burns杂志期刊号

先去ncbi再去相关全文数据库里找，我在艾斯维尔找的第一篇第二篇给你个网址第三篇外网没有我是放在pdf,贴出来太长，你又没邮箱,你看看是不是这，是的话留个邮箱Synthesis and Antiinflammatory Activity of Coumarin Derivatives†,‡Christos A. Kontogiorgis and Dimitra J. Hadjipavlou-Litina*Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki,54124, Thessaloniki, GreeceReceived March 1, 2005The synthesis of several coumarin Mannich bases is described. The structures of the synthesizedcompounds were confirmed by spectral and elemental analysis. Their lipophilicity wasdetermined experimentally by RPTLC method. All compounds were evaluated for theirantiinflammatory and antioxidant activity and for their ability to inhibit in vitro lipoxygenase.The derivatives were found to present antioxidant and antiinflammatory activities. The testedderivatives inhibited carraggeenin-induced hind paw edema. They also significantly suppressedthe arthritis induced by Freund’s adjuvant. Compound 10, the most active in vivo, was foundto possess protective properties against adjuvant-induced arthritis in rats. The biological invitro activities were concentration dependent. Hydrophilicity, the presence of a free 7-OH, andsteric requirements for the substituent at position 8 are the most important factors in termsof SAR. An attempt was made to correlate several physicochemical properties of the moleculeswith their in vivo/in vitro activity.IntroductionInflammation is a complex phenomenon involvinginterrelationships humoral and cellular reactions througha number of inflammatory mediators. It is a usualsymptom covering different pathologies, and there arestill many questions to be answered in order to understandthe inflammatory process as well as a need forbetter-tolerated and more efficient nonsteroidal antiinflammatorydrugs. In the pathways of the inflammatoryprocess, the implication of free radicals is particularlyimportant. It has also been reported that antiinflammatorydrugs may be effective in the prevention of freeradical-mediated damage.1Coumarins have been reported to have multiplebiological activities.2 They have been used to treat suchdiverse ailments as cancer, burns, brucellosis, andcardiovascular and rheumatic diseases.3 The coumarinmolecule has been shown to possess unique antiedemaand antiinflammatory activities. Thus, coumarin derivativescould be particularly effective in the treatmentof all high protein edemas.4-6 Various coumarin-relatedderivatives are recognized as inhibitors of the lipoxygenaseand cyclooxygenase pathways of arachidonatemetabolism7-9 but also of neutrophile-dependent superoxideanion generation.10 Several natural or syntheticcoumarins with various hydroxyl and other substituentswere found to inhibit lipid peroxidation and to scavengehydroxyl radicals and superoxide anion11 and to influence

Mission:The public welfare recruits to stick a designTopic:Smoke cigarette a harmful healthAccording to WHO statistics, global have 500 myriad peoples around annually currently die because of smoking cigarette, the tobacco has become after the high blood pressure of No.2th"cutthroat".WHO estimate, if don't take in to control, every year smokes cigarette a death-dealing number to increase probably up to 2020100%.Have in the world 1,300,000,000 the smoke the people 6.500,000,000 people would because of smoke cigarette but lead die early. Smoke cigarette for good elephant chronic suicide, at slowly burnable life, smoke cigarette endanger of not only is a smoker only oneself of health, circumferential others also would because of passive smoke cigarette but influence healthy body. Design a project:The coal ball ratio which uses to burn to the utmost makes fragmented and disorganized smoke lung, if can not compare with knock to ring a clock, the result is so terrible we dares not thinks about it, the result of the end is slowly a to become an ashes. Design a project:The withered leaf who uses in disastrous state compares to make fragmented and disorganized smoke lung, the chief criminal will escape and look for next habitat.Please cherish life for the sake of oneself and the others.

Mandate: Community Poster Design Subject: smoking harmful to health According to WHO statistics, at present, the world every year about 25 million people died because of smoking, tobacco has become the second after following hypertension, "killer." WHO estimates that if it does not control, that by the year 2020 the number of deaths each year of smoking are likely to increase doubled. In the world of 1.3 billion smokers, 650 million people will die prematurely because of smoking. Smoking seems to slow suicide, in the slowly burning life, not only the smokers that smoking is hazardous to my health, will be around other people affected by passive smoking and health. Design: Using the briquettes burn out than to the fragmentation of breathing lung, and if we do not sound the alarm in time, the consequences would be unthinkable, the final result is that slowly burned. Design: Baikongqianchuang fragmentation of the leaves to smoke than the lung, the culprit will escape and find a habitat. In order to themselves and others, cherishing life.以上是用google翻译的，它会分析到最正确的答案，谢谢

《致谄媚者》And would some Power give us the giftTo see ourselves as others see us!It would from many a blunder free us,And foolish notion:What airs in dress and gait would leave us,And even devotion!翻译：你尽夸结交了多少权贵，说昨夜同侯爵碰杯但跳蚤毕竟是跳蚤，即使它爬进了王后的发缝。

任务：公益招贴设计 Mission : Community poster design主题：吸烟有害健康 Subject : Smoking harms health据世卫组织统计，目前全球每年约有500万人因吸烟而死亡，烟草已成为继高血压之后的第二号“杀手”。In accordance with the studies from the World Health Organization, there are 500 million die due to smoking around the world every year, the tobacco has became the 2nd killer after the high blood pressure.世卫组织估计， 如果不加以控制，到2020年每年吸烟致死的人数有可能增加一倍。WHO estimates that if the tobacco smoking was not controlled, then the numbers of death shall be doubled annually as of year 2020.在全球13亿烟民中，有6．5亿人会因为吸烟而过早死亡。 Among 13 billion smokers, there are 6.5 billion smokers shall suffer early death.吸烟就好象慢性自杀，在慢慢的燃烧生命，吸烟危害的不仅仅是吸烟者本人的健康，周围的其他人也会因被动吸烟而影响身体健康。 Smoking burns life, the smokers was committed suicide gradually, smoking not only harming the health of the smokers, but caused health hazard to the passive smokers around the smoker as well.设计方案：用烧尽的煤球比作支离破碎的烟肺，如果不及时敲响警钟，后果不堪设想，最后的结果就是慢慢燃成灰烬。 Design criteria : Using the burning charcoal to represent the smoker's fragile lung, if the alarm was not pulled immediately, the consequense shall be suffered, the charcoal shall burn into ashes.设计方案：用百孔千疮的枯叶比作支离破碎的烟肺，罪魁祸首就会逃离并寻找下一个栖息地。为了自己和他人，请珍爱生命。Design criteria : Using dried leaves to represent the smoker's fragile lung. quit smoking to get rid of the killers, the killers shall get away to somewhere else. Please appreciate your life for yourselves and the family.

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