1.如果能补充的话,尽量补,除非因为样本的原因或是毕业在即!2.说明本次研究的主要目的:如主要是测血清水平的而不是测蛋白水平或基因水平的,证实本实验足以得出相应结论。(但谦虚是必要的,先感谢一下reviewer的意见,然后We understand that **(要补的实验)may better reveal the ....... However, in the present study, we mainly focused on......, and we think that ***(你已经做的实验) may not be optimal, but should be sufficient to draw a conclusion that ......3.以前文献已经做过,直接引用。并且说明本次实验是从另一个层面来证实他们的结论。4. 自己曾经遇到的一个问题以及自己的回答,供大家参考:Question: Of the patients who had ** how many had biopsies? If they did and were**+ how many revealed characteristics of ** associated vasculitis? Did any biopsies in patients who were not ** + reveal characteristics of ** associated vasculitis?Re: This is one limitation of this study, in consideration of injury of biopsies and our central aim is to study the relationship between serum ** and **, so we have not performed renal biopsies. We understand that renal biopsies can better reveal the correlation between ** and **, it will be considered in our further study.