Contraction of blood vessels material local anesthesia the influence of the timeGuiyang medical school level 09 class A clinical (guiyang 550002)HuQuan MaoLiYing have GuYa YangLuQian QinYuHui YangSong QuCheng lilin ROM HeYuYang HanYan【 abstract 】Objective: to explore the experimental observation of shrinking or blood vessels to drugs without influence function time game anesthetic. Methods: the pain has a normal reflected kunming adult experimental mice randomized Numbers, the corresponding no mouse tail intravenous corresponding respectively of the concentration of the physiological saline, adrenaline, norepinephrine, phenol, the next, immediately hip subcutaneous injection at optimum lu, observation records of mice pain reflex disappear and recovery time, comparing the drug to general anesthesia lu pronounced the extension of time and shorten the role. Results: the adrenaline, norepinephrine, pheneolamine robust to general anesthesia and function of optimum time group compared to the physiological saline, respectively is extended, extend, shortened, and the adrenaline role than norepinephrine ?【 key words 】 local anesthesia adrenaline norepinephrine pheneolamine general lu pronounced