Along with the information technology in the management of a more profound and extensive application of management information system in the implementation of technology has gradually Management information system is a continuous development of new discipline, any unit to survive is to develop and efficient activities of the internal organization of organic, it must establish its own characteristics in line with the management information Suitable for the development of the school for the school to students' information management system, through such systems, can achieve the information management, scientific and quick inquiry, and reduce the workload of Based on VB of object-oriented programming environment and Access database design student management system, using the software engineering principles, using lifecycle methodology, according to the pattern design 3NF relation database table, modular design way with each function modules of the system, design a system decomposition layers, and based on the modular structure of the system and the need to achieve specific requirements, the function of each module defines the specific System mainly includes the establishment and the maintenance and the programming of the frontend application, realize the student information database and the information related to students, deleting, add, modify and inquires, system has powerful, friendly interface, and simple operation