In science and technology is highly developed today, economic globalization makes with regional features of culture gradually disappear. This paper introduces the concepts of the regional culture from China, analysis, and hotel indoor set with regional culture in the modern research of applied research design, the hotel, the case of comparison and thinking, summarizes the research and design gimmick, discusses the application of regional culture in the hotel the significance and historical inevitability. And through the analysis of the specific case to explore "time spirit" and "regional culture" dialectical unity feasible concrete principle and method. Think of new era "regional culture" is not a simple "reminiscence" and "returning to the traditional", but the spirit of the era, is the innovation.