Objective: Biochemical pellets plus five original form for five additional biochemical capsule, the original form of the system of law for the Chinese angelica, peach kernel, ginger, licorice mixed aqueous extract made five additional biochemical, powder and add Chuanxiong Health Ciwujia extract fully mixed decompression drying, grinding, filling, which exist for the problem to get five plus biochemical decompression dry extract part of a long time and a long drying time and easy to lead to the active ingredient of ferulic acid decomposition, preparation process of powder fluidity bad, bad stability capsule easy moisture absorption, to the production and storage difficult. In this paper, the effective extraction and purification of the basic site up and optimize the extraction of part of process, clear Ciwujia extract extraction method to improve the five plus the dry extract biochemical methods were prepared using extrusion-spheronization five Canadian Health of pellets, liquid filling process to resolve bad, easy to extract powder moisture absorption issues, carried out simultaneously pellets prescription design, the stability of research and study the safety and efficacy research. Re-filled capsules made of pellets, that is, improved mobility, increased the stability of formulations. Methods: The orthogonal design experiment to determine the Ciwujia Ciwujia made mention medicinal extract powder technology, employs advanced spray-drying method of replacing the five plus extract biochemical decompression drying method, the use of advanced Extrusion - spheronization technology, filling plus excipients microcrystalline cellulose, ethanol and water mixture for the adhesive to produce pellets. At the same time, the prescription inspection of the powder pellets study the nature, yield and in vitro dissolution rate measured in Ciwujia pellets (according to isofraxidin dollars) content. Results: The identified Ciwujia extract reasonable extraction process, through the study of biochemical extract powder plus five differential indicators to determine the five plus biochemical extract spray drying feasible way to Microcrystalline Cellulose for accessories, ethanol and water mixture for the adhesive part of the preparation process, the pellets obtained roundness is not only good, but also improved the flow of powder capsule filling, and determine extrusion speed 120r/min, spheronization speed 50r/min, spheronization time process conditions for 10min, the roundness of pellets, liquid, dissolution are better. Conclusion: The use of extrusion-spheronization granulator five additional biochemical mechanism for pellets prepared by the process is feasible, simple technology, quality and stability. Key words: five pellets plus biochemical study of quality standards Thesis completed Location: a lot of Pharmaceutical R & D centers, more Pharmaceutical solid dosage forms workshop