对照组、γ照射组、黑蒜组、黑蒜+γ照射组。将其分别用生理盐水、γ射线照射、黑蒜提取液、黑蒜提取液联合γ射线照射来进行处理,然后对各组移植瘤生长的速度进行观察[1]。通过实验发现黑蒜提取液对HeLa细胞移植瘤具有辐射增敏作用,通过增强免疫功能,提高外周血白细胞计数和机体抗氧化能力,以提高对机体的辐射保护作用。 也有研究者探讨了莪术对人宫颈癌细胞的增殖及免疫功能的影响[2]。研究者将50只裸鼠移植瘤模型简单随机分成5组，分别给予不同的处理，观察小鼠的免疫功能及癌组织的病理结果变化；用 M TT 方法检测莪术水煎液对宫颈癌 Hela 细胞的抑制作用。研究结果发现莪术具有抑制宫颈癌细胞的生长，促进癌细胞凋亡等作用。 子宫颈癌是妇科最常见的恶性肿瘤之一，利用Hela细胞通过裸鼠成瘤实验建立小鼠宫颈癌模型，通过观察化合物对裸鼠移植瘤的影响，可以为抗肿瘤药物的研发奠定基础。总之Hela细胞系无论是在过去还是未来，都是医学研究的一项重要工具。 [1]黑蒜提取液对宫颈癌HeLa细胞移植瘤辐射增敏及保护机制研究[J]. [2]莪术对人宫颈癌Hela细胞增殖及免疫功能的影响[J].