山大陈强研究方向及发表论文

1994年3月于日本东北大学药学部药品物理化学专业获得药学博士学位。现任南开大学特聘教授，博士生导师。个人学习和工作经历：－ 南开大学化学系物理化学专业，获得理学学士学位；－ 日本东北大学药学部药品物理化学专业，获得药学硕士、药学博士学位；－ 日本东北大学药学研究科任教并完成在职博士后研究，成为东北大学药学部创建以来第一位外籍教员；－ 至今 任教于南开大学生命科学学院，并创建生物传感器实验室。兼任生物活性材料教育部重点实验室副主任，建立了新型诊断材料领域，开展了分子间相互作用和分子识别的新型分析技术、中药作用机理及方剂配伍规律研究新方法的构建，功能微生物及其在环保、农业中的应用等跨学科的研究。目前的主要研究方向：生物电分析化学、生物医学传感技术、中药药理及药物分析研究成果：在纳米新材料光电化学技术、高性能纳米结构固定化酶电极制备技术、分子间相互作用和分子识别的新型分析技术、中药作用机理及方剂配伍规律研究新方法的构建等方向取得了显著成果。在国内外核心刊物发表论文80余篇，其中40余篇被SCI、EI收录，已授权专利6项，申请中专利1项。主持和分担了国家自然科学基金、“863”计划、教育部、天津市等科研项目十余项，研究成果获1997年日本文部省奖励研究A和2005年度天津市自然科学二等奖（编号2005ZR-2-011-R1）。研究生培养：获2006年度南开大学“敬业”奖教金一等奖。指导博士研究生中有两名分别于2005、2006年获得“南开十杰”称号，所指导研究生多次获得“南开大学优秀硕士毕业论文”及“南开大学优秀毕业生”奖励。为研究生开设三门课程：“物理化学在生命体系中的应用”（硕士生）、 “生物电化学”（ 博士生）、“生物传感器的原理与技术” （ 博士生）。硕士生、博士生招生专业：生物化学与分子生物学、动物学代表性文章目录： Zhao, Mingqiang Qiao, Feng Yin, Bin Shao, Baoyan Wu, Yanyan Wang, Xinsheng Wang, Xia Qin, Sha Li, Lei Yu, Qiang Chen. Amperometric glucose biosensor based on self-assembly hydrophobin with high efficiency of enzyme utilization. Biosensors & Bioelectronics, 2007,22:3021-3027 (SCI, IF ) Wu, Shihua Hou，Feng Yin, Zixia Zhao, Yanyan Wang, Xinsheng Wang, Qiang Chen. Amperometric glucose biosensor based on multilayer films via layer-by-layer self-assembly of multi-wall carbon nanotubes, gold nanoparticles and glucose oxidase on the Pt electrode. Biosensors &Bioelectronics,2007,22:2854-2860 (SCI, IF ) Wu, Shihua Hou, Feng Yin, Jing Li, Zixia Zhao, Jiadong Huang, Qiang Chen. Amperometric Glucose Biosensor Based on Layer-by-layer Assembly of Multilayer Films Composed of Chitosan, Gold Nanoparticals and Glucose Oxidase Modefied Pt Electrode. Biosensors &Bioelectronics,2007,22:838-844 (SCI, IF ) Shi, Yu Yang, Jiadong Huang, Zixia Zhao, Xinhua Xu, Jun-ichi Anzai, Tetsuo Osa, Qiang Chen. Amperometric Choline Biosensors Prepared by Layer-by-layer Deposition of Choline Oxidase on the Prussian Blue-Modified Platinum Electrode. Talanta,2006,70:852-858(SCI, IF ) Bao-Yan, LI Jing, HUANG Jia-Dong, Wang Yanyan, Yin Huijun, Chen Keji, CHEN Qiang. Real time kinetic analysis of the interaction between interleukin-1α and soluble interleukin-1 receptor using a resonant mirror biosensor. Analytica Chimica Acta, 2006, 557: 106-110(SCI, IF )主要学术论文韩松岩, 刘东波, 黄亮, 王深琪, 刘清平, 陈强. Monitoring adsorption in situ and kinetic studies of low-density lipoprotein onto cholesterol modified dextran using qua. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 26-6-1166. 2005-1-1李静,黄加栋,吴宝艳,陈强. Effects of propyl gallate on interaction between TNF-alpha and sTNFR-I using an affinity biosensor. ACTA PHARMACOLOGICA SINICA 26-10-1212. 2005-1-1史海滨，赵紫霞,宋昭,黄加栋,杨钰,陈强. Fabricating of acetylcholine biosensor by a layer-by-layer deposition technique for determining trichlorfon. ELECTROANALYSIS 17-14-1285. 2005-1-1陈强, 韩君, 史海滨,吴宝艳, 许鑫华. Use of Chitosan for developing layer-by-layer multilayer thin films containing glucose oxidase for biosensor applications. Sensor Letters v 2-n 2-p 102-105. 2005-1-1史海滨, 宋昭, 黄加栋,杨钰,赵紫霞, 陈强. Effects of the type of polycation in the coating films prepared by a layer-by-layer deposition technique on the properties of amperometric choline sensors. Sensors and Actuators, B: Chemical v 109-n 2-p 341-347. 2005-1-1史海滨, 宋昭, 黄加栋,杨钰,赵紫霞, 陈强. Effects of the type of polycation on the amperometric response of choline biosensors prepared by a layer-by-layer deposition technique. Materials Science and Engineering C v 25-n 4-p 433-435. 2005-1-1吴宝艳, 许鑫华, 史海滨, 韩松岩,宋岩、 黄亮, 陈强. Effect of cellulose acetate diffusion restricting membrane on the glucose biosensor. Tianjin Daxue Xuebao (Ziran Kexue yu Gongcheng Jishu Ban)/Journal of Tianjin University Science and Technology v 38-n 6-p 513-517. 2005-1-1尹峰;赵紫霞; 吴宝艳;王新胜; 王艳艳;陈强. Glucose biosensor based on layer-by-layer assembly of multi-walled carbon nanotubes and polyallylamine. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 35-7-1021-1024. 2007-1-1刘强; 许鑫华;张春怀; 陈强. Electrochemical deposition of composite films composed of polyaniline and chitosan for biosensor applications. SENSOR LETTERS 5-2-459-462. 2007-1-1赵紫霞; 乔明强; 尹峰; 邵兵; 吴宝艳; 王艳艳; 王新胜; 秦霞; 李莎; 于雷; 陈强. Amperometric glucose biosensor based on self-assembly hydrophobin with high efficiency of enzyme utilization. BIOSENSORS & BIOELECTRONICS 22-12-3021-3027. 2007-1-1吴宝艳;侯识华; 尹峰; 赵紫霞; 王艳艳; 王新胜; 陈强. Amperometric glucose biosensor based on multilayer films via layer-by-layer self-assembly of multi-wall carbon nanotubes, gold nanoparticles and glucose oxidase on the Pt electrode. BIOSENSORS & BIOELECTRONICS 22-12-2854-2860. 2007-1-1刘东波; 贺秉军;韩松岩; 王申奇; 刘清平; Jun-ichi, A; Osa, T; 陈强. An adsorption behavior of low-density lipoprotein onto cholesterol-modified dextran studied by a quartz crystal microbalance. MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS 27-4-665-669. 2007-1-1黄加栋; 宋昭; 李静; 杨钰; 史海滨; 吴宝艳; Anzai, JI; Osa, T; 陈强. A highly-sensitive L-lactate blosensor based on sol-gel film combined with multi-walled carbon nanotubes (MWCNTs) modified electrode. MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS 27-1-29-34. 2007-1-1吴宝艳; 侯识华; 尹峰; 李静; 赵紫霞; 黄加栋; 陈强. Amperometric glucose biosensor based on layer-by-layer assembly of multilayer films composed of chitosan, gold nanoparticles and glucose oxidase modified Pt electrode. BIOSENSORS & BIOELECTRONICS 22-6-838-844. 2007-1-1宋昭; 黄加栋; 史海滨; 吴宝艳; 赵紫霞;陈强. Highly sensitive choline biosensor based on nanotube modified pt electrode combined with sol-gel immobilization. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 34-7-910-914. 2007-1-1Li, J; Huang, JD; Wu, BY; Song, Z; Chen, Q. Optical biosensor analysis in studying propyl gallate binding to endothelin-1. SENSOR LETTERS 3-4-296. 2006-1-1Chen, Q; Huang, JD; Yin, HJ; Chen, KJ; Osa, T. The applications of affinity biosensors: IAsys biosensor and quartz crystal microbalance to the study on interaction between Paeoniae radix 801 and endothelin-1. SENSORS AND ACTUATORS B-CHEMICAL 115-1-116. 2006-1-1Huang, JD; Yang, Y; Shi, HB; Song, Z; Zhao, ZX; Anzai, J; Osa, T; Chen, Q. Multi-walled carbon nanotubes-based glucose biosensor prepared by a layer-by-layer technique. MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS 26-1-113. 2006-1-1Song, Z; Huang, JD; Wu, BY; Shi, HB; Anzai, JI; Chen, Q. Amperometric aqueous sol-gel biosensor for low-potential stable choline detection at multi-wall carbon nanotube modified platinum electrode. SENSORS AND ACTUATORS B-CHEMICAL 115-2-626. 2006-1-1Shi, H; Yang, Y; Huang, JD; Zhao, ZX; Xu, XH; Anzai, J; Osa, T; Chen, Q. Amperometric choline biosensors prepared by layer-by-layer deposition of choline oxidase on the Prussian blue-modified platinum electrode. TALANTA 70-4-852. 2006-1-1Wu, BY; Wang, YY; Li, J; Song, Z; Huang, JD; Wang, XS; Chen, Q. An optical biosensor for kinetic analysis of soluble Interleukin-1 receptor I binding to immobilized Interleukin-1 alpha. TALANTA 70-3-485. 2006-1-1Xu, XH; Ren, GL; Cheng, J; Liu, Q; Li, DG; Chen, Q. Layer by layer self-assembly immobilization of glucose oxidase onto chitosan-graft-polyaniline polymers. JOURNAL OF MATERIALS SCIENCE 41-10-3147. 2006-1-1Wu, Bao-Yan; Li, Jing; Huang, Jia-Dong; Wang, Yan-Yan; Yin, Hui-Jun; Chen, Ke-Ji; Chen, Qiang. Real time kinetic analysis of the interaction between interleukin-1α and soluble interleukin-1 receptor I using a resonant mirror biosensor. Analytica Chimica Acta v 557-n 1-2-p 106-110. 2006-1-1Wu, Baoyan; Li, Jing; Shi, Haibin; Huang, Jiadong; Anzai, Junichi; Osa, Tetsuo; Chen, Qiang. Ferrocene-mediated anti-interfering glucose biosensor based on glutin and cellulose acetate. High Technology Letters v 12-n 3-p 263-266. 2006-1-1Yanyan Wang, Xinsheng Wang, Baoyan Wu, Zixia Zhao, Feng Yin, Sha Li, Xia Qin, Qiang Chen. Dispersion of single-walled carbon nanotubes in poly(diallyldimethylammonium chloride) for prepara. Sensors and Actuators B李莎 王艳艳 赵紫霞 秦霞 王新胜 吴宝艳 陈强. 基于纳米材料、聚电解质制备高性能乙醇生物传感器. 分析化学 36-2-227-230. 2008-2-1秦霞王艳艳赵紫霞王新胜李莎于敏黄楠苗智颖陈强. 层层自组装制备基于多壁碳纳米管的胆碱生物传感器. 分析化学 36-6-827-830. 2008-6-1Bao-Yan Wu, Shi-Hua Hou, Liang Huang, Feng Yin, Zi-Xia Zhao, Jun-Ichi Anzai, Qiang Chen. Oriented immobilization of immunoglobulin G onto the cuvette surface of the resonant mirror biosenso. Materials Science and Engineering C 28-7-1065-1069. 2008-8-1Jiadong Huang, Jing Li, Yu Yang, Xinsheng Wang, Baoyan Wu, Qiang Chen. Development of an amperometric L-lactate biosensor based on L-lactate oxidase immobilized through silica sol-gel film on multi-walled carbon nanotubes/platinum nanoparticle modified glassy carbon electrode. Materials Science and Engineering C 28-7-1070-1075. 2008-8-1Bao-Yan Wu, Shi-Hua Hou, Min Yu, Xia Qin, Sha Li, Qiang Chen. Layer-by-layer assemblies of chitosan/multi-wall carbon nanotubes and glucose oxidase for amperometric glucose biosensor applications. Materials Science and Engineering C 29-1-346-349. 2009-1-1于敏，王会才，秦 霞，王新胜，昊宝艳，陈 强. 纳米银/半胱氨酸修饰葡萄糖生物传感器的研究. 传感器与微系统 27-10-24-26. 2008-10-1Xia Qin, Huicai Wang, Xinsheng Wang, Sha Li, Zhiying Miao, Nan Huang, Qiang Chen. Amperometriccholinebiosensorsbased on multi-wallcarbonnanotubes and layer-by-layer assembly of multilayer films composed of Poly(diallyldimethylammonium chloride) and choline oxidase . Materials Science and Engineering: CZi-Xia Zhao, Hui-CaiWang, Xia Qin, Xin-ShengWang, Ming-Qiang Qiao, Jun-ichi Anzaib, Qiang Chen. Self-assembled film of hydrophobins on gold surface and its application to electrochemical biosensing. Colloids and Surfaces B: BiointerfacesWei Zhao, Huicai Wang, Xia Qin, Xinsheng Wang, Zixia Zhao, Zhiying Miao, Lili Chen, Miaomiao Shan, Yuxin Fang, Qiang Chen. A novel nonenzymatic hydrogen peroxide sensor based on multi-wall carbon nanotube/silver nanoparticle nanohybrids modified gold electrode. TalantaHuicaiWang, XinshengWang, Xiaoqing Zhang, Xia Qin, Zixia Zhao, Zhiying Miao, Nan Huang, Qiang Chen. A novel glucose biosensor based on the immobilization of glucose oxidase onto gold nanoparticles-modified Pb nanowires. Biosensors and BioelectronicsSha Li, Yanyan Wang, Zixia Zhao, Xia Qin, Xinsheng Wang, Min Yu, Zhiying Miao, Baoyan Wu, Qiang Chen. Amperometric Ethanol Biosensor Based on Layer-by-Layer Deposition of Alcohol Oxidase on the Platinum. Sensor lettersXia Qin, Huicai Wang, Xinsheng Wang, Zhiying Miao, Lili Chen, Wei Zhao, Miaomiao Shan, Qiang Chen. Amperometric biosensors based on gold nanoparticles-decorated multiwalled carbon nanotubes poly(diallyldimethylammonium chloride) biocomposite for the determination of choline. Sensors and Actuators B陈丽丽, 王会才, 秦霞, 王新胜, 赵紫霞, 苗智颖, 赵薇, 单苗苗, 陈强. 层层自组装技术制备PDDA-多壁碳纳米管-胆碱生物传感器. 分析化学Zixia Zhao, Qiang Chen, Jun-ichi ANZAI. Horseradish peroxidase microcapsules based on layer-by-layer polyelectrolyte deposition. Journal of Environmental Sciences 21- supplement 1-Yanyan Wang, Qiang Chen, Xiangqun Zeng. Potentiometric biosensor for studying hydroquinone cytotoxicity in vitro. Biosensors and Bioelectronics

1967年7月商县师范学校毕业，1996年2月陕西教育学院卫星函授专科毕业，现任洛南县祖师中学校长兼党支部书记。从事教育工作30多年来，一直在中学担任教学和领导职务，负责学校管理工作。在教学管理中，坚持从单位实际出发，勤俭节约，多方筹措资金，想方设法改变学校的校容校貌，改善办学条件，优化育人环境，完成了双基任务。近几年来，年年完成和超额完成中考指标任务。初一、二年级会考，连续五年获区、镇第一名。1998年有11名考生升入中专，其中有5名音乐考生，占全县音乐考生录取的一半。承担的毕业班数学课，95级张荣斌同学中考连续两次获全县数学单科第一名；王英英同学获地区奥数一等奖；坚持经常听课、查课、评课。积极参加教研教改活动，总结经验，所撰写的课堂教学的时间安排初中数学复习课之我见、以情治学出硕果等10多篇论文分别发表于《商洛师专学校》、《商州教坛》、《作文精选》等刊物上。

1. Shuang-Yu Lv, Yan-Jie Yang, Yao-Jun Qin, Jia-Run Mo, Ning-Bo Wang, Yi-Jing Wang, Qiang Chen∗ Central apelin-13 inhibits food intake via the CRF receptor in mice. Peptides 32 (2011) doi:. F Yue, XL Tang, DJ Zhang, XF Yan, Y Xin, and Q Chen*. Body temperature and standard metabolic rate of female viviparous lizard Eremias multiocellata during reproduction. Canadian Journal of Zoology 90(2012):79–843. Y. Xin, X. Tang, F. Yue, D. Zhang, X. Yan, C. Wang, Q. Chen* Isolation and Sequence Analysis of Sox Genes from lizard Eremias multiocellata. Russian Journal of Genetics (2012) 48(1). Ai-min Yang, Yue-ke Ji, Shu-fang Su, Shao-bin Yang, Song-song Lu, Ze-yun Mi, Qing-zhen Yang, Qiang Chen∗ Intracerebroventricular administration of neuronostatin induces depression-like effect in forced swim test of mice. Peptides 32 (2011) 1948–19525. Ai-min Yang, Wan-wen Ge, Song-song Lu, Shao-bin Yang, Shu-fang Su, Ze-yun Mi, Qiang Chen∗ Central administration of neuronostatin induces antinociception in mice. Peptides 32 (2011) 1893–19016. Shao-bin Yang, Ai-min Yang, Shu-fang Su, Hui-hui Wang, Ning-bo Wang, Qiang Chen* Neuronostatin induces hyperalgesia in formalin test in mice, Neurosci. Lett. (2011),doi:. Xue-Feng Yan, Xiao-Long Tang, Feng Yue, De-Jiu Zhang, Ying Xin, Cui Wang, Qiang Chen* Influence of ambient temperature on maternal thermoregulation and neonate phenotypes in a viviparous lizard, Eremias multiocellata, during the gestation period. Journal of Thermal Biology 36 (2011) 187–1928. 吕双瑜 杨爱民 修明慧 杨艳杰 陈强* 侧脑室注射脂肪酸合成酶摄制剂C75对小鼠学习记忆的影响，中华行为医学与脑科学杂志 2011,20（1）：51-529. Shuang-Yu Lv, Yan-Jie Yang, Yao-Jun Qin, Wei Xiong and Qiang Chen* Effect of centrally administered apelin-13 on gastric emptying and gastrointestinal transit in mice. Peptides 32 (2011) 978–98210. Qing-Zhen Yang, Song-Song Lu, Xiao-Zhu Tian, Ai-Min Yang, Wan-Wen Ge, Qiang Chen∗The antidepressant-like effect of human opiorphin via opioid-dependent pathways in mice. Neuroscience Letters 489 (2011) 131–13511. Yan-Jie Yang, Shuang-Yu Lv, Ming-Hui Xiu, Ning Xu, Qiang Chen* Intracerebroventricular administration of apelin-13 inhibits distal colonic transit in mice. Peptides 31 (2010) 2241–224612. De-Jiu Zhang, Feng Yue, Xiao-Long Tang, Zhuo Chen, Ren-De Li and Qiang Chen* Effect of gestation temperature on sexual and morphological phenotypes of offsprings in a viviparous lizard, Eremias multiocellata. Journal of Thermal Biology 35 (2010) 129–13313. Xiao-zhu Tian, Juan Chen, Wei Xiong, Tian He, Qiang Chen* Effects and underlying mechanisms of human opiorphin on colonic motility and nociception in mice. Peptides 30(2009):1348-5414. Ning Xu, Haiting Wang, Li Fan, Qiang Chen* Supraspinal administration of apelin-13 induces antinociception via the opioid receptor in mice. Peptides 30 (2009) 1153–115715. Lai-Fu Li, Yan-Yu Lu, Wei Xiong, Juan-Ying Liu, Qiang Chen* Effect of centrally administered C75, a fatty acid synthase inhibitor, on gastric emptying and gastrointestinal transit in mice. European Journal of Pharmacology 595 (2008) 90–9416. Juan Chen，Yuan Long，Min Han，Ting Wang, Qiang Chen*, Rui Wang* Water-solutable derivates of propolis mitigates scopolamine-induced learning and memory impairment in mice. Pharmacology, Biochemistry and Behavior 2008; 90:441-44617. Kui Zai, Li Hu, Juan Chen, Caiyun Fu, Qiang Chen* Chrysin induced hyperalgesia via GABAA receptor in mice. Planta Medica 2008; 74:1229-123418. 欧阳建梅 陇源 房克难 王锐 陈强*, 蜂胶乙醇提取物(EEP)对豚鼠胸主动脉的舒张作用, 现代生物医学进展 2007(9):1286-128919. Qian-Yu Zhao, Qiang Chen, Yun Feng, Xin Lin and Rui Wang* [TIC4] endomorphins, analogues of endomorphins, have significantlynhanced vasorelaxant effects in rat aorta rings. Protein Pept. Lett. 2005,12(4), 323-32620. Pei-Han Xu, Qiang Chen, Hong-Fang Li, Ye Yu, Xiang Yan, Rui Wang* The relaxant effect of dobutamine on porcine coronary arterial ring segments. Pharmazie 2005, 60 375-37721. Yun Feng, Qian-Yu Zhao, Qiang Chen, Rui Wang* (2005) Vasorelaxant responses to endomorphin1[ ], analogues of endomorphins, in rat aorta rings.and endomorphine2[ pharmazie 60: Fu, Zi-Qing Kong, Kai-Rong Wang, Qi Yang, Kui Zhai,Qiang Chen,*Rui Wang*Effects and mechanisms of supraspinal administration of rat/mousehemokinin-1, a mammalian tachykinin peptide, on nociception in mice. Brain Research, 2005,1056, 51-5823. Qian-Yu Zhao, Qiang Chen, Ding-Jian Yang, Yun Feng, Yuan Long, Peng Wang, Rui Wang, Endomorphin 1[c] and endomorphin 2[c], endomorphins analogues containing a reduced (CH2NH) amide bond between Tyr1 and Pro2, display partial agonist potency but significant antinociception. Life Sci., 2005,77, 1155-116524. 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