1980-1986年 上海医科大学医学士
1986-1991年 美国史丹福大学肿瘤生物学博士
1991-1994年 哈佛大学生物化学和分子生物学系博士后
参考资料
1994年起 任华盛顿大学儿科系和分子生物与药理学系助理教授分子遗传学、分子细胞生物、发育生物学等学科博士生导师
1998年起 兼上海医科大学教授
2001年起 参与中国科学院上海生命科学研究院分子生物学研究生课程教学,后升副教授并获终身教职
2003-2005 美国Vanderbilt大学,教授
2005-2008 美国西北大学医学院,Lurie 癌症中心,Charles Luis Mix 教授
2008-至今 中国科学院生物物理研究所,高级顾问研究员
吴瑛研究员所在课题组主要研究参与神经发育和神经推行性病变的基因调控的分子机制
1)RNA调控
2)细胞迁移的分子机制
为Science、Nature、Cell、MCB、PNAS等15个杂志审稿,为美国国立健康研究院、老年痴呆基金会、加拿大医学研究委员会、义大利Telethon基金会等评审基金。在哈佛大学参与生物化学教学、在华盛顿大学参与核酸与蛋白质、细胞生物学博士生课程教学, 在英国剑桥、美国哈佛大学、宾州大学、布朗大学等做过学术报告 。
现任美国西北大学讲座教授,清华大学长江讲座教授,中国科学院生物物理研究所研究员。吴瑛以研究RNA剪接的分子生物学著名。曾获中国国家自然科学基金委员会"国家杰出青年基金"B类 。
论文发表于Cell、Nature、Science、MCB、J.Neuroscience,、JBC。曾获美国白血病学会连续十二年资助(从博士后、特别研究员到学者奖)
Göhrig A, Detjen KM, Hilfenhaus G, Körner J, Arsenic R, Welzel M, Schmuck R, Bahra M, Wu JY, Wiedenmann B, Fischer C(2014). The Axon Guidance Factor Slit2 inhibits Pancreatic Cancer Metastasis and Cell Movement along Neurites. Cancer Res .74(5):1529-40
Li Y, Yang M, Huang Z, Chen X, Maloney M, Zhu L, Liu J, Yang Y, Du S, Jiang X,Wu JY.(2014) AxonQuant: a microfluidic chamber culture-coupled algorithm that allows high-throughput quantification of axonal damage. NeuroSignalsFeb 28.
RNA and Cancer. Wu JY (ed.) ISBN 978-3-642-316586; Library of Congress Control Number 2012946188 (Springer, 2013) [book summary]
POST-TRANSCRIPTIONAL GENE REGULATION-RNA PROCESSING IN EUKARYOTES. Wu JY (ed.) ISBN 978-3527322022 (Wiley-Blackwell, 2013) [book summary]
Bigio EH,Wu JY, Deng HX, Bit-Ivan EN, Mao Q, Ganti R, Peterson M, Siddique N, Geula C, Siddique T, Mesulam M.(2013) Inclusions in frontotemporal lobar degeneration with TDP-43 proteinopathy (FTLD-TDP) and amyotrophic lateral sclerosis (ALS), but not FTLD with FUS proteinopathy (FTLD-FUS), have properties of amyloid. Acta Neuropathol . 125(3):463-5.
Xu M, Zhu L, Liu J, Yang Y,Wu JY, Wang C(2013) Characterization ofβ-domains in C-terminal fragments of TDP-43 by scanning tunneling microscopy. J Struct Biol. 181(1):11-6.
Chen Q, Sun X, Zhou XH, Liu JH,Wu J, Zhang Y, Wang JH(2013) N-terminal horseshoe conformation of DCC is functionally required for axon guidance and might be shared by other neural receptors.J Cell Sci. 126:186-95.
Zhu K, Chen XP, Liu JH, Ye Hh, Zhu L,Wu JY(2013) AMPK interacts with DSCAM and plays an important role in Netrin-1 induced neurite outgrowth. Protein Cell 4 (2): 155–161.
Chen Y, Yang M, Deng J, Chen X, Ye Y, Zhu L, Liu J, Ye H, Shen Y, Li Y, Rao EJ, Fushimi K, Zhou X, Bigio EH, Mesulam M,Wu JY.(2011) Expression of human FUS protein in Drosophila leads to progressive neurodegeneration. Protein Cell 2(6):477–486.
Ray P, Kar A, Fushimi K, Havlioglu N, Chen X,Wu JY(2011) PSF Suppresses Tau Exon 10 Inclusion by Interacting with a Stem-Loop Structure Downstream of Exon 10.J Mol Neurosci .45(3):453-66.
Xu Y, Ye H, Shen Y, Xu Q, Zhu L, Liu J, Wu JY.(2011) Dscam mutation leads to hydrocephalus and decreased motor function.Protein Cell.2(8):647-55.
Yu B, Fey P, Kestin-Pilcher KE, Fedorov A, Prakash A, Chisholm RL, Wu JY.(2011) Spliceosomal genes in the D. discoideum genome: a parison with those in H. sapiens, D. melanogaster, A. thaliana and S. cerevisiae.Protein Cell.2(5):395-409.
Guo W, Chen Y, Zhou X, Kar A, Ray P, Chen X, Rao EJ, Yang M, Ye H, Zhu L, Liu J, Xu M, Yang Y, Wang C, Zhang D, Bigio EH, Mesulam M, Shen Y, Xu Q, Fushimi K, Wu JY.(2011) An ALS-associated mutation affecting TDP-43 enhances protein aggregation, fibril formation and neurotoxicity.Nat Struct Mol Biol.18(7):822-30.
Kar A, Fushimi K, Zhou X, Ray P, Shi C, Chen X, Liu Z, Chen S, Wu JY.(2011) RNA Helicase p68 (DDX5) regulates tau exon 10 splicing by modulating a stem-loop structure at the 5' splice site.Mol Cell Biol.31(9):1812-21.
Fushimi K, Long C, Jayaram N, Chen X, Li L, Wu JY.(2011) Expression of human FUS/TLS in yeast leads to protein aggregation and cytotoxicity, recapitulating key features of FUS proteinopathy.Protein Cell.2(2):141-9.
Dunaway CM, Hwang Y, Lindsley CW, Cook RS, Wu JY, Boothby M, Chen J, Brantley-Sieders DM.(2011) Cooperative signaling beeen Slit2 and Ephrin-A1 regulates a balance beeen angiogenesis and angiostasis.Mol Cell Biol.31(3):404-16.
Brantley-Sieders DM, Dunaway CM, Rao M, Short S, Hwang Y, Gao Y, Li D, Jiang A, Shyr Y, Wu JY, Chen J.(2011) Angiocrine Factors Modulate Tumor Proliferation and Motility through EphA2 Repression of Slit2 Tumor Suppressor Function in Endothelium.Cancer Res.71(3):976-987.
Gao X, Joselin AP, Wang L, Kar A, Ray P, Bateman A, Goate AM, Wu JY.(2010) Progranulin promotes neurite outgrowth and neuronal differentiation by regulating GSK-3β.Protein Cell.1(6):552-62.
Guo W, Li JT, Pan X, Wei L, Wu JY.(2010) Candidate Mycobacterium tuberculosis genes targeted by human microRNAs.Protein Cell.1(5):419-21.
Kaneko N, Marín O, Koike M, Hirota Y, Uchiyama Y, Wu JY, Lu Q, Tessier-Lavigne M, Alvarez-Buylla A, Okano H, Rubenstein JL, Sawamoto K.(2010) New neurons clear the path of astrocytic processes for their rapid migration in the *** brain.Neuron.67(2):213-23.
Yu J, Cao Q, Yu J, Wu L, Dallol A, Li J, Chen G, Grasso C, Cao X, Lonigro RJ, Varambally S, Mehra R, Palanisamy N, Wu JY, Latif F, Chinnaiyan AM.(2010) The neuronal repellent SLIT2 is a target for repression by EZH2 in prostate cancer.Oncogene.29(39):5370-80.
Ray P, Luo XY, Rao EJ, Basha A, Woodruff EA, Wu JY.(2010) The splicing factor Prp31 is essential for photoreceptor development in Drosophila.Protein Cell1(3):267-274.