Objective: the curative effect of continuous paravertebral nerve block analgesia evaluation after nephrectomy. Methods: the quasi simple nephrectomy in 60 patients, ASA grade I or II grade, age 30 to 65 years of age, body weight 45 ~ 80 kg, sex not limited. Using the method of random number table, the patients were divided into 2 groups: control group (group CEA) and continuous paravertebral nerve block group (group PVB), 30 cases of each group. The two groups were continuous infusion of ropivacaine 250ml, and the use of intravenous morphine patient-controlled analgesia assisted. After 6, 12, 24 and 48 h, respectively, blood gas, and to assess the quiet and motion state of the VAS scores, statistics at 48 h after operation, two groups of patients with total amount of morphine and complications of case number. Results: compared with CEA group, PVB group, PaO2 increased, PaCO2 decreased, in a quiet state no difference in VAS score, significant differences in the state of motion, reduce the number of cumulative dosage of morphine, nausea, vomiting, skin itching, orthostatic hypotension, postoperative anal exhaust time interval to first short (P < ). Conclusion: open nephrectomy after using PVB analgesia and CEA analgesia can reduce postoperative morphine consumption, low rate of complications.