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论文详情Developmentandapplicationofnovelelectrophilicwarheadsintargetidentificationanddrugdiscovery...Meanwhile,manynovelinhibitorsbearingnewreactivewarheadweredevelopedanddisplayedremarkablepharmaceuticalproperties.Inthis...
AnelectrophilicwarheadlibraryformappingthereactivityandaccessibilityoftractablecysteinesinproteinkinasesEuropeanJournalofMedicinalChemistry(IF6.514)PubDate:2020-09-12,DOI:10.1016/j.ejmech.2020.112836
NovelElectrophilicWarheadTargetingaTriple-NegativeBreastCancerDriverinLiveCellsRevealedby“InverseDrugDiscovery”JournalofMedicinalChemistry(IF7.446)PubDate:2021-10-08,DOI:10.1021/acs.jmedchem.0c02024
Amodelwarheadthatcancontrolthedistributiondensityoftherodwasdevelopedanddemonstratedbyascaledexperiment.Thisdesignwouldbeanextensionofthehit-to-killwarheadconcept.EinAnti-TBMGefechtskopfDasKonzepteinesATBM(Anti-taktischerballistischerFlugkrper)-Gefechtskopfeswirdvorgestellt,derungefhr1000Massen/Splitter(rods)ausstt.
DescribedinthisArticlearenovelα-acyloxymethylketonewarheadpeptidomimeticcompoundswithasix-memberedlactamglutaminemimicinP1.CompoundswithpotentSARS-CoV-23CLproteaseandinvitroviralreplicationinhibitionwereidentifiedwithlowcytotoxicityandgoodplasmaandglutathionestability.
Selectableinitiation-pointfragmentwarhead.Afragmentwarheadincludinganexplosivedividedintoapluralityofaxiallyadjacentsegmentsbydetonationwavebarriers.Atleastonedetonatorisembeddedineachsegment.Afragmentationlayerencasestheexplosive,andafuzeselectivelyactivatesatleastonedetonatorineachsegmentto...
IdentificationofpyrogallolasawarheadindesignofcovalentinhibitorsfortheSARS-CoV-23CLproteaseNatureCommunications(IF14.919)Pub…
本文由个人公众号“精准药物”授权发布（版权所有，转载请联系公众号），阅读原文来自暨南大学的科研团队在最新一期的JMC上以“NovelElectrophilicWarheadTargetingaTriple-NegativeBreastCancerDriverinLiveCellsRevealedby“InverseDrugDiscovery””为题发表论文，报道基于“反向药物发现”策略，首次研…
该课题组在之前发展的一系列可逆共价的谷胱甘肽（GSH）荧光探针基础上，进一步提出了基于氰基丙烯酰胺为可逆共价反应基团的新型PROTAC分子。.作者推测可逆共价PROTAC分子不仅可以显著提高与靶向蛋白的结合力，而且在靶向蛋白降解后，PROTAC分子仍然可以被...
中北大学学位论文不同枪管截面形状对弹头挤进过程中动态应力的影响分析摘要弹头在挤进过程中，由于受到火药燃气压力、导转侧力、挤进阻力以及高温的作用，加之枪/弹之间摩擦特性的不同，使得弹头容易发生变形和损伤，而截面形状的不同，将导致弹头挤进中的动态应力变化的...
论文详情Developmentandapplicationofnovelelectrophilicwarheadsintargetidentificationanddrugdiscovery...Meanwhile,manynovelinhibitorsbearingnewreactivewarheadweredevelopedanddisplayedremarkablepharmaceuticalproperties.Inthis...
AnelectrophilicwarheadlibraryformappingthereactivityandaccessibilityoftractablecysteinesinproteinkinasesEuropeanJournalofMedicinalChemistry(IF6.514)PubDate:2020-09-12,DOI:10.1016/j.ejmech.2020.112836
NovelElectrophilicWarheadTargetingaTriple-NegativeBreastCancerDriverinLiveCellsRevealedby“InverseDrugDiscovery”JournalofMedicinalChemistry(IF7.446)PubDate:2021-10-08,DOI:10.1021/acs.jmedchem.0c02024
Amodelwarheadthatcancontrolthedistributiondensityoftherodwasdevelopedanddemonstratedbyascaledexperiment.Thisdesignwouldbeanextensionofthehit-to-killwarheadconcept.EinAnti-TBMGefechtskopfDasKonzepteinesATBM(Anti-taktischerballistischerFlugkrper)-Gefechtskopfeswirdvorgestellt,derungefhr1000Massen/Splitter(rods)ausstt.
DescribedinthisArticlearenovelα-acyloxymethylketonewarheadpeptidomimeticcompoundswithasix-memberedlactamglutaminemimicinP1.CompoundswithpotentSARS-CoV-23CLproteaseandinvitroviralreplicationinhibitionwereidentifiedwithlowcytotoxicityandgoodplasmaandglutathionestability.
Selectableinitiation-pointfragmentwarhead.Afragmentwarheadincludinganexplosivedividedintoapluralityofaxiallyadjacentsegmentsbydetonationwavebarriers.Atleastonedetonatorisembeddedineachsegment.Afragmentationlayerencasestheexplosive,andafuzeselectivelyactivatesatleastonedetonatorineachsegmentto...
IdentificationofpyrogallolasawarheadindesignofcovalentinhibitorsfortheSARS-CoV-23CLproteaseNatureCommunications(IF14.919)Pub…
本文由个人公众号“精准药物”授权发布（版权所有，转载请联系公众号），阅读原文来自暨南大学的科研团队在最新一期的JMC上以“NovelElectrophilicWarheadTargetingaTriple-NegativeBreastCancerDriverinLiveCellsRevealedby“InverseDrugDiscovery””为题发表论文，报道基于“反向药物发现”策略，首次研…
该课题组在之前发展的一系列可逆共价的谷胱甘肽（GSH）荧光探针基础上，进一步提出了基于氰基丙烯酰胺为可逆共价反应基团的新型PROTAC分子。.作者推测可逆共价PROTAC分子不仅可以显著提高与靶向蛋白的结合力，而且在靶向蛋白降解后，PROTAC分子仍然可以被...
中北大学学位论文不同枪管截面形状对弹头挤进过程中动态应力的影响分析摘要弹头在挤进过程中，由于受到火药燃气压力、导转侧力、挤进阻力以及高温的作用，加之枪/弹之间摩擦特性的不同，使得弹头容易发生变形和损伤，而截面形状的不同，将导致弹头挤进中的动态应力变化的...
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