Manipulator is often used in the field of industrial automation to automatically capture an operation of the device, and more for the automatic production line, automatic machine loading and unloading, CNC equipment, automatic tool changing device. As the pneumatic technology is compressed air as the medium to gas source for the power of the energy transfer technology, operational reliability, long life, no pollution to environment, so the manipulator drive system are often used in pneumatic technology. Pneumatic robot as a manipulator, it has a simple structure, light weight, fast, stable, reliable, energy-saving advantages and do not pollute the environment has been widely used. Therefore, pneumatic manipulator has important practical value. This is a KNT-P301 Pneumatic Manipulator Training Equipment for the study, using PLC to control the operation of pneumatic manipulator. This paper studies the pneumatic manipulator based on PLC control system. Finally, PLC software programming flow chart for the end of the line hardware and software debugging.