中国药学杂志审稿人

中国毒理学会理事，中国药学会应用药理专业委员会委员，中国毒理学会生殖毒理专业委员会副主任委员，中国药理学会药物毒理专业委员会委员。浙江省药学会药理专业委员会主任委员，浙江省药理学会副理事长，浙江省药学会医院药学专业委员会委员。《Acta Pharcologica Sinica》（SCI收录）5，6，7届编委，《European Journal Pharmacology》（SCI收录）特邀注册审稿人，《Toxicology》（SCI收录）特邀注册审稿人，《中国药理学与毒理学杂志》编委，《浙江大学学报（医学版）》编委。 干细胞生物学与再生医学/药物发现；心脑血管与肝脏药理机制及新药研究；基于系统生物学的药物毒理学研究。 2009-2011：国家自然科学基金重大研究计划《基于诱导ES细胞定向分化的化合物库构建和信号转导分子事件发现》（№ 90813026，基于化学小分子探针的信号转导过程研究专项-培育项目，合作负责人）2007-2009：国家自然科学基金课题《ES细胞衍生肝组织系统微粒体GST表达谱及其药物调控特征》（№ 30672564，项目负责人）；2007-2009：浙江省“十一五”重点项目中药现代化专项《抗老年痴呆五类中药新药研发》（№2006C13075，项目总负责人）；2005-2007：国家自然科学基金课题《肝膜蛋白mGST介导白三烯旁分泌/自分泌环路及其药物调控》（№30472112，项目负责人）；2005-2006：“十五”国家科技攻关计划重点项目《中医药疗效及安全性基本问题研究》项目，参加“含马兜铃酸药材中成药安全性评价示范研究”机制研究内容；2004-2006：商务部援印度尼西亚天然药物植物研究与开发项目《护肝活性成分和抗糖尿病活性成分筛选与新药研发》（合同号：（2004）援外成字第020号，分项目负责人）；2003-2006：国家自然科学基金中德科学基金课题《中国蔬菜中黄酮和相关多酚防治疾病活性成分研究》 [NSFC-DFG基金 №GZ051-3（147），项目负责人]；2003-2004：教育部科学技术研究重点项目《干细胞定向分化心肌细胞药效筛选模型应用研究》（№03088，项目负责人）；2003-2004：浙江省重点科研计划国际合作项目《胚胎干细胞定向分化心肌细胞模型在中药活性成分评价中的应用研究》（№2003C24005，项目负责人）；2002-2004：国家自然科学基金课题《药物介导胚胎干细胞体外定向分化的干预效应研究》（№30171121，项目负责人）；2002-2004：“十五”国家攻关计划引导项目《花粉中抑制前列腺肿瘤增生的有效成分分离及新药开发》（任务书编号：2002BA760C，第一参加单位项目负责人）；2001-2003：国家自然科学基金课题《微粒体GST修饰激活及其对外源性物质转化的相关性》（№30070904，项目负责人）；1999-2001：《微粒体膜GST生物学特性与肿瘤化疗药物抗性的相关性研究》（教育部留学回国人员基金，教外司留[1998]679号）；1995-1997：国家自然科学基金课题《药源性哺乳动物着床前胚泡异常对胎仔发育影响机制研究》（№39470836，项目负责人）；1992-1994：国家自然科学基金课题《药源性哺乳动物着床前胚泡异常对胎仔发育影响研究》（№39170875，项目负责人）； 1．WO Yan-Bo, ZHU Dan-Yan, HU Ying, WANG Zhi Qiang, LIU Jian, LOU Yi-Jia*: Reactive oxygen species involved in prenylflavonoids icariin, icaritin initiated cardiomyocytes differentiation of mouse embryonic stem Journal of Cellular Biochemistry 2008;103(5):1536-2．Yandong Zhang, Zhe Chen, Yijia Lou*, YongpingYu*: 2,3-Disubstituted 8-arylamino-3H-imidazo[4,5-g]quinazolines: a novel class of antitumor European Journal of Medicinal Chemistry 2008;（in press, doi:1016/009）3．Ming Zheng, Linhai Qu, Yijia Lou*: Effects of icariin combined with the Panax notoginseng saponins on ischemia reperfusion-induced cognitive impairments related with oxidative stress and CA1 of hippocampal neurons in Phytotherapy Research 2008;22(5):597-4．Danyan Zhu, Yue Du, Xin Huang, Meiyuan Guo,kuifen Ma, Yongping Yu, Yijia Lou*：MAPEG Expression in Murine Embryonic Stem Cell-Derived Hepatic Tissue S Stem cells and Development 2008;17(4):775-5．Ling Ding, Xingguang Liang, Ying Hu, Danyan Zhu, Yijia Lou*: Involvement of p38MAPK and reactive oxygen species in icariin-induced cardiomyocyte differentiation of murine embryonic stem cells in Stem cells and Development 2008;（in press, doi:1089/0206）6．Yanbo Wo, Danyan Zhu, Yongping Yu, Yijia Lou*: Involvement of NF-κB and AP-1 activation in icariin promoted cardiac differentiation of mouse embryonic stem Eur J P 2008;31;586(1-3):59-7．Kuifen Ma, Ziqi Ye, Zhe Chen, Luoyang Qi, Danyan Zhu, and Yijia Lou*Enhanced expressions and activations of leukotriene C4 synthesis enzymes in D-galactosamine/ lipopolysaccharide induced rat fulminant hepatic failure World J Gastroenterology 2008;14(7):2748-8．Ling Ding, Xingguang Liang, Danyan Zhu, Yijia Lou* Icariin promoted expression of PGC-1α, PPARα, and NRF-1 during cardiomyocyte differentiation of murine embryonic stem cells in Acta Pharmacologica Sinica 2007;28(10):1541-9．Ding Ling; Liang Xingguang, Zhu Danyan, Lou Yijia*: Peroxisome proliferator-activated receptor α is involved in cardiomyocyte differentiation of murine embryonic stem cells in Cell Biology International 2007; 31:1002-10．Qing-wei Zhao, Xin Huang, Yij-ia Lou*, Weber Nadine, Peter Proksch: Effects of Ethanol Extracts from Adzuki Bean (Phaseolus angularis W) and Lima Bean (Phaseolus lunatus L) on Estrogen and Progesterone Receptor Phenotypes of MCF-7 /BOS C Phytotherapy Research 2007; 21:648-11．Jiang Guo-Jun, Li Tie-jun, Qiu Yan, Chen Wan-Sheng, Lou Yi-Jia*: RNA interference for HIF-1α inhibits foam cells formation in Eur J P 2007;562(3):183-12．Xin Huang, Danyan Zhu, Yijia Lou*: A Novel Anticancer Agent, Icaritin, Induced Cell Growth Inhibition, G1 Arrest and Mitochondrial Transmembrane Potential Drop in Human Prostate Carcinoma PC-3 C Eur J P 2007;564:26-13．Ling DING, Xing-guang LIANG, Yi-jia LOU*: Time-dependence of cardiomyocyte differentiation disturbed by peroxisome proliferator-activated receptor α inhibitor GW6471 in murine embryonic stem cells in Acta Pharmacologica Sinica 2007;28(5):634-14．Yao-Dong WU, Yi-Jia LOU*：A Steroid Fraction of Chloroform Extract from Bee Pollen of Brassica Campestris L Induces Cell Cycle Arrest and Apoptosis in Human Prostate Cancer PC-3 C Phytotherapy Research 2007;21(11):1087-15．Shulong Yang, Li-jun Chen, Yin Kong, Dan Xu, Yijia Lou*: Sodium nitroprusside regulated the mRNA expression of LTC4 synthase in hepatic I/R injury rats via NF-kB signaling Pharmacology 2007; May,80(1):11-16．Shulong Yang, Xin Huang, Hai-Fei Chen, Dan Xu, Li-Jun Chen, Yin Kong,Yijia Lou*: Increased Leukotriene C4 Synthesis Accompanied Enhanced Leukotriene C4 Synthase Expression and Activities of Ischemia-Reperfusion Injured Liver in RJournal of Surgical Research 2007; 140(1):36-17．朱丹雁*，楼宜嘉：淫羊藿苷诱导小鼠胚胎干细胞体外定向分化为心肌细胞方法学研究 中国药学杂志 2007;42(9):29-18．W Wätjen*, N Weber, Y-J Lou, Z- Wang, Y Chovolou, A Kampkötter, R Kahl, P Proksch: Prenylation enhances cytotoxicity of apigenin and liquiritigenen in rat H4IIE hepatoma and C6 glioma Food and Chemical Toxicology 2007;45(1):119-19．史 强，楼宜嘉*：活性氮对肝脏微粒体GST1修饰激活的研究进展 中国药理学与毒理学杂志 2007;21(4):297-20．Yao-Dong WU, Yi-Jia LOU*: Brassinolide, a plant sterol from pollen of Brassica napus L, induces apoptosis in human prostate cancer PC-3 PHARMAZIE 2007;62(5):392-21．Zhiqiang Wang, Xiangnan Zhang, Luoyang Qi, Huanhuan Wang, Yijia Lou*: Neuroprotective effects of icaritin against beta amyloid-induced neurotoxicity in primary cultured rat neuronal cells via estrogen-dependent N 2007; 145:911-22．Hao-shu Wu, Ying-yin Li, Lin-jia Weng, Chang-xin Zhou, Qiao-jun He, Yi-jia Lou*: Ethyl acetate fraction of Acrous Calamus L extract enhance adipocyte differentiation in 3T3-L1 Phytotherapy Research 2007;21(6):562-23．Shulong Yang, Yijia Lou*: Sodium Nitroprusside Decreased Leukotriene C4 Generation by Inhibiting Leukotriene C4 Synthase Expression and Activity in Hepatic Ischemia-Reperfusion Injured R Biochemical Pharmacology 2007;73:724–24．楼宜嘉*，陈 哲：细胞组学与药理毒理学研究新机遇 浙江大学学报（医学版）2007;36(3):209-25．朱丹雁，张翔南，杜悦，陈燕，王志强，楼宜嘉：淫羊藿素诱导小鼠胚胎干细胞体外定向分化为神经细胞 浙江大学学报（医学版）2007;36(3):217-26．张翔南，王欢欢，王志强，吴佳莹，朱丹雁，楼宜嘉*：淫羊藿素抗Aβ肽致大鼠原代培养神经细胞凋亡作用 浙江大学学报（医学版）2007;36(3):224-27．郭美媛，朱丹雁，杜悦，楼宜嘉*：微粒体Ⅱ相代谢酶基因在小鼠胚胎干细胞定向分化肝细胞中的表达 浙江大学学报（医学版）2007;36(3):229-28．马葵芬，张相宜，齐罗扬，王燕，周长新，NINA Artanti，NOVIK Nurhidayat，LINCE Yarni，楼宜嘉*：三萜类化合物对化学损伤原代培养大鼠肝细胞的保护作用 浙江大学学报（医学版）2007;36(3):247-29．齐罗扬 马葵芬 来芳芳杜 悦 朱丹雁 楼宜嘉*：刀豆蛋白A致小鼠肝损伤的白三烯C4合成酶系基因表达及环孢素A调控作用 浙江大学学报（医学版）2007;36(3):241-30．陈 哲，叶子奇，史强，朱丹雁，楼宜嘉*：大鼠微粒体谷胱甘肽S-转移酶1对苯丁酸氮芥体外致肿瘤细胞毒性的影响 浙江大学学报（医学版）2007;36(3): 236-31．Jie Zhang, Yijia Lou, Jos Hoogmartens, Ann Van Schepdael: Screening of drug metabolism by CE Electrophoresis 2006;27(23):4827-32．Meihua Bao, Yijia Lou*: Isorhamnetin prevent endothelial cell (EAhy926) injuries from oxidized LDL via activation of p38MAPKEuropean J Pharmacology 2006;547(1-3):22-30；33．Qiang shi, Haifei Chen, Yijia Lou*: Further evidence that rat liver microsomal glutathione transferase 1 is not a cellular protein target for S- Chemico-Biological Interactions 2006;162:228-34．Meihua Bao, Yijia Lou*: Flavonoids from Seabuckthorn protect endothelial cells (EAhy926) from oxidized low-density lipoprotein induced injuries via regulation of LOX-1 and eNOS Journal of Cardiovascular Pharmacology 2006;48(1):834-35．何旭东，吴洪海，楼宜嘉*：阿伐他汀伍用大豆异黄酮对实验性高血脂动物的调血脂作用及相关机制研究 中国药理学与毒理学杂志 2006;20(5)：381-36．沃燕波，朱丹雁，张翔南，楼宜嘉*：光电成像系统在评价胚胎干细胞体外定向分化为心肌细胞中的应用 中国药理学与毒理学杂志 2006；20（6）:504-37．肖幸丰，王志强，楼宜嘉*：淫羊藿苷伍用三七总皂苷对小鼠免疫功能的调节作用中草药 2006；37(6):233-38．Zhiqiang Wang, Nadine Weber, Yijia Lou*, Peter Proksch: Prenylflavonoids as Non-Steroidal Phytoestrogen and Related Structure-activity R ChemMedChem 2006;1(4):482-39．Danyan Zhu, Yijia Lou*: Icariin-mediated expression of cardiac genes and modulation of nitric oxide signaling pathway during differentiation of mouse embryonic stem cells into cardiomyocytes in Acta Pharmacologica Sinica 2006;27(3):311-40．Zhang J, Ha PT, Lou Y, Hoogmartens J, Van Schepdael A*: Kinetic study of cytochrome P450 3A4 activity on warfarin by capillary electrophoresis with fluorescence J Chromatogr A 2005;1082(2):235-41．Jie Zhang, Pham Thi Thanh Ha, Yijia Lou, Jos Hoogmartens, Ann Van Schepdael*: Kinetic study of CYP3A4 activity on verapamil by capillary Journal of Pharmaceutical and Biomedical Analysis 2005;39:612–42．Qing-wei Zhao, Bo Li, Nading Weber, Yi-jia Lou*, Prter Proksch: Estrogen-like effects of ethanol extracts from several Chinese legumes on MCF-7 European Food Research and Technology 2005;221(6):828-43．Haiyun Ling, Yijia Lou*: Total flavones from Elsholtzia blanda reduce infarct size during acute myocardial ischemia by inhibiting myocardial apoptosis in J Ethnopharmacology 2005;101:169-44．Danyan Zhu, Linhai Qu, Xiangnan Zhang, Yijia Lou*: Icariin-madiated modulation of cell cycle and p53 during cardiomyocyte differentiation in embryonic stem Eur J P 2005; 514:99-45．Haiyun Ling, Yijia Lou*, Honghai Wu, Honggang Lou: Total flavones from Elsholtzia blanda reduce infarct size and improve heart function during acute myocardial infarction by inhibiting myocardial apoptosis in canines Acta Cardiologica 2005; 60(3):295-46．Haiyong Ye, Yijia Lou*: Estrogenic effects of two derivatives of icariin on human breast cancer MCF-7 cells Phytomedicine 2005;12:735-Jie Zhang, Zhiwei Ye, Yijia Lou*: Metabolism of malphalan by rat liver microsomal glutathione S- Chemico-Biological Interactions 2005;152：101-106；48．叶海涌，楼宜嘉*：淫羊藿苷衍生物的制备及其雌激素样作用研究 浙江大学学报（医学版） 2005;34(2)131-49．Danyan Zhu, Yijia Lou*: Inducible effects of icariin, icaritin, and desmethylicaritin on directional differentiation of embryonic stem cells into cardiomyocytes in vitro Acta Pharmacologica Sinica 2005;26(4):477-50．Qiang Shi, Yijia Lou*: Microsomal glutathione Transferase 1 is notS-nitrosylated in rat liver microsomes or in endotoxin challenged Pharmacological Research 2005;51(4):303-51．Jian Liu, Haiyong Ye, Yijia Lou*: Determination of rat urinary metabolites of icariin in vivo and estrogenic activities of its metabolites on MCF-7 Die Pharmazie 2005;60(2):120-52．Zhiqiang Wang, Yijia Lou*: Proliferation-stimulating effects of icaritin anddesmethylicaritin in MCF-7 cells Eur J P 2004; 504:147-53．Jian Liu, Yi-jia Lou*: Determination of icariin and metabolites in rat serum by capillary zone electrophoresis: rat pharmacokinetic studies after administration of J Pharmaceutical and Biomedical Analysis 2004; 36:365-54．Jie Zhang, Zhiwei Ye, Yijia Lou*: Metabolism of chlorambucil by rat liver microsomal glutathione S- Chemico-Biological Interactions 2004; 149:61-67；55．Ling Haiyun, Lou Yijia*, Lou Honggang, Wu Honghai: Protective effect of total flavones from Elsholtzia blanda (TFEB) on myocardial ischemia induced by coronary occlusion in J Ethnopharmacology 2004;94(1);101-56．Qinzhu Zheng, Yijia Lou: Pathologic characteristics of immunologic injury in primary cultured rat hepatocytes and hepatoprotection of Glycyrrhizin from cytotoxicity in Acta Pharmacologica Sinica 2003;24(8):771-57．Jie Zhang, Yi-Jia Lou: Relationship between activation of microsomal glutathione S-transferase and metabolism behavior of Pharmacological Research 2003;48:623- 1．全国高等医药规划教材《药物毒理学》，人民卫生出版社，2003，第一版；2007年，第二版（“十一五”国家重点建设高等教育规划教材）。2．全国高等医药教育规划教材《新药临床前评价教程》（药理与毒理学评价过程），浙江大学出版社，2007（面向21世纪精品课程教材，应用型本科规划教材）。参编著作：1．周宏灏主编：临床医学专业卫生部规划教材·英文版《Pharmacology》，人民卫生出版社，2007；第一版。承担二个章节编写。2．潘家祜，李学军主编：研究生规划教材《生化与分子药理学》，复旦大学出版社，2008（“十一五”国家重点建设高等教育规划教材），承担：第六章 微粒体药理学；第十六章 生化与分子药理学的关键技术，第三节 干细胞研究技术。国际与全国会议： Xiangnan Zhang, Jiaying Wu, Huanhuan Wang, Gerald Rimbach, Yijia Lou 1*: Asiatic acid attenuated Ceramide induced Neurotoxicity and Caspase 3 activation in Primary cultured rat Neuronal C Nutrition Genomics O SEP, 2008, Potsdam,德国2．Lily Ou, Yijia Lou, Yongping YU*: Design, synthesis and effects on directional differentiation of embryonic stem cells of Icaritin D SINO-French Workshop on Bioorgannic and Medicinal C OCT 2007; P Hangzhou, C3．Yandong Zhang, Zhe Chen, Jieping Yan, Ziqi Ye, Yongping Yu*, Yijia Lou*：Solid-phase Synthesis and Biological Evaluation of Quinazoline D SINO-French Workshop on Bioorgannic and Medicinal C OCT 2007;;P Hangzhou, C4．Zhiqiang Wang, Jiaying Wu, Minhua Xu, Yijia Lou*：Prenylflavonoids as Nonsterodal Phytoestrogens and Relataed Struture-Activity Relationship第三届国际分子模拟与信息技术应用学术会议 MAR Hangzhou, C5．YIjia Lou, Stem cell biology and drug discovery 1st Asian-Link Workshop for Marine Natural Products and Medicinal Plants AGU Beijing C 20-6．第三届全国干细胞移植在心血管疾病应用研讨会，大会特邀专题报告《干细胞生物学与药物研究》2007年11月，杭州。 Yijia Lou*, Yaodong Wu: Antitumor and immunomodulatory activities of polysaccharide-protein complex from bee pollen of Brassica campestris L ONCOLOGY RESEARCH (Meeting Abstract) 2006;15(10-12):8．Xin Huang, Zhiqiang Wang, Danyan Zhu, Yijia Lou*: Cytotoxic effects of icariin and isobavachin on pc-3 cell The International Congress of Asian Society of T JUN 2006; Zhuhai, C Zhe Chen, Luoyang Qi, Danyan Zhu, Yijia Lou*: Relationship between activation of microsomal glutathione S-transferase and development of drug resistance on PC-3, K-562 and HepG2 cell The International Congress of Asian Society of T JUN 2006; Zhuhai, C Haifei Chen, Yijia Lou*: Activation of microsomal glutathione S-transferase 1 by acetaminophen overdose is associated with protein dimmer formation in rat primarily cultured The International Congress of Asian Society of T JUN 2006; Zhuhai, C Qiang Shi, Yijia Lou*: Activation of microsomal glutathione S-transferase 1 by acetaminophen overdose is associated with protein dimmer formation but not metabolite The International Congress of Asian Society of T JUN 2006; Zhuhai, C N Weber , W Wätjen, R Edrada ,V Wray, Y Lou, Z- Wang and P Proksch: Flavonoids from Vigna angularis – composition and antioxidative effects The congress of the 54th Annual Meeting of the Society for Medicinal P 2006; H F Ling Ding, Xinguang Liang, Danyan Zhu, Yijia Lou*: Peroxisome proliferator-activated receptor alpha is involved in cardiomyocyte differentiation of murine embryonic stem cells in The 5th Asian-Pacific Organization for Cell Biolog C OCT Beijing, C Kui-fen Ma, Luo-yang Qi, Dan-yan Zhu, Lin-hai Qu, Yi-jia Lou*: Cysteinyl Leukotrienes Autocrine Loop Associated with Microsomal Glutatione S-transferase-Ⅱ in Rat H XI‘AN SATELLITE MEETING OF THE 15th WORLD CONGRESS OF PHARMACOLOGY，2006，Xi’an, C 111- Zhe Chen, Danyan Zhu, Yijia Lou*: Cytotoxic effects of chlorambucil on PC-3, K562, HepG2, and P388D1 cell lines affected by rat microsomal glutathione S-transferase The Second Asia-Pasific Forum on Andrology, Shanghai，C Xin Huang, Zhiqiang Wang, Danyan Zhu, Yijia Lou*: Anti-carcinoma activities of icariin, icaritin and isobavachin on PC-3 cell The Second Asia-Pasific Forum on Andrology, Shanghai，C17．羊红玉，刘璐璐，朱丹雁，楼宜嘉*：Beagle 犬单次口服青木香或冠心苏合胶囊马兜铃酸I毒代动力学研究。中国毒理学会第二届中青年学者科技论坛。2007年10月：3618．叶子奇，陈海飞，陈哲，朱丹雁，楼宜嘉*：过量对乙酰氨基酚致大鼠原代培养肝细胞与人肝癌细胞HepG2 mGST1修饰激活机制研究。中国毒理学会第二届中青年学者科技论坛。2007年10月：117 1．《淫羊藿苷在诱导胚胎干细胞体外定向分化方面的用途》授权公告日：2004年9月1日，专利号：ZL 02 1 7；2．《淫羊藿素或去甲淫羊藿素在制备雌激素受体调节剂中的应用》授权公告日：2005年3月30日，专利号：ZL 03 1 9；3．《鸡肝散提取物总黄酮在制备抗心血管疾病药中的应用》授权公告日：2006年2月15日，专利号：ZL 02 1 4；4．《含辛伐他汀、泛硫乙胺和黄酮类的组合物及其用途》专利号：ZL 02 1 4；5．《鸡肝散提取物总黄酮在制备抗眼科疾病药中的应用》公开号：CN1757402，公开日：12；6．《一种水菖蒲有效部位提取物及其用途》公开号：CN1973877, 公开日：2007年6月6日；7．《淫羊藿总黄酮与三七总皂苷组合物的应用》（调节代谢型谷氨酸受体自身受体作用）公开号： CN101229210, 公开日：30；8．《8-芳胺基-3H-咪唑[4,5-g]喹唑啉类衍生物的用途》（在制备抗肿瘤药物中应用）公开号：CN101120945，公开日：13；9．《 喹唑啉咪唑化合物的用途》（组合化学库内化合物诱导胚胎干细胞定向分化心肌细胞）公开号：CN101254191，公开日：03；