1. Fan HY, Liu Z, Mullany LK, Richards JS.Consequences of RAS and MAPK activation in the ovary: The good, the bad and the ugly.Mol Cell Endocrinol. 2012 ,356:74-792. Richards JS,Fan HY, Liu Z, Tsoi M, Laguë MN, Boyer A, Boerboom D.Either Kras activation or Pten loss similarly enhance the dominant-stable CTNNB1-induced genetic program to promote granulosa cell tumor development in the ovary and testis.Oncogene.2011,1–17 【PDF download 】3. Mullany LK,Fan HY, Liu Z, White LD, Marshall A, Gunaratne P, Anderson ML, Creighton CJ, Xin L, Deavers M, Wong KK, Richards JS.Molecular and functional characteristics of ovarian surface epithelial cells transformed by KrasG12D and loss of Pten in a mouse model in vivo.Oncogene2011, 30:3522–3536 【PDF download 】4. Fan HY, Liu Z, Johnson PF, Richards JS.CCAAT/Enhancer binding proteins (C/EBP)-α and -β are essential for ovulation, luteinization and the expression of key target genes.Molecular Endocrinology, 2011, 25(2): 253-268 【PDF download 】5. Noma N, Kawashima I,Fan HY, Fujita Y, Kawai T, Tomoda Y, Mihara T, Richards JS, and Shimada M.LH-induced neuregulin 1 (NRG1) type III transcripts control granulosa cell differentiation and oocyte maturation.Molecular Endocrinology, 2011 (1):104-166. Fan HY, O’connor A, Shitanaka M, Shimada M, Liu Z, Richards JS.Beta-catenin (CTNNB1) promotes preovulatory follicular development but represses luteinizing hormone-mediated ovulation and luteinization.Molecular Endocrinology, 2010, 24(8):1529-15427. Fan HY. BubR1, a spindle assembly checkpoint protein in mammalian oocyte meiosis.Cell Cycle. 2010, 9(8):1458 【PDFDownload】8. Liu Z,Fan HY, Wang Y, Richards JS. Targeted disruption of MAPK14 (p38MAPK alpha) in granulosa cells and cumulus cells causes cell specific and compensatory changes in gene expression profiles that maintain fertility in vivo.Molecular Endocrinology, 2010 24(9):1794-8049. Fan HY, Richards JS. Physiological and pathological actions of RAS in the ovary.Molecular Endocrinology, 2010,24:286-298 【PDF download 】10. Fan HY, Liu Z, Paquet M, Wang J, Lydon JP, DeMayo FJ, Richards JS. Cell type-specific targeted mutations of Kras and Pten document proliferation arrest in granulosa cells versus oncogenic insult to ovarian surface epithelial cells.Cancer Research, 2009, 69:6463-6472 【PDF download 】11. Fan HY,Liu Z, Shimada M, Sterneck E, Johnson PF, Hedrick SM, Richards JS. MAPK3/1 (ERK1/2) in ovarian granulosa cells are essential for female fertility.Science, 2009, 324:938-941. (Comment in:Science, 2009, 324:938-941.New England Journal of Medicine, 2009, 361:718-719) 【PDF download】12. Sun Y, Kucej M,Fan HY, Yu H, Sun QY, Zou H. Separase is recruited to mitotic chromosomes to dissolve sister chromatid cohesion in a DNA-dependent manner.Cell, 2009, 137:123-132. 13. Liu Z, de Matos DG,Fan HY, Shimada M, Palmer S, Richards JS.(2009). Interleukin-6: an autocrine regulator of the mouse cumulus cell-oocyte complex expansion process.Endocrinology150(7): 3360-8. 【PDF download】14. Liu Z, Rudd MD, Hernandez-Gonzalez I, Gonzalez-Robayna I,Fan HY, Zeleznik AJ, Richards JS.FSH and FOXO1 regulate genes in the sterol/steroid and lipid biosynthetic pathways in granulosa cells.Molecular Endocrinology, 2009 23:649-661. 【PDF download】15. Laguë MN, Paquet M,Fan HY, Kaartinen MJ, Chu S, Jamin SP, Behringer RR, Fuller PJ, Mitchell A, Doré M, Huneault LM, Richards JS, Boerboom D. Synergistic effects of Pten loss and WNT/CTNNB1 signaling pathway activation in ovarian granulosa cell tumor development and progression.Carcinogenesis, 2008, 29(11):2062-2072. 【PDF download 】16. Fan HY, Liu Z, Cahill N, Richards JS. Targeted disruption of Pten in ovarian granulosa cells enhances ovulation and extends the life span of luteal cells.Molecular Endocrinology, 2008, 22(9):2128-2140. (Comment in Nature Medicine, 2008, 11:1192-1193.) 【PDF download 】17. Fan HY, Shimada M, Liu Z, Cahill N, Noma N, Wu Y, Gossen J, Richards JS. Selective expression of KrasG12D in granulosa cells of the mouse ovary causes defects in follicle development and ovulation.Development, 2008, 135:2127-2137. 18. Wayne CW,Fan HY,Cheng X, and Richards JS. FSH-induces multiple signaling cascades: evidence that activation of SRC, RAS and the EGF receptor are critical for granulosa cell differentiation.Molecular Endocrinology, 2007, 21:1940-1957. 【PDF download 】19. Fan HY, Sun QY, Zou H. Regulation of separase in meiosis: separase is activated at the metaphase I-II transition in Xenopus oocytes during meiosis.Cell Cycle, 2006, 10:198-204 20. Fan HY, Huo LJ, Schatten H, Chen DY, Sun QY. Protein kinase C and MAPK cascade in mouse cumulus cells: crosstalk and effect on meiotic resumption of oocyte.Biology of Reproduction, 2004, 70:1178-1187 【PDF download 】21. Fan HY, Sun QY. Involvement of mitogen-activated protein kinase Cascade during oocyte maturation and fertilization in mammals.Biology of Reproduction, 2004, 70(3):535-547 【PDF download 】22. Fan HY, Tong C, Teng CB, Lian L, Li SW, Yang ZM, Chen DY, Schatten H, Sun QY. Characterization of Polo-like kinase-1 in rat oocytes and early embryos implies it’s functional roles in the regulation of meiotic maturation and cleavage.Molecular Reproduction and Development, 2003 65:318-32923. Fan HY, Huo LJ, Meng XQ, Zhong ZS, Hou Y, Chen DY, Sun QY. Involvement of calcium/calmodulin-dependent protein kinase II (CaMKII) in the meiotic maturation and activation of pig oocytes.Biology of Reproduction, 2003,69:1552-1564 【PDF download 】24. Fan HY, Tong C, Lian L, Li SW, Gao WX, Cheng Y, Chen DY, Schatten H, Sun QY. Characterization of ribosomal S6 protein kinase p90rsk during meiotic maturation and fertilization in pig oocytes: MAPK-associated activation and localization.Biology of Reproduction, 2003, 68:968-977 【PDF download 】25. Tong C,Fan HY, Lian L, Li SW, Chen DY, Schatten H, Sun QY. Polo-like kinase 1 is a pivotal regulator of micrutubule assembly during mouse oocyte meiotic maturation, fertilization, and early embryonic mitosis.Biology of Reproduction, 2002, 67:546-554 【PDF download 】26. Fan HY, Li MY, Tong C, Chen DY, Xia GL, Song XF, Schatten H, Sun QY. Inhibitory effects of cAMP and protein kinase C on meiotic maturation and MAP kinase phosphorylation in porcine oocytes.Molecular Reproduction and Development, 2002, 63: 480-487 27. Fan HY, Tong C, Li MY, Lian L, Chen DY, Schatten H, Sun QY. Translocation of classical protein kinase C (cPKC) isoforms in porcine oocytes: implications of PKC involvement in the regulation of nuclear activity and cortical granule exocytosis.Experimental Cell Research, 2002, 277:183-191 28. Liang CG, Su YQ,Fan HY, Schatten H and Sun QY. Mechanisms regulating oocyte meiotic resumption: roles of mitogen-activated protein kinase.Molecular Endocrinology, 2007, 21, 2037-205529. Tong C,Fan HY, Li SW, Chen DY, Schatten H, Song XF, Sun QY. Effects of MEK inhibitor U0126 on meiotic progression in mouse oocyte: microtuble organization, asymmetric division and metaphase II arrest.Cell Research, 2003, 13:375~38330. Huo LJ,Fan HY, Zhong ZS, Schatten H, Chen DY, Sun QY. Involvement of ubiquitin-proteasome pathway in mouse oocyte meiotic maturation, fertilization and early embryonic cleavage.Mechanisms of Development, 2004 121(10):1275-128731. Huo LJ,Fan HY, Liang CG, Yu LZ, Zhong ZS, Schatten H, Chen DY, Sun QY. Regulation of ubiquitin-proteasome pathway on pig oocyte meiotic maturation and fertilization.Biology of Reproduction, 2004, 71(3):853-86232. Cheng Y,Fan HY, Wen DC, Tong C, Zhu ZY, Lei L, Sun QY, Chen DY. Asynchronous cytoplast and karyoplast transplantation reveals that the cytoplasm determines the developmental fate of the nucleus in mouse oocytes.Molecular Reproduction and Development, 2003 65:278~28233. Yao LJ,Fan HY, Tong C, Chen DY, Sun QY. Polo-like kinase-1 in porcine oocyte meiotic maturation, fertilization and early embryonic mitosis.Cellular and Molecular Biology, 2003, 49(3):399-40534. Quan HM,Fan HY, Meng XQ, Huo LJ, Chen DY, Schatten H, Yang PM, Sun QY. Effects of PKC activation on the meiotic maturation, fertilization, and early embryonic development of mouse oocytes.Zygote, 2003, 11 (4):329-33735. Meng XQ,Fan HY, Zhong ZS, Zhang G, Li YL, Chen DY, Sun QY. Localization of gamma-tubulin in mouse eggs during meiotic maturation, fertilization, and early embryonic development.Journal of Reproduction and Development, 2004, 50 (1):97-105.36. Huo LJ, Yu LZ, Liang CG,Fan HY, Chen DY, Sun QY. Cell cycle-dependent subcellular localization of cyclin B1, phosphorylated cyclin B1 and p34cdc2 during oocyte meiotic maturation and fertilization in mouse.Zygote. 2005, 13(1):45-53.37. Fan HY, Tong C, Chen DY, Sun QY. Roles of MAP kinase signaling pathway in meiosis of oocytes.Chinese Science Bulletin, 47:1157~116238. Fan HY, Tong C, Chen DY, Sun QY. Roles of protein kinase C in meiotic maturation and fertilization of oocytes.Progress in Natural Science, 2003, 13:401-40639. 范衡宇,佟超,陈大元,孙青原:蛋白激酶在卵母细胞减数分裂成熟和受精中的作用。 生物化学与生物物理学报,2002,34: 259-26540. 范衡宇,佟超,李满玉,孙青原:用激光共聚焦显微术在小鼠卵母细胞中检测蛋白激酶C。生物化学与生物物理进展,2001, 28: 900-90341. 范衡宇,佟超,孙青原:核糖体S6蛋白激酶p90rsk与卵母细胞减数分裂。生物化学与生物物理进展,2002,29: 506-50942. 范衡宇,孟小倩,霍立军,佟超,陈大元,孙青原. Detection of spindle-associated proteins in mammalian oocytes by confocal microscopy. 生物化学与生物物理进展, 2004, 31(1): 54-5843. 范衡宇,佟超,李世文,陈大元,孙青原:Microtubule organization during in vitro development of rat oocytes. 生物化学与生物物理进展,2002, 29 (5): 708-71344. 范衡宇,霍立军,孙青原:Roles of calmodulin-dependent protein kinase II in meiotic maturation and fertilization of oocytes. 生物化学与生物物理进展,2003, 30 (2) 171-17445. 范衡宇,白玉妍,杨增明:胚泡着床窗口的分子调控。生物化学与生物物理进展,2001, 28:11-1646. Li MY,Fan HY, Tong C, Chen DY, Xia GL, Sun QY. Mitogen-activated protein kinase regulates cell cycle progression in pig oocytes and fertilized eggs.Chinese Science bulletin, 2002, 47: 843-84747. 霍立军,范衡宇,陈大元,孙青原. 卵母细胞减数分裂和受精过程中MAPK和MPF的作用和相互调节. 自然科学进展, 2004,14: 256-26148. 白玉妍,范衡宇,杨增明:同源盒基因与哺乳动物生殖。 生物化学与生物物理进展,2001, 28: 329-33249. 范衡宇,佟超, 李世文,陈大元,孙青原:蛋白激酶C在小鼠卵母细胞成熟和受精中的作用。实验生物学报,2003, 36(1): 37-4250. 范衡宇,杨增明:乙醇对小鼠着床前胚胎体外发育的影响。 动物学报,2001, 47(1): 85-8851. 范衡宇,杨增明:催产素及其受体与哺乳动物的生殖。 动物学报,2001, 47(4):453-45852. 范衡宇,佟超,孙青原:丝裂原活化蛋白激酶(MAPK)信号通路的研究进展。动物学杂志, 2002, 37: 98-10253. 范衡宇,佟超,孙青原:丝裂原活化蛋白激酶(MAPK)信号通路与受精。 生命的化学,2001,21(4): 308~31054. 范衡宇:与“implantation”相关的几个概念的讨论。 细胞生物学杂志,2001, 23: 230-23155. 佟超,范衡宇,陈大元,孙青原:Parthenogenetic activation of mouse eggs induced by cycloheximide is calcium-dependent and can be blocked by okadaic acid. 动物学报, 2002, 48: 749-75356. 佟超,范衡宇,李满玉,陈大元,孙青原:Polo like激酶在细胞分裂中的作用研究进展。生理科学进展,2002,33: 45-4757. 霍立军,范衡宇,陈大元,孙青原:泛素-蛋白水解酶信号通路在卵母细胞减数分裂和受精中的作用。细胞生物学杂志, 2003, 25(2):73-7758. 范衡宇,杨增明:前列腺素及其受体与哺乳动物的生殖。生理科学进展,2000, 31(1): 75-78
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