Hepatocellular carcinoma (HCC) is a serious hazard to human health, but also worldwide, one of the most common malignant tumor. HBV infection caused by a large number of studies have shown that the proportion of hepatocellular carcinoma hepatocellular carcinoma is the world number about 75 to 85%, but the specific HBV causes liver cancer has not been fully elucidated the mechanism [1]. Recent studies of hepatitis B virus genotypes, and various genotypes of the mechanism of HBV induced liver cancer has become a hot research. Domestic and international research shows that, HBV genotype may be associated with disease progression after infection clinical presentation, prognosis and treatment response and other anti-virus are closely related. Now widely recognized that genotype C caused by inflammatory necrosis and fibrosis is more severe than type B, and C-related liver cirrhosis and liver cancer; genotype B, the cumulative survival rate was significantly higher than C-. Recent studies show that, HBV DNA mutation rate than other about 10 times, HBV gene variation and clinical outcome of disease associated variant can lead to increased pathogenicity and replication, an important change in the host immune response against the epitopes and the generation HIV drug resistance. HBV gene encoding the overlapping of different, such as promoter and enhancer regulatory sequences and is located within the gene encoding, a part of the gene mutation will affect the expression of multiple genes to form HBV gene mutation [2,3], so more complete study of hepatitis B virus genome variability and its biological significance is particularly important. HBV genotype on the domestic and foreign scholars in recent years, the variation between sites and the HCC study done a lot in recent years, Yunnan has on the distribution of HBV genotypes reported, but on the HBV genotype and HCC variation between sites not been reported yet. This study aimed to chronic HBV infection in Yunnan genotype infection to understand the detection of variable sites, to explore the genotype of chronic HBV infection, common variable sites and the relationship between hepatocellular carcinoma.翻译整段还真不简单。。。。。