I and Bioinformatics
This semester elective courses - bioinformatics coming to an end. Before class, I always thought that the basic course in bioinformatics is just talking about human or animal genes, as well as differences between species gene. However, after so many weeks of classes, so I understand, "bioinformatics" and I did not imagine so simple, so "lower."Simply put, bioinformatics in genomics research related to biological information acquisition, processing, storage, distribution, analysis and interpretation. Including two meanings, one massive data collection, collation and service, which is manage the data; the other is from the discovery of new law, which is good use of these data. Specifically, bioinformatics is the genomic DNA sequence information analysis as a source to find the genomic sequence on behalf of protein and RNA gene coding region; at the same time, to clarify information in real terms in the genome there are a lot of non-coding regions, and deciphering hidden in DNA sequences The language law of inheritance; On this basis, summarize, organize and Genomic language information release and its regulation transcriptional profiling and data related protein spectrum, thus recognizing metabolism, growth, differentiation and evolution of the law.
In this brief lesson several times, under the leadership of teachers, I learned a lot about bioinformatics, including: sequence alignment, analysis and prediction of protein structure alignment, gene identification studies non-coding regions, the genetic code origin, structure-based drug design.
For example, sequence alignment, the basic issue is to compare two or more symbol sequence similarity or
Dissimilarity. From the original intention of the biological point of view, this issue contains the following meaning: The complete sequence of the DNA sequence reconstructed from the overlapping fragments. Determine the physical and genetic maps from probe data stored in a variety of experimental conditions, traversal and comparison of DNA sequences in the database to compare two or more sequences in the database similarity search-related sequences and nucleotide sequences of continuous search insert information generated model to identify sequence of the protein and DNA sequence composition than in considering the biological characteristics of DNA sequences, such as the sequence occurs locally, deletion (referred to as the first two indel) and alternative sequence of the objective function to obtain sequences Set the minimum distance between the mutation and or maximum weighted similarity and alignment methods include the global alignment, local alignment, gap penalties.
And prediction of protein structure alignment is a more fundamental issue two or more protein molecules spatial structure similarity or dissimilarity. Structure and function of proteins is closely related, it is generally believed, with similar functional protein structure generally similar. Proteins are long chains composed of amino acids in length from 50 to 1000 ~ 3000AA (Amino Acids), proteins having a variety of functions, such as enzymes, material storage and transport, signal transduction, antibodies and the like. The sequence of amino acids determines the inherent three-dimensional structure of the protein. It is generally believed that there are four different protein structures. Justification study of protein structure and prediction is: can understand the function of biological medicine, looking dockingdrugs goal to get better crop genetic engineering in agriculture, use of enzyme synthesis industry. Assumptions protein three-dimensional structural studies are inherently three-dimensional structure and amino acid sequence of correspondence (not necessarily all true), it can be used to explain the physics of minimum energy.
Bioinformatics are numerous, interdisciplinary computer science and mathematics used in molecular biology and the formation of bioinformatics genomics research has become a powerful research tool essential. In China, bioinformatics with the commencement of research on the human genome has just started, but has shown a momentum of vigorous development. Many research institutes have started or are ready to start research work in this area. Bioinformatics genomics research as a powerful weapon, is widely used to speed up the process of finding a new gene in order to achieve the "useful" first to register new gene patent purposes. Bioinformatics highly developed in the future, it will, and our daily lives are closely related. So you can draw a blueprint to imagine: the civilian population each year to the hospital for a regular check, only need to provide a drop of blood, can not see where you have all kinds of machinery to express the amount of all your genes and proteins The expression levels of all of the information and so much more measured out, and the doctor across from you computer display that you may have the disease and its prevention, or are you
The horse streptococci(the Streptococcus equi) belong to the 兰 surname germ for cent of the Cs streptococci, include the horse streptococci MA3 YA3 ZHONG3 (Streptococcus. equi subsp. Equi),the horse streptococci monster epidemic disease second kind(S. equi subsp. Zooepidemicus)with horse streptococci MA3 YA3 ZHONG3 (S. equi subsp. equisi milis).That germ can pass external injury,surgical operation,or cure etc. the path infect various animals, causing diseases, such as septicemia Sepsis,meningitis Encephalitis and mastitis(Mastitis)...etc..Its particular gene expression outcome is pathogenic(Pathogenicity) to germ to have special meaning.
Study gene, be in order to understand its function and expression and adjust to control a way.The information of make use of the living creature's learn(Bioinformatics) can adjust to control to carry on the estimate and analysis to the function and expression of the gene, the province goes to a trivial experiment to investigate, providing the instruction direction for the experiment verification.The function and sequence of the gene are closely-related, when the likeness that is a sequence exceeds certain scope, they carry out same function probably, pass will don't know the function sequence with have already known the contrast of the function sequence, if their likeness is higher and then can predict a sequence to correspond function.
The purpose of this topic research is to be learn with the living creature information Be the theories foundation usage tool software with according to WEB on-line service to some a do not know the horse streptococci gene carry on a series of analysis, the result integrate, predicting the function of this gene expression outcome thus.
The horse streptococci P50 gene sequence length is a 100 BPs, the whole gene has a to open all of the reading frame(ORF)s to grow a 90 BPs, coding 100 amino acids 残基s.
The horse streptococci P50 the gene sequence entered the BLAST service net industry that the NCBI provide first, handle stuffs with the form and list of the net industry up, the choice correspond of the parameter hand over to the data server to go forward to act like the source index(the homology Search).Many living creature information centers all have the BLAST server of the specialized movement.Here applied http:www. ncbi.nlm.nih.gov?b last?(Circulate BLASTR2.0, the United States, the maintenance GenBank)
Then the result detection of the basis BLAST index(Search) and the protein of the horse streptococci P50 gene sequence expression together the source is the tallest of 3 kinds of protein one by one in order is 123
The secondly applied DNASTAR software translates the horse streptococci P50 gene sequence into the amino acids sequence, the result manifestation P50 gene sequence translates 20 amino acidses totally.
Will and the horse streptococci P50 amino acids sequence together source the high sequence inputs to the tool software respectively, carrying on evolving a tree(the Phylogenetic Tree) to draw.
Hand over the horse streptococci P50 amino acidses(the Amino Acids) sequence(Sequence) to the professional website in, can immediately predict the second class structure of that amino acids sequence.Then make use of a software analysis P50 gene protein physics and chemistry property.
The Darwinian Theory of Evolution(the Evolutionary theory) gave comparison the gene set to learn to provide the theories basis.The relative relation(kinship) is more near, its gene sequence is a source(homology) together more high.Two sequences together the source is more high, may express the function of the outcome(the Expression Product) very much so more alike.Through the sorting to the result.Analytical, according to discover the horse streptococci P50 genes express of may be the fat egg white(the Substrate binding Lipoprotein) that a kind of bottom thing combine, participate the metals transport system(the Transport System) to constitute directly, the kind's transport system has in the germ from process acquire nourishment inside the host(HOST) body to close an important function.This kind of egg white is the fat egg white(the Substrate binding Lipoprotein) that a conveyance,such as the bottom thing of the metals ions, such as iron,manganese and zinc...etc., combine, we can call it as the streptococci metals to combine the fat egg white.(the Metal binding lipoproteins, MBLS)This kind of egg white is a kind of poisonous dint factor(the virulent factor) of the horse streptococci(the Streptococcus equi) is a germ with the result that the foundation of the disease to the horse streptococci physiology bio-chemical characteristic and pathogenic have very important influence and the meaning.
回答者：6392541196 - 同进士出身 六级 3-9 20:52
The horse streptococci(Streptococcus equi) belongs to an orchid surname the Cs of the germ a streptococci for cent and include the horse streptococci Ma3 Ya3 's kind(Streptococcus. equi subsp. Equi), the horse streptococci monster epidemic disease second kind(S. equi subsp. Zooepidemicus)with the horse Lian4 Qiu2 Jun4 Lei4 Ma3 Ya3 's kind(S. equi subsp. equisi milis).That germ can pass external injury, surgical operation, or cure etc. the path infect various animals and cause diseases, such as septicemia Sepsis, meningitis Encephalitis and mastitis(Mastitis)...etc..It particular gene expression the outcome be pathogenic(Pathogenicity) to germ to have special meaning.
Study gene, be in order to understand its function and expression and adjust to control a way.The information of make use of the living creature learn(Bioinformatics) and can adjust to control to carry on an estimate and analyze to function and expression of gene, saved to go to a trivial experiment to investigate, for test a verification to provide an instruction direction.Function and sequence of gene are closely-related, the likeness which is a sequence exceed certain scope, they probably carry out same function and pass will don't know a function sequence and have already known the contrast of function sequence, if their likeness is higher and then can predict a correspond of sequence function.
The purpose of this topic research be is learn with living creature information Be the usage tool of the theories foundation software with according to WEB of on-line service to some a have never known a horse streptococci the gene carries on a series of analysis and the result integrate and thus predict that this gene expresses the function of outcome.
The gene sequence of the horse streptococci P50 length is a 100 BPs and the whole gene has 1 to open all of the reading frame(ORF)s to grow a 90 BPs and code 100 amino acids remnants Ji.
The gene sequence of the horse streptococci P50 got into the BLAST service net industry that the NCBI provide first, once handle stuffs with the form and list on the net industry up, the choice correspond of the parameter hand over a data server to go forward to act like a source an index(homology Search).The many living creature information center all has the BLAST server of specialized movement.Here applied http:www. ncbi.nlm.nih.gov?b last?(Circulate BLASTR2.0, the United States, support GenBank)
Then the protein of the search result detection of the basis BLAST and the gene sequence of the horse streptococci P50 expression together the source be the tallest of 3 kinds of proteins one by one in order is 123
The secondly applied DNASTAR software translates the gene sequence of the horse streptococci P50 into an amino acids sequence and the gene sequence of the result manifestation P50 totally translates 20 amino acidses.
Will with the amino acids sequence of the horse streptococci P50 together source the sequence of the Gao inputs tool software respectively and carry on evolving a draw of tree(Phylogenetic Tree).
Hand over the amino acidses(Amino Acids) sequence(Sequence) of the horse streptococci P50 to the professional website in, then predict the second class structure of that amino acids sequence.Then make use of the physics and chemistry property of the gene protein of the software analysis P50.
The Darwinian Theory of Evolution(Evolutionary theory) give comparison gene the set learn to provide a theories basis.The relative relation(kinship) is more near, its gene sequence together source(homology) more high.Two sequences together the source be more high, so and very may express the function of outcome(Expression Product) more alike.The process i
这种最基本的东西没必要求论文啊，自己随便写写就好了，用个DNAMAN，随便挑个基因，分分钟搞出来。再者没人会拿这种东西单独去发一篇论文吧？这点东西根本不够资格，只够在某篇论文里的两句话的分量。
《中国科学 信息科学》(中文版)和《SCIENCE CHINA Information Sciences》(英文版)主要报道计算机科学与技术、控制科学与控制工程、通信与信息系统、电子科学与技术、生物信息学等领域基础研究和应用研究方面具有重要意义和创新性的最新成果. 以刊登论文为主, 同时适量刊登快讯、评述文章. 本刊努力为国内外专家提供严格、公正和快捷的评审, 是国内外专家和工程师了解中国信息科学发展的重要窗口之一. 中、英文版是相对独立的两个刊物.
ijb的意思是生物信息学的国际性专业期刊。
ijb是International Journal of Bioinformatics的英文缩写，意思是生物信息学的国际性专业期刊。生物信息学的国际性专业期刊主要刊载生物信息及相关领域的研究进展、综述、研究论文、研究简报、技术与方法、专题评论等学术文章。
生物信息学的国际性专业期刊登载的研究论文应是没有在国内外公开出版的刊物上发表过的原始研究工作报告；及时反映生物信息领域的发展热点和最新进展；本刊还刊登有关生物信息技术国内外研究开发动态、简讯、产业政策与产业发展动态、学术活动与展会通知、书评、短评、启事等文章。
生物信息学简介：
生物信息学(Bioinformatics)是研究生物信息的采集、处理、存储、传播，分析和解释等各方面的学科，也是随着生命科学和计算机科学的迅猛发展，生命科学和计算机科学相结合形成的一门新学科。它通过综合利用生物学，计算机科学和信息技术而揭示大量而复杂的生物数据所赋有的生物学奥秘。
生物信息学是在生命科学的研究中，以计算机为工具对生物信息进行储存、检索和分析的科学。它是当今生命科学和自然科学的重大前沿领域之一，同时也将是21世纪自然科学的核心领域之一。其研究重点主要体现在基因组学和蛋白质组学两方面，具体说就是从核酸和蛋白质序列出发，分析序列中表达的结构功能的生物信息。
以上内容参考 百度百科-生物信息学
