翻译完了,好多医学专业的词,我承认我也用翻译机了 我重新编辑了下格式: Abstract Background: Breast cancer is the first cause of cancer death among women and its incidence doubled in the last two decades. Several approaches for the treatment of these cancers have been developed. The axillary lymph node dissection (ALND) leads to numerous morbidity complications and is now advantageously replaced by the dissection and the biopsy of the sentinel lymph node. Although this approach has strong advantages, it has its own limitations which are manipulation of radioactive products and possible anaphylactic reactions to the dye. As recently proposed, these limitations could in principle be by-passed if semiconductor nanoparticles (quantum dots or QDs) were used as fluorescent contrast agents for the in vivo imaging of SLN. QDs are fluorescent nanoparticles with unique optical properties like strong resistance to photobleaching, size dependent emission wavelength, large molar extinction coefficient, and good quantum yield. Methods: CdSe/ZnS core/shell QDs emitting around 655 nm were used in our studies. 20 μL of 1 μM (20 pmol) QDs solution were injected subcutaneously in the anterior paw of healthy nude mice and the axillary lymph node (ALN) was identified visually after injection of a blue dye. In vivo fluorescence spectroscopy was performed on ALN before the mice were sacrificed at 5, 15, 30, 60 min and 24 h after QDs injection. ALN and all other organs were removed, cryosectioned and observed in fluorescence microscopy. The organs were then chemically made soluble to extract QDs. Plasmatic, urinary and fecal fluorescence levels were measured. Results: QDs were detected in ALN as soon as 5 min and up to 24 h after the injection. The maximum amount of QDs in the ALN was detected 60 min after the injection and corresponds to of the injected dose. Most of the injected QDs remained at the injection site. No QDs were 摘要: 背景:在过去20年乳腺癌是引起女性死亡数量双倍上升的首要因素。有几个可以接近治愈癌症的方法呗研制出来。ALND(具体的太专业,不会翻译)被解剖和哨淋巴腺节点取代。虽然这个方法有很强的优势,但在处理放射性物质和对燃料(等化学物品)引起的过敏反应上也有他的局限性。最近有报道指出,这些限制原则上可绕过如果半导体纳米粒子(量子点或量子点)被用作荧光造影剂的体内成像的前哨淋巴结。量子点的荧光纳米粒子具有独特的光学性质一样抗性强漂白,大小取决于发射波长,摩尔消光系数大,和良好的量子产率。 方法::硒化镉/硫化锌核/壳量子点发光波长在655中使用了我们的研究。 20 μL的1微米( 20 pmol )量子点溶液皮下注射前爪子在裸鼠体内的健康和腋窝淋巴结(阿仑膦酸钠)被确定视觉注射后的蓝染料。活体荧光光谱进行的阿仑膦酸钠在小鼠处死5 , 15 , 30 , 60分钟和后24 h量子点注射。AlN和所有其他机关被拆除, cryosectioned和荧光显微镜观察到。然后作出可溶性化学提取量子点。血浆,尿和粪便荧光水平的变。 结论:量子点检测阿仑膦酸钠尽快5分钟至24小时后注射。最高金额的量子点中的阿仑膦酸钠发现60分钟后,注射相当于 %的注射剂量。大多数注入量子点仍然在注射部位。没有量子点.