E-commerce will gradually replace the traditional business model of the 21st century the core of economic activity. Enterprise Information is the basis for the implementation of e-commerce. Helpful-to-business e-commerce role, the same e-commerce business also brings the risk of short e-commerce enterprise is a double-edged sword, it is necessary to continue to practice in the process of reducing business risk e-commerce in enterprises, give full play to its advantage. Conduct in the business perspective in this article on the e-commerce, enterprise risk explained in detail and in depth analysis of e-commerce enterprise risk environment, and one by one analysis of the possible causes and risk response measures. For the smooth conduct of business e-commerce activities escort, to try to promote a new era of enterprise e-commerce activities. E-commerce will replace traditional business model and the 21st century is the core of economic activities. Enterprise informationization is the foundation of e-commerce. Electronic commerce is not only the essence through the network, but using the Internet shopping, thoroughly change the traditional technology of business operation mode. Information technology is that it is not true that the traditional working methods, and it is more efficient to enterprise broke traditional work rules, and create a new way of working, this is the core content of the enterprise restructuring. Information technology is enterprise restructuring, the starting point is the ultimate goal of enterprise restructuring of the vehicle. E-commerce has helped to enterprise, e-commerce has also brought to the business risks, anyhow e-commerce to enterprise is a double-edged sword, in the practice process, reduce the management risk of the enterprise that e-commerce in enterprise in its biggest advantage.