Objective: To observe the esophagus drainage LMA anesthesia for gynecological hysterectomy clinical effect. Research laryngeal mask and tracheal intubation for patients cortisol (Cortisol, COR) and ACTH (Adrenocorticotropic Hormone, ACTH) impact. Compare LMA under general anesthesia and tracheal intubation for the size of the human stress response. Research Methods: Gynecologic under anesthesia hysterectomy 30 patients, ASA grade I-II-class, aged 35-60 years old, weight 45-75kg. All patients undergoing surgery were randomly divided into LMA group (L group, n = 15) and tracheal intubation group (T group, n = 15). Calm after admission in patients with 5 min, and opening up two intravenous access, an arm vein for the transfusion medicine, another elbow vein for blood samples from time to of anesthesia in all cases are used midazolam , fentanyl 3μg/kg, propofol , vecuronium intravenous injection, esophageal and laryngeal mask type drainage catheter into the trachea are placed in a one-time success. Narcotic maintenance of propofol pump 6mg/kg/h, inhalation of 1% -3% isoflurane, during operation in accordance with the depth of anesthesia and muscle relaxation circumstances additional intermittent fentanyl and vecuronium. Observation intubation (cover) before intubation immediately after intubation 1min, 5min, 10min, time period, mean arterial pressure (MAP), heart rate (HR), end-tidal carbon dioxide partial pressure (PETCO2), peak airway pressure (Ppeak).Laryngeal mask airway under general anesthesia with endotracheal intubation ventilation Comparison of stress response and found that before and after the laryngeal mask tube and the tracheal intubation group blood pressure, heart rate, end-tidal carbon dioxide partial pressure changes, compare the two groups of patients with cortisol, ACTH and other stress indicators. LMA group confirmed the group would be able to reduce the intubation tube in patients after the hormone cortisol and ACTH response to the impact of : The comparison group, L group before and after LMA insertion rate (HR), mean arterial pressure (MAP), cortisol (COR), adrenocorticotropic hormone (ACTH) compared to T0 time did not change significantly, no significant difference (P> ), T group before and after tracheal intubation COR, ACTH at T3, T4 was significantly higher than the record time T0 values (P <). Group compared to group L and T groups T3 and T4 in the time period (P <) differences statistically. Conclusion: 1, laryngeal mask airway tracheal intubation more traditional, when the stress response in patients with small. 2, laryngeal mask airway in the perioperative hemodynamic stability. 3, laryngeal mask airway after tracheal intubation than the restoration of stable, less secretion. Keywords: tracheal intubation, laryngeal mask esophageal drainage, hysterectomy, cortisol, adrenocorticotropic hormone