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论文1. Jun Yi, Xiaoli Ye, Dezhen Wang, Kai He, Yong Yang, Xujing Liu, Xuegang Li. Safety evaluation of main alkaloids from Rhizoma Coptidis. Journal of Ethnopharmacology, 2013.145:303-310。2. Jinfeng Wu, Xiaoli Ye, Xuelong Cui, Xuegang Li, Lifeng Zheng and Zhu Chen. Reducing the inhibitory effect of cigarette smoke on oral peroxidase activity by addition of berberine in cigarette filter. Toxicology and Industrial Health. 2013. 29(4):317.3. Kai He, Xiaoli Ye∗, Xuegang Li∗∗, Hongying Chen, Lujiang Yuan, Yafei Deng, Xin Chen, Xiaoduo Li。Separation of two constituents from purple sweet potato by combination of silica gel column and high-speed counter-current chromatography。Journal of Chromatography B。2012,881-882:49~54.4. Cytotoxicity and antihyperglycemic effect of minor constituents from Rhizoma Coptis in HepG2 cells.Hong-Ying Chen, Xiao-Li Ye, Xue-Long Cui, Kai He, Ya-Nan Jin, Zhu Chen, Xue-Gang Li. Fitoterapia。 2012, Vol 83, Iss 1, pp 67-73.5. Yafei Denga, Kai He, Xiaoli Ye, Xin Chen, Jing Huang, Xuegang Li, Lujiang Yuan*, Yalan Jin,Qing Jin, Panpan Li. Saponin rich fractions from Polygonatum odoratum (Mill.) Druce with more potential hypoglycemic effects. Journal of Ethnopharmacology,141 (2012) 228– 233。6. Chen Zhu, Ye Xiaoli, Yi jun, Chen Xin, Li Xuegang. Synthesis of 9-O-glycosyl-berberine derivatives and bioavailability evaluation. Med Chem Res, 2012.V21(8):1641~1646.7. Baoshun Zhang,Tingting Chen,Zhu Chen,Mingxue Wang,Dengyu Zheng,Jinfeng Wua,Xiaofei Jiang, Xuegang Li。Synthesis and anti-hyperglycemic activity of hesperidin derivatives。Bioorganic & Medicinal Chemistry Letters。2012,22:7194-7197。8. Kai He, Xuegang Li, Xiaoli Ye, Lujiang Yuan, Xiaoduo Li, Xin Chen, Yafei Deng. A mitochondria-based method for the determination of antioxidant activities using 2’,7’‐dichlorofluorescin diacetate oxidation. Food Research International 48 (2012) 454–461.9 Xiaoli Ye,Kai He,Xiaokang Zhu,Baoshun Zhang ,Xin Chen,Jun Yi,Xuegang Li. Synthesis and antihyperlipidemic efficiency of berberine-based HMG-CoA Reductase Inhibitorreductase inhibitor。Med Chem Res, (2012) 21:1353–1362.10. Jinfeng Tian, Xiaoli Ye, Xuegang Li 。Preparative isolation and purification of harpagoside and angroside C from the root of Scrophularia ningpoensis Hemsley by high-speed counter-current chromatography。J. Sep. Sci. 2012, 35, 2659–2664。11. Teng-Wen Ma, Xiao-Li Ye, Xue-Gang Li, Bao-Shun Zhang, Xiao-Fei Jiang and Zu Chen. Synthesis and Antimicrobial Activity of 8-Alkylpalmatine Derivatives.Letters in Drug Design & Discovery, 2011, 8,464~468.12. Yang yong, Ye xiao-li, Zhang Bao-shun, Li Xue-gang. Effect of 8-alkyberberine homologues on erythrocyte membrane. Indian Journal of experimemtal biology. 2011. 49(5):319~323.132. Xiaoli Ye, Xin Chen, Kai He, Jun Yi, Xuegang Li, Ping Li and Xiaohong Wang. Study of antihyperlipidemic effect on rabbits of 8-alkylberberine derivatives. Journal of Medicinal Plants Research. 2011, 5(8), 1390-1394.14. Baoshun Zhang, Xiaoli Ye, Zhu Chen, Xiaofei Jiang, Lujiang Yuan, Jun Yi, Xuegang Li. Synthesis and antimicrobial activity of 7-alkoxyhesperetin derivatives. Med Chem Res, (2011) 20:1200–120515. Xiao-fei Jiang, xiao-li Ye, Baoshun Zhang and Xue-gang Li. Synthesis and Antimicrobial Activity of 8-Alkyl Coptisine Derivatives. Asian Journal of Chemistry. 2011, 23(9): 3849~385216. Kai He,Xuegang Li,Xin Chen,Xiaoli Ye,Jing Huang,Yanan Jin,Panpan Li,Yafei Deng,Qing Jin,Qing Shi,Hejing Shu 。Evaluation on Antidiabetic Potential of Selected traditional Chinese Medicines in STZ-induced Diabetic Rats。Journal of Ethnopharmacology. 137:1135~1142。2011.17. Xiao-li Ye,Wen-wen Huang,Zhu chen,Xue-gang Li,Ping Li,Ping Lan,Liang Wang,Ying Gao,Zhong-qi Zhao,Xin Chen。Synergetic Effect and Structure- Activity Relationship of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Inhibitors from Crataegus pinnatifida Bge. J. Agric. Food Chem. 2010. 58 (5):3132–3138.18. H.-P. Wei, X.-L. Ye, Z. Chen, Y.-J. Zhong, P.-M. Li, S.-C. Pu, X.-G. Li. Synthesis and pharmacokinetic evaluation of novel N-acyl-cordycepinderivatives with a normal alkyl chain. European Journal of Medicinal Chemistry, 2009, 44:665~669。19. Li-Jun Wang, Xiao-Li Ye, Zhu Chen, Xue-Gang Li, Qing-Lei Sun, Bao-Shun Zhang, Xiao-Gang Cao, Gang Yu, Xiao-Hua Niu. Synthesis and antimicrobial activity of 3-octyloxy -8-alkyljatrorrhizine derivatives. Journal of Asian Natural Products Research, 2009, 11(4):365~370。20. G.-J. He a, X.-L. Ye, X. Moua, Z. Chen, X.-G. Li a。 Synthesis and antinociceptive activity of capsinoid derivatives。European Journal of Medicinal Chemistry, 2009。44:3345~3349。21. Zhu Chen, Xue-Gang Li, Yong-Sheng Xie and Xiao-Li Ye. 9-O-Butyl-berberrubine bromide. Acta Crystallographica Section E, 2009, E65,o1370。22. Xiaoli Yea, Li Xua, Xuegang Li b,∗, Zhu Chenb, Baoshun Zhangb, Lujiang Yuanb, Xing Chenb, Huajin Zhanga, Wen Changa, Shengliang Suna。 Antibacterial mechanism of houttuyfonate homologues against Bacillus subtilis。Colloids and Surfaces A: Physicochemical and Engineering Aspects。350 (2009):130–135。23. WANG Li-Jun,YE Xiao-Li,LI Xue-Gang*,YU Gang, Cao Xiao-Gang,liang yan-tin,zhang hua-san。Synthesis and Antimicrobial Activity of 3-alkoxy-jatrorrhizine Derivatives。Planta Medica, 2008, 74:290~292。24. Ye Xiaoli, Li Xuegang, Lujiang Yuan, Linhu Ge, Shaobo Zhou. Interaction between houttuyfonate homologues with the cell membrane of Gram-positive and Gram-negative Bacteria. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2007,301:412~418.25. Yuan Luijiang,Ye Xiaoli, Li Xuegang. Effect of octadecanoyl acetal sodium sulfite series with different numbers of double bond on their immunologic and surface activities. Journal of Asian Natural Products Research, 2007, 9(1):49~58.26. Yang Yong, Ye Xiaoli, Li Xuegang, Zhen Jing, Zhang Baoshun, Yuan Lujiang. Studies on Synthesis and Antimicrobial Activity of 8-alkyl Berberine Derivatives with Long Aliphatic Chain. Planta Medica, 2007, 73:602~604.27. Ye Xiaoli, Li Xuegang . Interaction between houttuyfonate homologues and erythrocyte plasma membrane of rabbit in vitro. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2006,279:218~224.28. Ye Xiaoli, Li Xuegang,Yuan lui jiang, he hong mei. Relationship between the antibacterial and immunologic activities of Houttuyfonate homologues and their surface activities. Journal of Asian Natural Products Research, 2006, 8(4):327~33429. Ye Xiaoli, Li Xuegang. Effect of the Surface Activity on the Antibacterial Activity of Octadecanoyl Acetal Sodium Sulfite Series. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2005, 268:85~89。30. Wang B.J., Zhang Z.G, Li X.G, Wang Y.J., He C.Y., Zhang J.S., Chen S,Y., “Cloning and analysis of a disease resistance gene homolog from soybean”, Acta Botanica Sinica, 2003,45(7):864~870.31. Ye Xiaoli, Li Xuegang, Shu Changbing, Chen Shihong, Wang Qiang. (2000) The effects of surfactants on the activity of invertase and SOD of soybean leaf in vitro and in vivo. Colloid and Surface, 175:249~255.32. Ye Xiaoli, Li Xuegang, Chen Shihong, Wang Qiang. (2000) Effects of SFE on the activity of invertase of soybean leaf in vitro and vivo. Acta phytophysiologia Sinica, 26(5):446~452.33. Li Xue-gang,Zhang Guang-xian, Zhang Min-xiao, Wu Guang-quan. (1996) The surface activity and solubilization of anionic-cationic surfactant. Colloid and Surface, 111:161~166.34. Li xue-gang,liu Fa-min. (1995) Phase separation of the aqueous solution and the surface activity of oxyethylenated cationic anionic surfactants. Colloid and Surface, 96:113。35. Zhao Guo-xi,Li Xue-gang, (1991) Solubilization of n-octanol and n-octane by mixed aqueous solution of cationic-anionic surfactants. J.Colloid & Interf. Sci, 144:185.36. 陈红英,李学刚,叶小利,晋亚楠,黄 静,吴金凤。黄连中胆碱的分离及其对小檗碱在HepG2细胞中糖代谢作用的影响.中国中药杂志,2012,37(12):26~31。37. 丁阳平; 叶小利; 周洁; 罗赛; 练梦菲; 李学刚. 小檗碱衍生物合成及生理活性研究进展。有机化学,2012.32:667~685。38. 金 清,白晓华,邓亚飞,李学刚,袁吕江。木香降血糖有效部位及有效成分研究。中草药,2012,43(7):1371.39. 李琼,叶小利,曾红,陈新,李学刚。天花粉凝集素的提取工艺及降糖活性研究。中草药,2012,35(3):475。40.贺凯,李学刚, 陈红英, 叶小利, 邓亚飞, 陈新, 孙胜亮. 薄层色谱-荧光法联用测定黄连生物碱分配系数. 分析化学,2011,39(4):572~575.41. 张保顺,叶小利,陈竹,姚波,谭平,李学刚。有特色已完成的甲基橙皮素-7-烷基醚同系物的合成及其抗炎作用。药学学报,2011, 46 (7):811~817.42. 蒋小飞,李学刚,汤琳,叶小利。8-烷基黄连碱同系物的合成及体外降糖作用。中草药。2011,42(4):640~643。43. 杨红军,孙凤青,李朝荣,王豪举,冯昌荣,李学刚,张建明。利用中药防治长毛兔热应急。中国兽医杂志。2011,47(5):75。44. 王亮,叶小利,李学刚,陈竹,陈晓丹,高英,赵中启,黄文文,陈新,易骏。黄连生物碱在大鼠体内的代谢转化及分布.中国中药杂志,2010, 35(15):2017~2020.45. 黄文文,叶小利,李学刚,蓝萍,王亮,高英,朱家颖,李平,冯平.山楂中抑制HMG-CoA还原酶的活性成分及其协同效应的研究.中国中药杂志,2010, 35(18):2428~2431.46. 朱小康;叶小利;袁吕江;朱家颖;丁阳平;李学刚. 微波辐射下6-烷氧基大黄酸的合成及抑菌活性研究. 有机化学,2010,30(9):1335~134147. 丁阳平,叶小利,朱家颖,朱小康,李学刚。8-烷基—13-溴代盐酸小檗碱合成及对人体肝癌细胞株增殖的影响。中草药,2010,41(11):1765~1770。48. 李萍,王小红,冯平,李学刚,何臣。平抑舒治疗 2 型糖尿病阴虚热盛型 30 例临床观察。新中医,2010,42(9):31~33。49. 于刚, 曹晓钢, 叶小利, 李学刚, 陈竹, 袁吕江, 王立军. HPLC测定3-羟基-3-甲基戊二酸单酰辅酶A还原酶抑制剂的活性. 分析化学,2009,V37(1):87~90。50. 许理,李学刚,陈竹,张飞,叶小利.HPLC测定鱼腥草素对鸭肝脂肪酸合成酶活性影响.分析化学,2009, 37(5):729~732。51. 李亚梅,叶小利,李雪梅,褚浩锋,胡莎莎,刘国印,朱炎,李学刚. 助剂对小鼠吸收黄连总生物碱的影响及药代动力学的研究. 中国中药杂志(China Journal of Chinese Materia Medica), 2009, 34(3):344~348.52.韦会平,叶小利,张华英,李学刚,钟英俊。用蛹虫草固体发酵法高效生产虫草素的研究。中国中药杂志。2008,33(19):2159~2162。53. 李逐波, 叶小利, 袁吕江, 李学刚, 高效液相色谱法测定动物组织中鱼腥草素同系物含量。分析化学,2007,35(2):297~300。54. 杨 勇, 叶小利, 郑 静, 张保顺, 李学刚.8-烷基盐酸小檗碱的合成及活性研究. 有机化学, 2007,27(11):1438~1440。55. 张兰辉,李学刚. (1993) 盐酸胍、脲对溶液中疏水链疏水能的影响. 化学学报, 51(8):869~873.56 李学刚, 邹承鲁. (1993) 盐酸己烷基双胍对肌酸激酶的活力及构橡的影响. 生物物理学报, 9(1):1~5. 专利技术1、“综合利用胱氨酸母液废水生产单一氨基酸及消除污染的方法”。专利号:ZL01132740.5。2、 黄连花或/和叶茶。发明人:李学刚、袁吕江、叶小利。中国技术发明专利,专利号:ZL 2005 1 0020601.X。3、 黄连农药增效剂。发明人:李学刚;吴光权;叶小利;何红梅。中国技术发明专利,专利号:ZL 2005 1 00206005。4、 8-辛基小檗碱盐酸盐、合成方法及应用。发明人:叶小利;李学刚。中国技术发明专利,专利号:ZL200610095288.0。5、长链烷基小檗碱盐衍生物、合成方法及应用。发明人:叶小利;李学刚。中国技术发明专利,专利号:ZL200710078505.X。6、4-烷氧基-香豆素脂肪酸酯、合成方法及应用。发明人: 叶小利;李学刚;袁吕江。中国技术发明专利,专利号:200810070223X。7、8-烷基加兰他敏盐及其制备方法和应用。发明人: 叶小利;李学刚。中国技术发明专利,专利号:ZL200910103606.7。8、黄连碱的提取方法。发明人:李学刚;叶小利;袁吕江。中国技术发明专利,专利号:ZL2009101916207。9、一种黄连总生物碱提取工艺技术。发明人:叶小利;李学刚;袁吕江。中国技术发明专利,专利号:ZL200810069671.8。10、一种预防和治疗兔子热应急的复方中草药制剂。发明人:李学刚;冯昌荣。中国技术发明专利,专利号:ZL200910103145.3。11、一种预防和治疗猪冬痢疾的中草药复方制剂。发明人:李学刚;冯昌荣。中国技术发明专利,专利号:ZL200910103144.9。12、降血压药物3-烷氧基—芒果苷、合成及应用。发明人:叶小利,李学刚。中国技术发明专利,专利号:ZL200910104184.5。13、一种以黄连须根为原料联产黄连生物碱提取方法。发明人:李学刚;叶小利。中国技术发明专利,专利号:ZL200810233362.X。14、一种治疗糖尿病的中药复方制剂。发明人:谢正杰。中国技术发明专利,专利号:200910103527.6。15、一种从黄连种提取阿魏酸和绿原酸等酸性成分的方法。发明人:李学刚;叶小利。中国技术发明专利,专利号:ZL201010514629.X。16、一种治疗湿热困脾型糖尿病的黄连复方制剂。发明人: 李学刚;叶小利。中国技术发明专利,专利号:ZL201010547697.6。17、N-烷酰基虫草素在制备治疗肿瘤疾病的药物中的应用。发明人:叶小利;李学刚。中国技术发明专利,专利号:ZL200910104006.2。18、一种具有降糖作用的黄连生物碱与阿魏酸复合物。发明人:李学刚;叶小利。中国技术发明专利,专利号:ZL201010514620.9。19、一种多功能复方黄连中草药牙膏。发明人:李琼、叶小利、李学刚、袁吕江。中国技术发明专利,专利号:201110085036.0。20、一种预防和治疗糖尿病肾病的中药复方制剂。发明人:李学刚、易骏、叶小利。中国技术发明专利,专利号:201110258401.3。21、3-烷氧基-6-羧基大黄酸或其可药用盐及其制备方法和应用。发明人:李学刚;朱小康。中国技术发明专利,专利号:200910104466.5。22、提高壳斗科植物叶提取物抗菌活性的方法。发明人:袁吕江,李学刚,金清,邓亚飞。中国技术发明专利,专利号:201110031074.8。23、用于治疗糖尿病的中药组合物及其制剂。发明人:李学刚、叶小利。中国技术发明专利,申请号:201110444253.4。24、葛根黄酮提取物的制备方法及其产品。发明人:李学刚、袁吕江、叶小利。中国技术发明专利,专利号:201110458717.7。25、具有减肥美容作用的玉葛粉及其制备方法。发明人:李学刚、叶小利。中国技术发明专利,专利号:201210035015.2。26、9-O-糖苷-小檗碱盐及其制备方法和应用。发明人:袁吕江,叶小利,李学刚。中国技术发明专利,专利号:201010589543.3。
1. 响应曲面法优化黄参酸奶生产工艺.食品科学(CSCD核心库期刊),2011,32(12):39-44(第一作者)2. 荷叶离褶伞菌丝体深层发酵及胞内外多糖含量的变化.中国酿造(CSCD核心库期刊),2011,230(5):56-59(第一作者)3. 荷叶离褶伞子实体、菌丝体及发酵液蛋白质营养价值评价伤.菌物学报(CSCD核心库期刊),2010,29(4):603-607(第三作者)4. 葡萄表面所得酵母的筛选及其鉴定.食品工业科技(CSCD核心库期刊),2010,31(6):182-184(第二作者)5. 人参果酸奶制作工艺的研究.中国酿造(CSCD核心库期刊),2009,212(11):167-169(第一作者)6.肉苁蓉多糖提取工艺及抑菌作用的研究.安徽农业科学(CSCD核心库期刊),2009,37(32):15855-15856,15878(第一作者)7.极大螺旋藻酸奶加工工艺的研究.中国酿造(CSCD核心库期刊),2009,213(12):155-158(第一作者)8.荷叶离褶伞子实体发酵液营养成分分析.食品科学(CSCD核心库期刊),2009,31(6):155-157(第三作者)9.酿酒酵母菌的紫外诱变及其突变株的性能测定.中国酿造(CSCD核心库期刊),2009,211(10):66-68(第二作者)10.荷叶离褶伞多糖的提取工艺及其抑菌作用的研究.中国食品工业,2009,(12):51-53(第一作者)11.曼陀罗种子生物碱提取物抑菌活性的研究. 甘肃农业,2009,(5):90--92(第一作者)12.”Ni2+“对大蒜根尖细胞有丝分裂的影响. 作物杂志(CSCD核心库期刊),2008,(1):37-40(第一作者)13.黄花蒿不同溶剂提取液的抑菌作用研究,中国野生植物资源,2008,(3):45-48(第一作者)通讯作者14.镉胁迫对红果龙葵幼苗生理生化的影响. 沈阳农业大学学报,2008,(2):(第三作者)15.”Cd2+“对龙葵根尖细胞有丝分裂的影响. 河西学院学报,2007,(5):48-50(第一作者)16.工业废水对黄瓜幼苗生长及叶片抗氧化系统的影响.干旱地区农业研究(CSCD核心库期刊),2006,24(4):76-80(第三作者)
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