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代表性论文 Zeng, H. L., Rao, X., Zhang, L. K., Zhao, X., Zhang, W. P., Wang, J., Xu, F., and Guo, L. (2014) Quantitative proteomics reveals olfactory input-dependent alterations in the mouse olfactory bulb proteome, J Proteomics 109, 125-142Yao, Q., Liu, B. Q., Li, H., McGarrigle, D., Xing, B. W., Zhou, M. T., Wang, Z., Zhang, J. J., Huang, X. Y., and Guo, L. (2014) C-terminal Src kinase (Csk)-mediated phosphorylation of eukaryotic elongation factor 2 (eEF2) promotes proteolytic cleavage and nuclear translocation of eEF2, J Biol Chem 289, 12666-12678Zhao, X., Sidoli, S., Wang, L., Wang, W., Guo, L., Jensen, O. N., and Zheng, L. (2014) Comparative proteomic analysis of histone post-translational modifications upon ischemia/reperfusion-induced retinal injury, J Proteome Res 13, 2175-2186Yan, J., Tian, H., Wang, S., Shao, J., Zheng, Y., Zhang, H., Guo, L., and Ding, Y. (2014) Pollen developmental defects in ZD-CMS rice line explored by cytological, molecular and proteomic approaches, J Proteomics 108C, 110-123Zhang, L. K., Chai, F., Li, H. Y., Xiao, G., and Guo, L. (2013) Identification of host proteins involved in Japanese encephalitis virus infection by quantitative proteomics analysis, J Proteome Res 12, 2666-2678Xing, B., Wang, L., Guo, D., Huang, J., Espenel, C., Kreitzer, G., Zhang, J. J., Guo, L., and Huang, X. Y. (2013) Atypical protein kinase Clambda is critical for growth factor receptor-induced dorsal ruffle turnover and cell migration, J Biol Chem 288, 32827-32836Wu, Y., Zhao, S., Tian, H., He, Y., Xiong, W., Guo, L., and Wu, Y. (2013) CPK3-phosphorylated RhoGDI1 is essential in the development of Arabidopsis seedlings and leaf epidermal cells, J Exp Bot 64, 3327-3338Li, X. S., Pan, Y. N., Zhao, Y., Yuan, B. F., Guo, L., and Feng, Y. Q. (2013) Preparation of titanium-grafted magnetic mesoporous silica for the enrichment of endogenous serum phosphopeptides, J Chromatogr A 1315, 61-69Hou, D., Zhang, L., Deng, F., Fang, W., Wang, R., Liu, X., Guo, L., Rayner, S., Chen, X., Wang, H., and Hu, Z. (2013) Comparative Proteomics Reveal Fundamental Structural and Functional Differences between the Two Progeny Phenotypes of a Baculovirus, J Virol 87, 829-839Chen, X., Zhao, Y., Li, ., and Guo, L. (2013) Proteomic analysis of mismatch repair-mediated alkylating agent-induced DNA damage response, Cell & Biosciences 3, 37Xu, H., Zhang, W., Gao, Y., Zhao, Y., Guo, L., and Wang, J. (2012) Proteomic analysis of embryo development in rice (Oryza sativa), Planta 235, 687-701Liu, G., Tian, H., Huang, Y. Q., Hu, J., Ji, Y. X., Li, S. Q., Feng, Y. Q., Guo, L., and Zhu, Y. G. (2012) Alterations of Mitochondrial Protein Assembly and Jasmonic Acid Biosynthesis Pathway in Honglian (HL)-type Cytoplasmic Male Sterility Rice, J Biol Chem 287, 40051-40060Kang, X., Chen, X., He, Y., Guo, D., Guo, L., Zhong, J., and Shu, H. B. (2012) DDB1 is a cellular substrate of NS3/4A protease and required for hepatitis C virus replication, VirologyChen, C., Wu, D., Zhang, L., Zhao, Y., and Guo, L. (2012) Comparative phosphoproteomics studies of macrophage response to bacterial virulence effectors, J Proteomics 77, 251-261Yu, J. L., and Guo, L. (2011) Quantitative proteomic analysis of Salmonella enterica serovar Typhimurium under PhoP/PhoQ activation conditions, J Proteome Res 10, 2992-3002Yao, Q., Li, H., Liu, B. Q., Huang, X. Y., and Guo, L. (2011) SUMOylation-regulated Protein Phosphorylation, Evidence from Quantitative Phosphoproteomics Analyses, J Biol Chem 286, 27342-27349Xu, H., Zhang, W., Gao, Y., Zhao, Y., Guo, L., and Wang, J. (2011) Proteomic analysis of embryo development in rice (Oryza sativa), PlantaWu, J. H., Li, X. S., Zhao, Y., Zhang, W., Guo, L., and Feng, Y. Q. (2011) Application of liquid phase deposited titania nanoparticles on silica spheres to phosphopeptide enrichment and high performance liquid chromatography packings, J Chromatogr A 1218, 2944-2953Shao, J., Zhang, Y., Yu, J., Guo, L., and Ding, Y. (2011) Isolation of Thylakoid Membrane Complexes from Rice by a New Double-Strips BN/SDS-PAGE and Bioinformatics Prediction of Stromal Ridge Subunits Interaction, PLoS One 6, e20342Chen, X., Wu, D., Zhao, Y., Wong, B. H., and Guo, L. (2011) Increasing phosphoproteome coverage and identification of phosphorylation motifs through combination of different HPLC fractionation methods, J Chromatogr B Analyt Technol Biomed Life Sci 879, 25-34Wu, J. H., Zhao, Y., Li, T., Xu, C., Xiao, K., Feng, Y. Q., and Guo, L. (2010) The use of liquid phase deposition prepared phosphonate grafted silica nanoparticle-deposited capillaries in the enrichment of phosphopeptides, J Sep Sci 33, 1806-1815Wang, R., Deng, F., Hou, D., Zhao, Y., Guo, L., Wang, H., and Hu, Z. (2010) Proteomics of the Autographa californica nucleopolyhedrovirus budded virions, J Virol 84, 7233-7242Ma, Y., Zhao, Y., Zhao, R., Zhang, W., He, Y., Wu, Y., Cao, Z., Guo, L., and Li, W. (2010) Molecular diversity of toxic components from the scorpion Heterometrus petersii venom revealed by proteomic and transcriptome analysis, Proteomics 10, 2471-2485Zhou, Z., Fan, J. B., Zhu, H. L., Shewmaker, F., Yan, X., Chen, X., Chen, J., Xiao, G. F., Guo, L., and Liang, Y. (2009) Crowded cell-like environment accelerates the nucleation step of amyloidogenic protein misfolding, J Biol Chem 284, 30148-30158Deng, M., Li, F., Ballif, B. A., Li, S., Chen, X., Guo, L., and Ye, X. (2009) Identification and functional analysis of a novel cyclin e/cdk2 substrate ankrd17, J Biol Chem 284, 7875-7888Lin, B., Li, T., Zhao, Y., Huang, F. K., Guo, L., and Feng, Y. Q. (2008) Preparation of a TiO2 nanoparticle-deposited capillary column by liquid phase deposition and its application in phosphopeptide analysis, J Chromatogr A 1192, 95-102Deng, F., Wang, R., Fang, M., Jiang, Y., Xu, X., Wang, H., Chen, X., Arif, B. M., Guo, L., and Hu, Z. (2007) Proteomics analysis of Helicoverpa armigera single nucleocapsid nucleopolyhedrovirus identified two new occlusion-derived virus-associated proteins, HA44 and HA100, J Virol 81, 9377-9385
1、曹云, 邵肖梅, 吴月等 重度窒息新生儿血液流变/血小板活化及止血状态研究 中华围产医学杂志 1998 1(2): 102-104 (获得1998年度中华围产医学杂志优秀论文三等奖)2、曹云, 邵肖梅. 环境刺激对缺氧缺血性脑损伤新生大鼠突触超微结构的影响 中国优生优育杂志 2000 11(3): 104-1073、曹云, 邵肖梅, 梅镇彤, 周文浩. 环境刺激对缺氧缺血性脑损伤新生鼠脑功能的影响 中华儿科杂志 2001 39(7): 387-3944、CAO Yun, SHAO Xiaomei, MEI Zhentong, ZHOU Wenhao. Environmental stimulation may improve functional deficits induced by hypoxic-ischemic brain damage in neonatal rats. Chin J Pediatr 2001 39(suppl): 34-375、曹云, 邵肖梅, 周蓓华, 冯玲英, 李惠蓉 新生儿缺氧缺血性脑病早期康复干预的临床疗效观察 中国实用儿科杂志 2002, 17(3): 167-1696、曹云, 邵肖梅, 梅镇彤 .外源性神经节苷脂对缺氧缺血性脑损伤新生鼠学习记忆的影响 中华围产医学杂志 2002, 5(4): 297-3007、Cao Y, Gunn AJ, Bennet L et al. Insulin-like growth factor-1 prevents post-ischemic white matter injury by preventing glial apoptosis and promoting glial proliferation in near term fetal sheep. J Cereb Blood & Metab 2003 Jun;23(6):739-478、Cao Y, Gunn AJ, Bennet L et al. Insulin-like growth factor-1 reduces -amyloid precursor protein expression after ischemic white matter damage in near-term fetal sheep. Chin J Contemp Pediatr 中国当代儿科杂志 2004, 6(6):449-4529、专家论坛:曹云 新生儿重症监护室中的发育支持护理。 实用儿科临床杂志 2005,20(8):729-73110、参与课题“围产期缺氧缺血脑损伤早期诊断和防治研究” 获2003年上海医学科技奖二等奖
1. 丁月霞,张丽,叶翠飞,王文,李林*.山茱萸环烯醚萜苷对穹窿海马伞切断大鼠海马区神经元存活和细胞凋亡调控因子的影响. 首都医科大学学报. 2011,32(1):73-78.核心期刊2. 刘莹,张兰,李雅莉,李林*.淫羊藿苷对基因转染P12细胞α-突触核蛋白过表达和泛素-蛋白酶体系统的影响. 首都医科大学学报. 2011,32(1):79-83.核心期刊3. 尹琳琳,林丽莉,王蕾,李林*.实验性自身免疫性脑脊髓炎大鼠模型的建立及病理特征. 首都医科大学学报. 2011,32(1):84-89.核心期刊4. 张兰,刘芳,万岁桂,贾建平,李林*.阿尔茨海默病转线粒体DNA细胞模型胞质钙稳态的改变. 首都医科大学学报. 2011,32(1):67-72.核心期刊5. Lin-Lin Yin, Wei Li, Yan-Qi Chu, Lin Li*.ERK pathway activation is required for amyloid-β1-40-induced neurotoxicity of THP-1 human monocytes towards SK-N-SH neuroblastoma. Brain Research. 2011,1378:. 李雅莉、赵玲、魏海峰、李林*.开郁胶囊对抑郁动物模型的影响. 中国实验方剂学杂志. 2011,17(14):182-185.核心期刊7. 杨翠翠,李林*.中药有效成分药物代谢动力学研究. 中华中医药学刊. 2011,29(9):2006-2008.核心期刊8. 白颖,李林*.中药抗血小板作用及其机制研究进展. 中华中医药杂志. 2011,26(4):770-773.核心期刊9. Fangling Sun, Lan Zhang, Ruyi Zhang, Lin Li*..Tetrahydroxystilbene glucoside protects human neuroblastoma SH-SY5Y cells against MPP+ -induced cytotoxicity.. European Journal of Pharmacology. 2011,660:. 尹琳琳,林丽莉,李林*.淫羊藿黄酮对实验性自身免疫性脑脊髓炎大鼠模型病理特征的干预. 中国药学杂志. 2011,46(18):1412-1416.核心期刊11. 亚白柳,李林*.高脂血症与微循环功能障碍研究进展. 医学综述. 2011,17(20):3041-3043.核心期刊12. 张丽,叶翠飞,沈芊,李林*.高效液相荧光法测定大鼠脑内氨基酸类神经递质方法的改良. 中国实验动物学报. 2011,19(5):376-380.核心期刊13. Ruiqin Yao, Lan Zhang, Xiaoli Li, Lin Li*. Effects of Epimedium flavanoids on proliferation and differentiation of neural stem cells in vitro. Neurological Research. 2010,32(7):. Li-hong Zhao, Yue-xia Ding, Lan Zhang, Lin Li*.Cornel iridoid glycoside improves memory ability and promotes neuronal survival in fimbria-fornix transected rats. . European Journal of Pharmacology. 2010,647:. Yu-Jing Chen, Xiao-Bo Huang, Zong-Xin Li, Lin-Lin Yin, Wen-Qiang Chen, Lin Li *.Tenuigenin protects cultured hippocampal neurons against methylglyoxal-induced neurotoxicity. European Journal of Pharmacology. 2010,645:. 王文*,许栋明,相婕,李蕾,王培昌,艾厚喜,张丽,李林.莫诺苷对局灶性脑缺血再灌注大鼠神经元损伤的影响. 中国康复理论与实践. 2010,16(1):27-28.核心期刊17. 丁月霞, 张丽, 叶翠飞, 王文, 李 林*.山茱萸环烯醚萜苷对穹隆海马伞切断大鼠学习记忆能力和突触生长素的影响. 中国新药杂志. 2010,19(2):133-138.核心期刊18. 王文*,许栋明,相婕,李蕾,王培昌,艾厚喜,张丽,李林.莫诺苷对局灶性脑缺血再灌注大鼠神经元损伤的影响. 中国康复理论与实践. 2010,19(2):133-138.核心期刊19. 王蓉,赵志炜,张丽,张兰,李林*.参乌胶囊及其有效成分二苯乙烯苷对老年大鼠海马神经元突触体素表达的影响. 首都医科大学学报. 2010,31(1):60-64.核心期刊20. 相婕,许栋明,王文*,云彩麟*,张丽,艾厚喜,李林.局灶性脑缺血再灌注后神经发生及药物对其作用的研究进展. 中国康复理论与实践. 2010,16(2):103-105.核心期刊21. 赵玲,魏海峰,李雅莉,张丽,李林*.从血液流变学的改变分析肾上腺素致血瘀证大鼠模型的建立. 中西医结合心脑血管病杂志. 2010,8(2):188-190.核心期刊22. Bai-liu Ya, Chun-yang Li, Lan Zhang, Wen Wang, Lin Li*.Cornel iridoid glycosides inhibits inflammation and apoptosis in brain of rats with focal cerebral ischemia. Neurochemical Research. 2010,35(5):. 王娜,李林*.山茱萸环烯醚萜苷对创伤性脑损伤大鼠炎症反应的影响. 中国临床药理学与治疗学. 2010,3(15):255-259.核心期刊24. 叶翠飞,张丽,张兰,李林*.参乌胶囊对东莨菪碱模型大鼠学习记忆能力和脑内胆碱能系统的影响. 中国药学杂志. 2010,45(9):661-664.核心期刊25. 张如意,张丽,艾厚喜,叶翠飞,孙雪静,李林*.金童颗粒治疗拟抽动秽语综合征模型大鼠的药理机制研究. 中国康复理论与实践. 2010, 16(10):910-912.核心期刊26. 张如意、艾厚喜、张丽、叶翠飞、左萍萍、李林*.拟抽动秽语综合征大鼠模型的复制及再评价. 中国神经精神疾病杂志. 2010,36(9):552-554.核心期刊27. 张丽,赵宁,王蓉,李林*.参乌胶囊及其有效成分二苯乙烯苷对老年大鼠脊髓腰节段细胞凋亡调节因子及p-CREB的影响. 中国比较医学杂志. 2010,20(8):6-9.核心期刊28. 白颖,王世全,张兰,张如意,尹琳琳,张丽,李雅莉,李林*.山茱萸环烯醚萜苷对家兔、大鼠血小板聚集及出血时间的影响. 中国临床药理学与治疗学. 2010,15(12):1373-1376.核心期刊29. 王文*,孙芳玲,安宜,艾厚喜,张丽,李林.莫诺苷抑制过氧化氢诱导的SH-SY5Y神经细胞凋亡. 中国康复理论与实践. 2009,15(5):428-430.核心期刊30. 李雅莉,赵宁,张丽,李林*.大鼠脊髓腰节段神经元存活信号转导通路及凋亡调控因子的增龄变化. 中国老年学杂志. 2009,30(2):179-181.核心期刊31. 王文,孙芳玲,安宜,黄文婷,艾厚喜,张丽,李林*.莫诺苷抑制过氧化氢诱导的SH-SY5Y神经细胞钙超载和细胞毒. 中国康复理论与实践. 2009,15(3):201-202.核心期刊32. 林丽莉,宋秋洁,叶翠飞,张丽,李林*.淫羊藿黄酮对阿尔茨海默病模型神经炎性反应的影响. 中国康复理论与实践. 2009,15(2):123-125.核心期刊33. 王文,许栋明,相婕,李蕾,王培昌,艾厚喜,张丽,李林.莫诺苷对大鼠脑缺血再灌注神经凋亡的影响. 中国康复理论与实践. 2009,15(12):1101-1103.核心期刊34. Wen Wang, Fangling Sun, Yi An, Houxi Ai, Li Zhang, Wenting Huang, Lin Li*.Morroniside protects human neuroblastoma SH-SY5Y cells against hydrogen peroxide-induced cytotoxicity. European Journal of Pharmacology. European Journal of Pharmacology. 2009,613:. 王蓉,唐玉,张丽,赵志炜,张兰,李林*.大鼠海马神经元突触超微结构的增龄变化. 中国比较医学杂志. 2009,19(4):18-22.核心期刊36. Ruiqin Yao, Lan Zhang, Xiaoli Li, Lin Li*.Effects of Epimedium flavanoids on proliferation and differentiation of neural stem cells in vitro. Neurol Res. 2009,Epub:【未填写起止页码】.SCI37. Ruiqin Yao, Lan Zhang, Wen Wang, Lin Li*.Cornel Iridoid Glycoside Promotes Neurogenesis and Angiogenesis and Improves Neurological Function after Stroke in Rats. Brain Research Bulletin. 2009,79(1):. 杨潘,宋秋洁,王月华,杜冠华,李林*.淫羊藿黄酮对APP695基因转染神经细胞β-淀粉样肽及β-分泌酶的影响. 中国康复理论与实践. 2009,15(2):126-128.核心期刊39. Wen Wang, Fangling Sun, Yi An, Houxi Ai, Li Zhang, Wenting Huang, Lin Li*.Morroniside protects human neuroblastoma SH-SY5Y cells against hydrogen peroxide-induced cytotoxicity. European Journal of Pharmacology. 2009, 613 :. 刘丽,李林*,赵玲,张丽,李雅莉,叶翠飞.二苯乙烯苷对慢性脑缺血大鼠学习记忆的影响. 中国药理学与毒理学杂志. 2008,22(2):. 赵玲,李春阳,张丽,崔巍,张兰,李林*.二苯乙烯苷对局灶性脑缺血大鼠脑组织细胞凋亡的影响. 中草药. 2008,39(3):. 赵玲,李林*,魏海峰,张丽,李雅莉,.痰瘀阻窍证高脂血症大鼠学习记忆能力的动态变化. 中西医结合心脑血管病杂志. 2008,6(4):. 刘莹,李林,杨慧,李雅莉,张兰.二苯乙烯苷对过度表达-synuclein蛋白的转基因COS-7细胞株的影响. 中国康复理论与实践. 2008,14(4):. 魏海峰,亚白柳,赵玲,叶翠飞,张丽,李林*.急性脑缺血大鼠模型血瘀证舌象表现的评价方法及其与血液流变学的关系. 中西医结合学报. 2008,6(1):. Wen Wang,Wenting Huang,Lin Li*,Houxi Ai,Fangling Sun,Ci Liu,Yi Prevents Peroxide-induced Apoptosis by Induction of Endogenous Glutathione in Human Neuroblastoma Cells. Cell Mol Neurobiol. 2008,28:. 黄文婷,王文,艾厚喜,安宜,李林*,王玉兰.莫诺苷对SH-SY5Y神经细胞生长的影响及对过氧化氢诱导损伤的保护。. 中国康复理论与实践. 2007,13(9): . 王文,田丰,艾厚喜,胥云,李林*.HPLC测定泰思胶囊中二苯乙烯苷的含量. 中国新药杂志. 2007,16(2):. 魏海峰,叶翠飞,吴燕川,王玉兰,丁月霞,赵宁,李林*.安神补脑液对睡眠剥夺大鼠脑内诱导型一氧化氮合酶及褪黑素的影响. 中药新药与临床药理. 2007,18(5):. 亚白柳,魏海峰,赵玲,叶翠飞,张丽,李林*.从高脂饮食家兔血脂和血液流变学的动态变化探讨中医痰瘀相关的生物学基础. 中西医结合心脑血管病杂志. 2007,5(10):. 赵玲,张兰,李雅莉,张丽,李林*.5-羟甲基糠醛对脑缺血再灌小鼠学习记忆功能及脑组织自由基代谢的影响. 中国药房. 2007,18(13):. 李玮, 李林*, 褚燕琦, 李雅莉, 索爱琴, 张健.β-淀粉样肽诱导单核细胞培养上清液致神经细胞损伤模型的建立. 中国神经免疫学和神经病学杂志. 2007,14(3):121-123, . 李玮, 李林*, 褚燕琦, 张兰, 李雅莉.人参皂苷对Aβ诱导单核细胞培养上清液致神经细胞损伤的影响. 中国药学杂志. 2007,42(21):. 张兰,于顺,邢颖,叶翠飞,陈彪,李林*.APP转基因拟痴呆小鼠模型脑内-synuclein 的增龄改变. 中国病理生理学杂志. 2007,23(12):. 张兰,李林,安文林,薛冰.山茱萸拮抗线粒体缺陷致神经细胞微管及微管相关蛋白表达异常. 中国药理学通报. 2007,23(3):. 艾厚喜,黄文婷,王文,安宜,李林.莫诺苷抑制过氧化氢诱导的SH-SY5Y神经细胞氧化损伤. 中国康复理论与实践. 2007,13(11):. Rong Wang, Yu Tang, Bo Feng, Lan Zhang, Lin Li*. .Changes in hippocampal synapses and learning-memory ability in age-increasing rats and effects of Tetrahydroxy-stilbene glucoside in aged rats. Neuroscience. 2007,149:. 张丽,李春阳,赵玲,张兰,李林*.山茱萸环烯醚萜苷对局灶性脑缺血模型大鼠神经功能和神经损伤的影响. 中国康复理论与实践. 2007,13(3):. 李春阳,李林*,魏海峰,张兰,赵玲.局灶性脑缺血大鼠模型血瘀证相关指标和脑损伤病理生理的动态变化. 中国中西医结合急救杂志. 2007,14(5):. 李雅莉,赵玲,张兰,李林.二苯乙烯苷对缺糖缺氧致海马神经元凋亡的影响. 中国新药杂志. 2007,16(20):. 张如意,王蓉,叶翠飞,赵玲,李春阳,李林*.参乌胶囊对大鼠皮肤老化的影响. 中国老年学杂志. 2007,27(20):. 姚瑞芹,李林*。.血管内皮细胞生长因子在缺血性脑损伤中的血管新生、神经发生和神经保护作用. 中国康复理论与实践. 2007,13(3):208-211.
单纯的喝咖啡是不能够预防老年痴呆的,预防老年痴呆首先就是要控制好患者避免出现脑血管疾病。因为长期的高血压,糖尿病,或者是动脉粥样硬化,很有可能会到颅内出血或者是脑梗的发生,一旦出现了脑血管疾病,就是非常容易导致患者出现老年痴呆的。要想预防老年痴呆,可以从以下几个方面入手:一,定期做体检,老年痴呆发病常很隐匿,因此正确认识痴呆早期的症状,定期去医院做检查,使病人得到及时的治疗,就显得非常重要。二,合理膳食,三餐规律,多吃一些富含微量元素、维生素和矿物质等有益大脑的食物。三餐要有规律,合理搭配,每餐要少吃、吃好,保持大便的通畅。三,要勤动脑,老年人应积极的培养学习兴趣,参加脑力劳动,活跃脑细胞,以防病抗衰老。四,保持心情愉快。身心抑郁的人容易引发老年痴呆症,因此要保持身心的豁达、乐观向上,才能健康永在。五,适当的体力及脑力锻炼,也可以有效地预防老年痴呆,如每天早晨及傍晚在空气清新的地方快走一小时。快步走可以提高摄氧量,有刺激脑细胞,防止脑细胞退化。
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