研究方向: 对中药有效成份分子结构进行系统的化学修饰;药物合成与质量研究;药物合成工艺优化等。 工作成效: 发表学术论文40余篇,申请发明专利(包括PCT)近30项,曾主持过国家新药创制重大专项、国家科技计划、省、市重大专项等科技项目20项。指导本科毕业生多人获优秀毕业论文,参与指导的第七届“挑战杯”中国大学生创业计划竟赛,荣获全国“金奖”。被暨南大学评为2010年度科研先进工作者,被国际学院评为2012年度最佳全英授课教师。 教学工作主讲本科专业必修课:全英课程 Medicinal Chemistry 和Experimental MedicinalChemistry 参与本科专业选修课:药学英语主讲研究生课程:实验室安全知识,药品生产质量管理,化学制药工艺学 在研项目1、国家“重大新药创制”科技重大专项 2009ZX09102-010具有降糖和保护胰岛双重功能的糖尿病I类新药AL-1的临床前研究(主持)2、国家“重大新药创制”科技重大专项2009ZX091030-031 抗脑中风侯选一类新药TBN的开发研究(参加)3、广州对外科技合作专项,2011-2013年,项目编号11S52070024 治疗帕金森病新型药物的研究开发(主持)4、广东省教育厅科研项目,2012-2013年,新型抗心肌缺血药ADTM的研究开发(主持)5、第十三批教学改革研究项目,2012年,药学应用型人才培养毕业设计模式的探索与实践(主持) 代表论文:1. Zhongli Wang, Pei Yu,* . Design, synthesis and antibacterial activity of novel andrographolide derivatives. Bioorganic & Medicinal . Hongli Sun, Lipeng Xu, Pei Yu and preliminary evaluation of neuroprotection of celastrol analogues in PC12 cells. Bioorg & Med. Chem. Lett. 2010,20(13),. Xiaoyu Lu, Jie Jiang, Xiaojian Jiang, Sainan Wan, Wenjing Yang, Pei Yu. Synthesis and Biological Evaluations of Novel Apocynin Analogues. Eur. J. Med. Chem. 2011, 46(7), . Zai-Jun Zhang, Sha Li, Jie Jiang, Pei Yu, Jing Liang, and Yu-Qiang Wang. Preventive effects of Flos Perariae (Gehua) water extract and its active ingredient puerarin in rodent alcoholism models Chinese Medicine. 2010, 5, 36. 5. Zhang Gaoxiao, Cui Qingbin, Yu Pei, Wang Yuqiang*, Synthesis and preliminary evaluation of anti-HIV agent AZT prodrug. Acta Pharmaceutica Sinica, 2011. 46(8), . Hui YAO, Sha LI, Pei YU, Xiaodan TANG, Yuqiang WANG Characteristics of Andrographolide and its Analogue AL-1 with GSH . Molecules 2012, 17, 728-7397. Zeqing Li, Zhibin Liang, Yuqiang Wang , Pei Yu* Microwave-assisted, Ir catalyzed aromatic C-H borylation. Research on Chemical Intermediates 2012. 8. Sun, Y.; Zhang, G.; Zhang, Z.; Yu, P.; Zhong, H.; Du, J.; Wang, Y. Novel multi-functional nitrones for treatment of ischemic stroke,Bioorg. Med. Chem. 2012, 20, 3939–. Yonghong Chen, Mingjuan Zhang, Qingbin Cui, Luchen Shan, Pei Yu, Gaoxiao Zhang, Dingyuan Wang, Zengchao Zhao, Qian Xu, Benhong Xu, Yuqiang Wang. Synthesis and Cardioprotective Effects of Novel Danshensu Analogues. Eur J Med Chem. 2012. (In press) 10. Pei Yu, Longfei Xia, Jing Zhao, Gaoxiao Zhang, Zaijun Zhang, Wei Li, Junlan Ren, Qian Cheng,Yuqiang Wang* Synthesis and Preliminary Anticancer Evaluation of 10-Hydroxycamptothecin Analogs. . Bull. 2012, 35(8), 1-5. 11. Yewei Sun, Pei Yu, . Therapeutic Effects of Tetramethyl- pyrazine Nitrone in Rat Ischemic Stroke Models. Journal of Neuroscience Research2012, 90, 1662–. GuoZhen Cui, Luchen Shan, MingWai Hung, Siwan Lei, InLeng Choi, ZaiJun Zhang,Pei Yu, PuiMan Hoi, Yuqiang Wang, Simon MingYuen Lee. A novel Danshensu derivative confers cardioprotection via the PI3K/Akt and Nrf2 pathways. Int J Cardiol. 2012.