小分子荧光探针投稿期刊

1、国家重大科学研究计划项目（973）：重大疾病相关的若干重要难检活性小分子细胞内纳米传感研究，No.2013CB933800, 2013-2017。2、国家自然科学基金重点项目：活细胞内分子事件过程示踪的荧光成像探针的探索性研究No.21035003, 2011 -2014。3、国家自然科学基金科学仪器基础研究专项：适用于单细胞内活性小分子物种检测的荧光分析仪No.21035003, 2013-2016。 唐波教授现已在J. Am. Chem. Soc., Angew. Chem. Int. Ed., Adv. Funct. Mater., Anal.Chem., Biomaterials, Lab Chip, Chem.Commun., Chem. Eur. J.等杂志发表SCI论文240余篇，影响因子大于5.0的论文有90余篇，引用5000余次。代表性论文有：1. Wei Zhang, Wei Liu, Ping Li*, Haibin Xiao, Hui Wang, and Bo Tang*. A Fluorescence Nanosensor for Glycoproteins with Activity Based on the Molecularly Imprinted Spatial Structure of the Target and Boronate Affinity. Angew. Chem. Int. Ed., 2014, 53, 12489-12493.2. Wen Zhang, Ping Li, Fan Yang, Xiufen Hu, Chuanzhi Sun, Wei Zhang, Dezhan Chen, and Bo Tang*. Dynamic and Reversible Fluorescence Imaging of Superoxide Anion Fluctuations in Live Cells and in Vivo. J. Am. Chem. Soc., 2013, 135, 14956-14959.3. Na Li, Chenyang Chang, Wei Pan, Bo Tang*. A Multicolor Nanoprobe for Detection and Imaging of Tumor-Related mRNAs in Living Cells. Angew. Chem. Int. Ed., 2012, 51, 7426-7430.4. Bo Tang*, Fabiao Yu, Ping Li, Lili Tong, Xia Duan, Ting Xie, and Xu Wang, A Near-Infrared Neutral pH Fluorescent Probe for Monitoring Minor pH Changes: Imaging in Living HepG2 and HL-7702 Cells. J. Am. Chem. Soc., 2009, 131, 3016-3023.5. Bo.Tang*, Yanlong Xing, Ping Li, Ning Zhang, Fabiao Yu, and Guiwen Yang , A Rhodamine-Based Fluorescent Probe Containing a Se-N Bond for Detecting Thiols and Its Application in Living Cells. J. Am. Chem. Soc., 2007, 129, 11666-11667.6. Yu-Bin Dong,* Peng Wang, Jian-Ping Ma, Xia-Xia Zhao, Bo Tang* and Ru-Qi Huang, Coordination Driven Nanosized Lanthanide ‘Molecular Lantern’ with Tunable Luminescent Properties. J. Am. Chem. Soc., 2007, 129, 4872-4873.7. Yu-Bin Dong,* You-Yun Jiang, Jie Li, Jian-Ping Ma, Feng-Ling Liu, Bo Tang,* Ru-Qi Huang, and Stuart R. Batten, Temperature-Controlled Synthesis of Metal-Oragnic Frameworks Based on Acyclic Crown Ether Bridging Tetradentate Ligand with Bidirectional Coordination Donors. J. Am. Chem. Soc., 2007, 129, 4520-4521.8. Yu-Bin Dong,* Qiang Zhang, Li-Li Liu, Jian-Ping Ma, Bo Tang* and Ru-Qi Huang, Cu(C24H22N4O3)CH2Cl2: A Breathing Discrete Metallamacrocycle Showing Selective Reversible Guest Adsorption with Retaining Single-Crystallinity. J. Am. Chem. Soc., 2007, 129, 1514-1515.9. Na Li, Zhengze Yu, Wei Pan, Yaoyao Han, Tingting Zhang, and Bo Tang*. A Near-Infrared Light-Triggered Nanocarrier with Reversible DNA Valves for Intracellular Controlled Release. Adv. Funct. Mater., 2013, 23, 2255-2262.10. Xu Wang, Juan Sun, Weihong Zhang, Xiaoxu Ma, Jianzheng Lv and Bo Tang*. A near-infrared ratiomateric fluorescent probe for rapid and highly sensitive imaging of endogenous hydrogen sulfide in living cells. Chem. Sci., 2013, 4, 2551-2556.11. Kehua Xu, Mingming Qiang, Wen Gao, Ruixian Su, Na Li, Yan Gao, Yanxia Xie, Fanpeng Kong and Bo Tang*. A Near-infrared reversible fluorescent probe for real-time imaging of redox status changes in vivo. Chem. Sci., 2013, 4, 1079-1086.12. Hui Xu, Qian Li, Lihua Wang, Yao He, Jiye Shi, Bo Tang* and Chunhai Fan*. Nanoscale optical probes for cellular imaging. Chem.Soc. Rev., 2014, 43, 2650-2661.13. Wen Gao, Lifei Ji, Lu Li, Guanwei Cui, Kehua Xu, Ping Li and Bo Tang*. Bifunctional combined Au-Fe2O3 nanoparticles for induction of cancer cell-specific apoptosis and real-time imaging. Biomaterials, 2012, 33, 3710-3718.14. Yu Ma, Hao Su, Xuan Kuang, Xiangyuan Li, Tingting Zhang, and Bo Tang*. Heterogeneous Nano Metal-Organic Framework Fluorescence Probe for Highly Selective and Sensitive Detection of Hydrogen Sulfide in Living Cells. Anal. Chem., 2014, 86, 11459-1146315. Haiyun Liu, Lu Li, Qian Wang, Lili Duan, and Bo Tang*. Graphene Fluorescence Switch-Based Cooperative Amplification: A Sensitive and Accurate Method to Detection MicroRNA. Anal. Chem., 2014, 86, 5487-5493.16. Lu Li, Qian Wang, Jie Feng, Lili Tong, and Bo Tang*. Highly Sensitive and Homogeneous Detection of Membrane Protein on a Single Living Cell by Aptamer and Nicking Enzyme Assisted Signal Amplification Based on Microfluidic Droplets. Anal. Chem., 2014, 86, 5101-5107.17. Na Li, Yanhua Li, Yaoyao Han, Wei Pan, Tingting Zhang, and Bo Tang*. A Highly Selective and Instantaneous Nanoprobe for Detection and Imaging of Ascorbic Acid in Living Cells and in Vivo. Anal. Chem., 2014, 86, 3924-3930.18. Ping Li, Wen Zhang, Kexiang Li, Xiao Liu, Haibin Xiao, Wei Zhang, and Bo Tang*. Mitochondria-Targeted Reaction-Based Two-Photon Fluorescent Probe for Imaging of Superoxide Anion in Live Cells and in Vivo. Anal. Chem., 2013, 85, 9877-9881.19. Lu Li, Feifei Gao, Jian Ye, Zhenzhen Chen, Qingling Li, Wen Gao, Lifei Ji, Ruirui Zhang, and Bo Tang*. FRET-Based Biofriendly Apo-GOx-Modified Gold Nanoprobe for Specific and Sensitive Glucose Sensing and Cellular Imaging. Anal. Chem., 2013, 85, 9721-9727.20. Haiyun Liu, Lu Li, Lili Duan, Xu Wang, Yanxia Xie, Lili Tong, Qian Wang, and Bo Tang*. High Specific and Ultrasensitive Isothermal Detection of MicroRNA by Padlock Probe-Based Exponential Rolling Circle Amplification. Anal. Chem., 2013, 85, 7941-7947.21. Wei Pan, Huijun Yang, Tingting Zhang, Yanhua Li, Na Li*, and Bo Tang*. Dual-Targeted Nanocarrier Based on Cell Surface Receptor and Intracellular mRNA: An Effective Strategy for Cancer Cell Imaging and Therapy. Anal. Chem., 2013, 85, 6930-6935.22. Xuan Kuang, Yu Ma, Hao Su, Jine Zhang, Yu-Bin Dong, and Bo Tang*. High-Performance Liquid Chromatographic Enantioseparation of Racemic Drugs Based on Homochiral Metal-Organic Framework. Anal. Chem., 2014, 86, 1277-1281.23. Zhenzhen Chen, Qingling Li, Qianqian Sun, Hao Chen, Xu Wang, Na Li, Miao Yin, Yanxia Xie, Hongmin Li and Bo Tang*. Simultaneous Determination of Reactive Oxygen and Nitrogen Species in Mitochondrial Compartments of Apoptotic HepG2 Cells and PC12 Cells Based On Microchip Electrophoresis–Laser-Induced Fluorescence. Anal. Chem., 2012, 84, 4687-4694.24. Ping Li, Shan Zhang, Nannan Fan, Haibin Xiao, Wen Zhang, Wei Zhang, Hui Wang, and Bo Tang*. Quantitative Fluorescence Ratio Imaging of Intralysosomal Chloride Ions with Single Excitation/Dual Maximum Emission. Chem. Eur. J., 2014, 20, 11760-11767.25. Xu Wang, Jianzheng Lv, Xueying Yao, Yong Li, Fang Huang, Mengmeng Li, Jie Yang, Xiuyun Ruan and Bo Tang*. Screening and investigation of a cyanine fluorescent probe for simultaneous sensing of glutathione and cysteine under single excitation. Chem. Commun., 2014, 50, 15439-15422.26. Sujuan Ye, Yanying Wu, Wen Zhang, Na Li and Bo Tang*. A sensitive SERS assay for detecting proteins and nucleic acids using a triple-helix molecular switch for cascade signal amplification. Chem. Commun., 2014, 50, 9409-9412.27. Wen Gao, Wenhua Cao, Huaibin Zhang, Ping Li, Kehua Xu and Bo Tang*. Targeting lysosomal membrane permeabilization to induce and image apoptosis in cancer cells by multifunctional Au-ZnO hybrid nanoparticles. Chem. Commun., 2014, 50, 8117-8120.28. Na Li, Huijun Yang, Wei Pan, Wei Diao and Bo Tang*. A tumour mRNA-triggered nanocarrier for multimodal cancer cell imaging and therapy. Chem. Commun., 2014, 50, 7473-7476.29. Ping Li, Haibin Xiao, Yinfang Cheng, Wen Zhang, Fang Huang, Wei Zhang, Hui Wang and Bo Tang*. A near-infrared-emitting fluorescent probe for monitoring mitochondrial pH. Chem. Commun., 2014, 50, 7184-7187.30. Hongyan Zhang, Yanhong Wang, Qingling Li, Fumiao Zhang and Bo Tang*. A size amplified immune magnetic microbeads strategy in circulating tumor cells rapid detection. Chem. Commun., 2014, 50, 7024-7027.31. Yingqiang Zhao, Ming-Yue Ma, Guan-Wei Cui*, Xi-Feng Shi, Feng-Yun Han, Xin-Yuan Xia, Bo Tang*. A New Strategy to Realize Efficient Spacial Charge Separation on Carbonaceous Photocatalyst. Carbon, 2014, 73, 333-337.32. Xi-Feng Shi, Na Li, Ke Zhao, Guan-Wei Cui, Ying-Qiang Zhao, Ming-Yue Ma, Ke-Hua Xua, Ping Li, Yu-Bin Dong*, Bo Tang*. A dye-sensitized FeOOH-CNT photocatalyst with three electron transfer channels regulated by hydrogen bonding. Appl. Catal. B: Environ., 2013, 136-137, 334-340. 1、山东省科技厅项目：新型、高效农药、医药中间体原料的合成，2003年鉴定，成果水平为国际领先。2、山东省技厅项目：中间体三氟甲基水杨酸研究，2003年鉴定，成果水平为国际领先。3、山东省科技厅项目：固定化床催化生产腈类、酮类农药、医药中间体的新工艺，2003年鉴定，成果水平为国际领先。4、山东省教育厅项目：高效低毒医药农药中间体2-羟基-4-三氟甲基苯甲酸的合成，2003年鉴定，成果水平为国际领先。5、教育部高等学校骨干教师资助计划：新型双波段光能转换薄膜材料的研究与应用，2004 年鉴定，成果水平为国际先进。6、济南市青年科技明星计划：加强农作物光合作用的新材料研究及应用，2004年鉴定，成果水平为国际先进水平。7、山东省科技发展计划发展项目：复合与单核双波段光能转换材料的中试生产及生态棚膜新产品的研发，国际先进水平。20078、山东省科技厅科技攻关项目：含氟中间体电化学合成清洁生产工艺的研究与应用，国际领先水平。20079、山东省教育厅重点项目：药物中间体三氟甲基苯胺催化法绿色生产新工艺研究，国际先进水平。200710、调控光合作用仿生态光能转换材料的研制及其在农作物种植中的应用，国际领先。2008 一、 发展提出绿色化工理论模型和创新生产工艺发展了美国科学家Trost的原子利用率理论，提出了原子利用率有效值理论模型，并将这一理论模型应用在污染排放严重的化肥及精细化学品生产领域。建立了40余种产品的新的清洁生产技术，从源头上最大程度减少了污染物排放。1.磷矿粉直接法生产N、P、K硫基或氯基三元复合肥新工艺研究研制开发出“磷矿粉直接法生产N、P、K硫基或氯基三元复合肥新工艺”。该技术解决了传统生产工艺的磷石膏堆积的环境污染问题，原子利用率有效值达到100%，成为复合肥清洁生产工艺的典范。累计创产值18.3亿元,利税1.8亿元,产生了显著的经济社会效益。2001年获国家科技进步二等奖、山东省科技进步一等奖。项目的实施，在一定程度上解决了我国当时高品质N、P、K复合肥依赖进口的问题，极大促进了复合肥行业的发展，提高了农作物的产量和农民增收。项目实施地山东省临沂地区，已成为全国复合肥生产基地。唐波教授因此荣获山东省“富民兴鲁”劳动奖章和省“优秀专业技术人员”，成为首批山东省有突出贡献的中青年专家。2.重要农药、医药中间体的绿色化工生产技术集成研究唐波教授课题组通过新型高活性、长寿命催化剂及反应助剂的研制和新型清洁电合成工艺的应用，完成了38种重要农药、医药中间体的清洁生产，实现了原子利用率有效值的最大化，最大程度上控制了产品生产过程中带来的环境污染，截至2006年已累计创产值3.13亿元，利税1.5亿元。项目的实施为精细化学品清洁生产起到了良好的示范作用，取得了显著的经济社会效益。该成果2004年获山东省科技进步一等奖，2006年获国家科技进步二等奖，2007年获山东省技术发明二等奖、山东省发明创业特等奖、国家第三届发明创业奖。唐波教授因此荣获2007年“山东省先进工作者”称号。 二、“光生态”新型棚膜应用于农业生产，实现现代生态农业根据植物光合作用原理，研究开发出“光生态”新型棚膜，减少农业生产中农药、化肥的使用量，提高农产品品质，达到增产增收的效果，解决了现有转光膜发光单一、透光率降低、因生产成本高推广应用受限等问题。2010年，该产品已在我国山东、安徽、河南、山西等地推广应用，累计实现农作物种植面积4万多亩，农产品收入6亿元，以增产15%计算，农户增收9000万元，取得了显著的经济社会效益，对于增加农民收入，实现科技兴农，发展低碳经济，实现生态农业具有重要意义。该成果获山东省“百千万富民工程杯”金奖，山东省专利奖二等奖；2010年，项目获山东省技术发明一等奖。 三、应用于生物成像的分子及纳米荧光探针的合成与应用致力于新颖实用的分子、纳米荧光探针研究，并将成果用于细胞及活体组织内多种重要生命相关物质的成像检测。相关研究成果发表于J.Am.Chem.Soc.等世界知名的化学类综合期刊，引起了国内外同行的广泛关注。研究成果被J.Am.Chem.Soc., Chem. Rev., Proc. Natl. Acad. Sci. USA, Angew. Chem. Int. Ed., Adv. Mater.等著名期刊多次引用。美国霍普金斯大学、东京大学、美国农业部林产品实验室、法国、德国等多个科研机构来函索要所合成的探针。研究成果获2008年山东省自然科学一等奖。 指导博士后10余名,已培养获得博士学位的研究生14名，获得硕士学位的研究生90余名，毕业的硕士生中有5人的毕业论文评选为山东省优秀硕士论文，有1人的科研成果被评为2006年山东省首届研究生优秀科研创新成果一等奖，有多人考入佐治亚州立大学、弗吉尼亚理工大学、新加坡国立大学、清华大学、北京大学、中国科学院、南开大学、南京大学的博士研究生或从事博士后研究，2006年被评为山东省首届优秀研究生指导教师。