有毒的少女
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至今 中国药科大学化学生物学研究室主任、特聘教授、博导 美国百时美施贵宝（Bristol-Myers Squibb）药物研究院任研究员、高级研究员 美国MicroGenomics, Inc.任研究员 美国加州大学圣地亚哥分校(University of California, San Diego)Edward A. Dennis教授实验室NIH博士后 美国衣阿华大学（University of Iowa）生物催化中心David T. Gibson院士实验室博士后 美国德州农工大学 ( Texas A & M University) George . Chiou教授实验室访问学者 江苏省苏州市水产研究所任助理工程师、工程师教育背景— 美国衣阿华大学（University of Iowa）药学院药物及天然产物化学专业（导师：John P. N. Rosazza教授） 博士学位— 中国药科大学药学专业 学士学位目前承担项目1. 教育部、国家外国专家局高等学校学科创新引智计划项目（“111”计划）负责人：药物生物合成和生物转化的创新引智基地（2008年－2012年，No. 111-2-07）2. 教育部科学技术研究重点项目负责人：作为高效生物催化剂的全新双羰基还原酶的分子结构改造（2008年－2009年，）学术论文34. Ji, Z., Mei, ., Lory, ., Gilbertson, ., Chen, .* & Cheng, . Chemical genetic screening of synthetic lethal pancreatic cancer inhibitors using a KRAS-based human pancreatic cancer cell model. Front. Biosci. 2008 In . Wu, ., Liu, N. & Chen, .* A bacterial enzyme catalyzing double reduction of a β,δ-diketo ester with unprecedented stereoselectivity. Nature Proceedings, 2008, hdl:10101/. Hanson, ., Davis, ., Chen, ., Goldberg, ., Parker, ., Tully, ., Montana, . & Patel, . Preparation of R-amines from racemic amines with an S-amine transaminase from Bacillus megaterium. Adv. Synth. Catal. 2008, 350(9), . Liu, ., Yu, ., Chen, .* Determination of enantiomeric excess of ethyl 3,5-dihydroxy-6-benzyloxy hexanoate by chiral reverse phase high performance liquid chromatography. Chirality, 2008, 20(1), . 陈依军*, 吴旭日. 生物催化与新药研发, 化学进展, 2007, 19 (12), 1947-1954.（特约综述）29. Liu, ., Chen, ., Yu, . & Chen, * A novel ketone derivative of artemisinin biotransformed by Streptomyces griseus ATCC 13273. Bioorg. Med. Chem. Lett. 2006, 16 (21), . Guo, ., Chen, ., Goswani, A., Hanson, R. H. & Patel, . Synthesis of ethyl and t-butyl(3R,5S)-dihydroxy-6-benzyloxy hexanoates via diastereo- and enantioselective microbial reduction. Tetrahedron: Asymmetry 2006, 17(8), . Steele, ., Chen, ., Dougherty, ., Li, W., Hofstead, S., Lam, K., Xing, Z. & Chiang, . Purification, functional cloning and characterization of phenylalanine aminomutase: first committed step in Taxol biosynthesis. Arch. Biochem. Biophys. 2005, 438 (1), . Reguerio-Ren, A., Carroll, ., Chen, ., Matson, ., Huang, S, Mazzucco, ., Stickle, ., Vyas, ., & Balasubramanian, . Core-modified sordaricin derivatives: Synthesis and antifungal activity. Bioorg. Med. Chem. Lett. 2002, 12 (23), . Serrano-Wu, M, St Laurent. D., Chen, ., Huang, S, Lam, ., Matson, ., Huang, S, Mazzucco, ., Stickle, ., Tully, T., Wong, H., Vyas, ., & Balasubramanian, . Sordarin oxazeoine derivatives as potent antifungal agents. Bioorg. Med. Chem. Lett. 2002, 12 (19), . Canne, ., Botti, P., Simon, ., Chen, ., Dennis, ., & Kent, . Chemical protein synthesis by solid phase ligation of unprotected peptide segments J. Am. Chem. Soc. 1999, 121 (38), . Yang, ., Mosior, M., Johnson, C., Chen, ., & Dennis, . Group-specific assays that distinguish between the four major types of phospholipase A2. Anal. Biochem. 1999, 269 (2), . Chen, ., & Dennis, . Expression and characterization of human group V phospholipase A2. Biochim. Biophys. Acta. 1998, 1349 (1), . Chen, ., Rosazza, ., Reese, ., Chang, ., Nowakowski, ., & Kiplinger, . Microbial models for soil metabolism: Microbial transformations of danofloxacin. J. Ind. Microbiol. Biotechnol. 1997, 19 (5-6), . Chen, ., & Rosazza, . Oligopeptides as substrates and inhibitors for a new constitutive nitric oxide synthase from rat cerebellum. Biochem. Biophys. Res. Commun. 1996, 224 (2), . Chen, ., & Rosazza, . Purification and characterization of nitric oxide synthase (NOSNoc) from Nocardia species. J. Bacteriol. 1995, 177 (17), . Chen, ., & Rosazza, . Microbial transformation of ibuprofen by a Nocardia species. Appl. Environ. Microbiol. 1994, 60 (4), . Chen, ., & Rosazza, . A bacterial nitric oxide synthase from Nocardia species. Biochem. Biophys. Res. Commun. 1994, 203 (2), . Chiou, . & Chen, . Effects of antiglaucoma drugs on ocular flow in ocular hypertensive rabbits. J. Ocular. Pharmacol. 1993, 9, . Chiou, . & Chen, . Improvement of ocular blood-flow with dopamine antagonists on ocular hypertensive rabbit eyes. Acta. Pharmacologica Sinica, 1992, 13 (6), . Chiou, . & Chen, . Effects of dopamine agonist bromocriptine and some dopamine antagonists on ocular flow. J. Ocular. Pharmacol. 1992, 8 (4), . Chiou, . & Chen, . Effects of D- and L-isomers of timolol on retinal and choroidal blood flow in ocular hypertensive rabbit eyes. J. Ocular Pharmacol. 1992, 8 (3), . Chiou, ., Shen, ., Zheng, . & Chen, . Enhancement of systemic delivery of peptide drugs via ocular route with surfactants. Drug Develop. Res. 1992, 27 (2), . 陈依军, 金冬梅. 测定珍珠粉总卟啉成分的荧光光谱法. 水产学报. 1990, 14 (2), . 陈依军, 夏尔宁, 王淑如, 陈琼华. 黑木耳、银耳及银耳孢子多糖延缓衰老作用. 现代应用药学. 1989, 6 (2), . 陈依军, 谭唯杰, 卞全玲, 钱曾年. 珍珠“康乐寿”口服液抗衰老作用研究. 中国药学杂志. 1989, 24 (7), . 陈依军, 胡天喜, 陈秀武. 化学发光分析法研究珍珠卟啉类化合物抗自由基的作用. 老年学杂志. 1988, 8 (2), . 陈依军, 谭唯杰, 钱曾年, 顾振纶, 潘建新, 庄杏梅. 珍珠粉抗衰老作用的实验研究. 老年学杂志. 1988, 8 (2), . 钱曾年, 顾振纶, 王恩泽, 陈依军, 胡思初, 陈秀兰, 施家立. 健延龄延缓衰老作用的药理学研究. 中草药. 1988, 10 (7), . 陈依军, 谭唯杰, 徐黻本. 珍珠明目液对实验性白内障药效观察. 眼科通讯. 1987, 6, . 陈依军. 珍珠明目液对实验性青光眼作用的研究. 眼科通讯. 1987, 6, . 钱曾年, 顾振纶, 陈依军, 王恩泽, 庄杏梅, 朱路佳, 钱学射. 二仙春回胶囊的药理学研究.中成药研究, 1986, 11, . 钱曾年, 陈依军, 顾振纶, 庄杏梅. 二仙春回胶囊的抗衰老活性和毒性研究. 苏州医学院学报1986, 6(1), . 李耐三, 郝晓勇, 陈依军. 降眼内压药消旋噻吗心安的药理研究. 南京药学院学报. 1984, 15 (2), 40-44.非学术性文章Chen, . & Liu, N. Olympics may have a negative impact on China’s research. Nature, 2008, 454, 1049.申请和已授权专利1. Patel, ., Chen, ., Goldberg, ., Hanson, ., Gill, I., Goswami, A., Tully, T. and Parker, W. Enzymatic preparation of S-amino acid from R,S-amino acid or keto acid. WO 2007/112299A2, US 2007/0231858A1 (2007)2. Patel, ., Chu, L., Johnston, ., Guo, ., Chen, ., Goldberg, ., Hanson, ., Goswami, A. and Katipally, K. Stereoselective reduction process for the preparation of pyrrolotriazine compounds. WO 2006/130657A2 (2006), US 7,393,667 B2 (2008)3. Rosazza, . and Chen, . Purifed nitric oxide synthase. US 6,988,446B2 (2006)4. Steele, ., Chen, ., Dougherty, ., Hofstead, S., Lam, K., Li, W. and Xing, Z. Compositions and methods for altering biosynthesis of taxanes and taxane-related compounds. WO 2003066871A2 (2003), US 7,273,755B2 (2007)5. Rosazza, . and Chen, . Bacterial nitric oxide synthase. US 5,759,835 (1998).6. Rosazza, . and Chen, . Purified nitric oxide synthase from rat brain. US 5,856,158 (1998).7. 陈依军. 2－苯氧基嘧啶衍生物及其治疗用途. 中国专利号 (已授权)8. 陈依军, 石雷. 二氢吡啶酮类衍生物及其用途. 中国专利申请号. 陈依军 用于减轻或消除鼾声的口腔喷雾剂及其制备方法. 中国专利号 (已授权)10. 陈依军 一种双羰基还原酶、其基因及其应用. 中国专利申请号学术会议及交流 第十二届亚太化工联盟大会生物技术专场（大连）邀请报告，获大会最佳学术报告奖 第二届全国跨学科蛋白质研究学术讨论会（烟台）专题报告 第三届国际生物能源与生物过程工程国际会议（上海）专题报告 暨南大学生命科学学院“名家系列学术讲座”（广州） 第六届中国酶工程学术研讨会（昆明）特邀大会报告2007. 8 第五届全国化学生物学学术研讨会（昆明）邀请报告2007. 5 首届伯克利-中国健康促进中心国际高峰会议（上海）主题演讲 第五届世界华人药物化学研讨会（南京）邀请报告 第21届燃料及化学生物技术论坛（美国科罗拉多）专题报告 美国微生物学会全国年会（美国华盛顿）大会报告获奖和荣誉1．1987 江苏省苏州市科技进步奖2．1994-1996 美国衣阿华大学生物催化中心优秀博士生奖学金 入选中国科学院首批“百人计划”特聘教授4．1997-1998 美国国立卫生研究院（NIH/NCI）博士后奖学金
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