The progress of human society, the growth of demand and raise the level of science and technology, the traditional knowledge and genetic resources of great value for the world wide cognition, gradually in the 1980s, traditional knowledge and genetic resources has been regarded as the common wealth of mankind, the collection and utilization are free of any state, biological plagiarism, business results HuiYi share of injustice, serious problems of international society widespread concern. Developed countries businesses and scientific research institutions is the use of traditional knowledge and genetic resources of the main beneficiaries. They use of its own strong technical force, and funds from developing countries gain valuable low cost of traditional knowledge and genetic resources, develop new products and business development, an application for a patent, obtain considerable market profits. Meanwhile, traditional knowledge as the owner of the aboriginal community, and did not have the physical and mental, and his generation have traditional knowledge is business patent enjoy, this is a kind of extremely unbalanced material exchange relationship. Do great harm to the protection of traditional knowledge of the native community, therefore, the protection of traditional enthusiasm is crucial, and knowledge through intellectual property protection should be. This paper adopted the method of theory and practice, systematically and comprehensively expounded by intellectual property protection of traditional knowledge model of feasibility and concrete measures, and existing problems in the law is proposed. The article consists of five parts: The first part is introduction, the paper studies systematically introduces the background, the study of meaning and purpose, research methods and processes. The second part is related to clear this theory, the theoretical basis. First to traditional knowledge related terms, the study aims to clarify, protection, Secondly the urgency of the protection of traditional knowledge clearly, the importance and significance of the study to clarify. Then the international organizations and research, the aim is to understand the international research achievements, to lay the theoretical foundation is studied in this paper. Finally, the list of the existing international intellectual property protection of traditional knowledge model. The third part of traditional and modern knowledge through the comparison between them knowledge of clear differences, so as to further illustrate traditional knowledge and intellectual property system, which is also the conflict between many scholars opposed using intellectual property protection of traditional knowledge, the author will based on thorough analysis, in order to find the breakthrough, to prove the conflict of intellectual property protection of traditional knowledge using the feasibility. The fourth part for the core, mainly in the above analysis, the research based on intellectual property rights protection system established by the principles and ways of traditional knowledge. The fifth part is the conclusions and recommendations, mainly including the main contribution of this study, and prospects.Keywords: genetic resources of traditional knowledge biodiversity of intellectual property