molecules期刊投稿图形摘要必须要有
图形摘要是论文主要调查结果的简明形象化概要，如今在Cell系列等越来越多的国际期刊中，要求论文要有图形摘要。以下是我们总结的图形摘要写作要领：
一、图形要一针见血，不言自明。一般来说，好的图形摘要应当能准确表达出文章的主旨信息，且图形清晰、可读性强。因此，在确保图形聚焦文章中主要研究结果的基础之上，要尽量避免分散读者的注意力，而这就需要图形摘要尽量使用直观且不需要揣测含义的图形，如一些约定俗成的图例或公知公用的符号等，可让读者可依据已有经验和所有掌握的知识在短时间内领会其所代表的含义，从而缩短认知过程。
二、切忌图不对文。图形摘要的主要目的在于将一篇文章的最重要、最精华的信息提炼成为一张图片，便于读者理解，抑或重新绘制来概括文章研究的新发现或新成果。因而研究者在开始制作图片之前，理应重新审视自己的文章，并确定什么是最值得展示给读者的信息。
朋友，根据我多年从事文字工作的经验，我认为：如果投稿更有针对性，命中率会更高一些。这就关系到，你是哪里的？干什么的？写的稿件是什么体裁？什么内容？如果说投稿的话，最好投当地的报刊、网络或者是你从事的职业报刊发表，要投哪个媒体首先要研究哪个媒体，看它需要什么内容、什么体裁、什么格式的稿件，“对症下”，这样会更轻松一些、方便一些，命中率会更高一些。如果你能够告诉我你的具体情况（干什么工作，哪里的，写的小说的大致内容等），我可以给你一些建议。我1993年开始在部队时开始发表各类文章，包括：报告文学、新闻、诗歌、散文、小说、评论等体裁的，到目前发表的大约5000篇左右吧，有40多篇获奖。另外：投稿时，第一要有信心，第二要投对报刊媒体，这两点非常重要。祝你成功！
1.所有问题必须逐条回答。
2.尽量满足意见中需要补充的实验。
3.满足不了的也不要回避，说明不能做的合理理由。
4.审稿人推荐的文献一定要引用，并讨论透彻。
以下是本人对审稿人意见的回复一例，仅供参考。
续两点经验：
1. 最重要的是逐条回答，即使你答不了，也要老实交代；不要太狡猾，以至于耽误事；
2. 绝大部分实验是不要真追加的，除非你受到启发，而想改投另外高档杂志----因为你既然已经写成文章，从逻辑上肯定是一个完整的 “story” 了。
以上指国际杂志修稿。国内杂志太多，以至于稿源吃紧，基本没有退稿，所以你怎么修都是接受。
我的文章水平都不高，主要是没有明显的创新性，也很苦恼。但是除了开始几篇投在国内杂志外，其他都在国际杂志（也都是SCI）发表。以我了解的情况，我单位其他同志给国内杂志投稿，退稿的极少，只有一次被《某某科学进展》拒绝。究其原因，除了我上面说的，另外可能是我单位写稿子还是比较严肃，导师把关也比较严的缘故。
自我感觉总结（不一定对）：
1）国内杂志审稿极慢（少数除外），但现在也有加快趋势；
2）国内杂志编辑人员认真负责的人不多，稿子寄去后，少则几个月，多则一年多没有任何消息；
3）国内杂志要求修改的稿子，如果你自己不修，他最后也给你发；
4）国外杂志要求补充实验的，我均以解释而过关，原因见少帖）。还因为：很少杂志编辑把你的修改稿再寄给当初审稿人的，除非审稿人特别请求。编辑不一定懂你的东西，他只是看到你认真修改，回答疑问了，也就接受了（当然高档杂志可能不是这样，我的经验只限定一般杂志（影响因子1-5）。
欢迎大家批评指正。
我常用的回复格式:
Dear reviewer:
I am very grateful to your comments for the manuscript. According with your advice, we amended the relevant part in manuscript. Some of your questions were answered below.
1）
2）
....
引用审稿人推荐的文献的确是很重要的，要想办法和自己的文章有机地结合起来。
至于实验大部分都可以不用补做，关键是你要让审稿人明白你的文章的重点是什么，这个实验对你要强调的重点内容不是很必要，或者你现在所用的方法已经可以达到目的就行了。
最后要注意，审稿人也会犯错误，不仅仅是笔误也有专业知识上的错误，因为编辑找的审稿人未必是你这个领域的专家。只要自己是正确的就要坚持。在回复中委婉地表达一下你的意见，不过要注意商讨语气哦！
我得回复格式是这样的：
Dear Professor xx:
Thank you very much for your letter dated xxx xx xxxx, and the referees’ reports. Based on your comment and request, we have made extensive modification on the original manuscript. Here, we attached revised manuscript in the formats of both PDF and MS word, for your approval. A document answering every question from the referees was also summarized and enclosed.
A revised manuscript with the correction sections red marked was attached as the supplemental material and for easy check/editing purpose.
Should you have any questions, please contact us without hesitate.
然后再附上Q/A，基本上嘱条回答，写的越多越好（老师语）。结果修改一次就接收了：）
我的回复，请老外帮忙修改了
Dear Editor:
Thank you for your kind letter of “......” on November **, 2005. We revised the manuscript in accordance with the reviewers’ comments, and carefully proof-read the manuscript to minimize typographical, grammatical, and bibliographical errors.
Here below is our description on revision according to the reviewers’ comments.
Part A (Reviewer 1)
1. The reviewer’s comment: ......
The authors’ Answer: .....
2. The reviewer’s comment: ......
The authors’ Answer: .....
...
...
Part B (Reviewer 2)
1. The reviewer’s comment: ......
The authors’ Answer: .....
2. The reviewer’s comment: ......
The authors’ Answer: .....
...
...
Many grammatical or typographical errors have been revised.
All the lines and pages indicated above are in the revised manuscript.
Thank you and all the reviewers for the kind advice.
Sincerely yours,
***
一个回复的例子(已接收)
Major comments:
1. The authors need to strengthen their results by including MMP secretion, and tran-matrigel migration by a positive control progenitor cell population i.e. enriched human CD34 cells obtained from mobilized PBL, since this is a more clinically relevant source of CD34 cells which has also been shown to secrete both MMP-9 and MMP-2 (ref. 11). CD34 enriched cells from steady state peripheral blood which also secrete MMPs are also of interest.
2. In fig 1C please specify which cell line represents MMP-negative cells. This needs to be clarified, as well as a better explanation of the method of the protocol.
3. The ELISA results are represented as "fold increase" compared to control. Instead, we suggest that standards should be used and results should be presented as absolute concentrations and only then can these results be compared to those of the zymography.
4. When discussing the results, the authors should distinguish clearly between spontaneous migration vs chemotactic migration. Furthermore, the high spontaneous migration obtained with cord blood CD34 cells should be compared to mobilized PBL CD34 enriched cells and discussed.
5. The authors claim that the clonogenic assay was performed to determine the optimum concentration for inhibition of MMP activity by phenanthroline and anti MMP-9 mAb, however they should clarify that this assay can only determine the toxicity of the inhibitors and not their optimal inhibitory concentrations.
Minor comments:
1. There are many spelling and syntax errors, especially in the results and discussion, which need correction.
a. Of special importance, is the percent inhibition of migration, which is described as percent of migration. i.e. pg 7:"Migration of CB CD34 was reduced to 73.3%?" Instead should read "Migration of CB CD34 was reduced by 73.3%?"
b. The degree symbol needs to be added to the numbers in Materials and methods.
2. It would be preferable to combine figure 1A and B, in order to confirm the reliability of fig. 1B by a positive control (HT1080).
Answer to referee 1 comment:
1. Mobilized peripheral blood is a more clinical source of CD34+ cells, so it is necessary to compare the MMP-9 secretion and trans-migration ability of CB CD34+ cells with that of mobilized PB CD34+ cells. However, we couldn't obtain enough mobilized PB to separate PB CD34+ cells and determine the MMP-9 secretion and migration ability, so we couldn’t complement the study on PB CD34+ cells in this paper. Results obtained by Janowska-Wieczorek et al found that mobilized CD34+ cells in peripheral blood express MMP-9. Furthermore, Domenech’s study showed that MMP-9 secretion is involved in G-CSF induced HPC mobilization. Their conclusions have been added in the discussion. In our present study, our central conclusion from our data is that freshly isolated CD34+ stem/progenitor cells obtained from CB produce MMP-9.
2. MMP-9 negative cell used in fig 1C was Jurkat cell. In zymographic analysis, MMP-9 was not detected in the medium conditioned by Jurkat cell. To exclude that the contaminating cells may play a role in the observed MMP-9 production, we screened the media conditioned by different proportion of CB mononuclear cells with MMP-9 negative cells by zymography. This result may be confusion. Actually, only by detecting the medium conditioned by 2X105 CB mononuclear cells (MNC)/ml (since the purities of CD34+ cell are more than 90%), it could exclude the MNC role. In the revised manuscript, we only detected MMP-9 activity and antigen level in the medium conditioned by 2X105 CB mononuclear cells (MNC)/ml. There is no MMP-9 secretion be detected in the medium conditioned by 2X105 CB MNC/ml. It excluded the possibility that the MMP-9 activity in CB CD34+ cells conditioned medium is due to the contamination by MNC.
3.In this revised paper, we have detected the MMP-9 antigen levels by using commercial specific ELISA kits (R&D System, sensitivity, 0.156ng/ml). Recombinant MMP-9 from R&D System was used as a standard. The results are expressed in the absolute concentration. The absolute concentration result has been added in the paper. As shown in Fig2, MMP-9 levels were detectable in both CB CD34+ cell conditioned medium and BM CD34+ cell conditioned medium. However, MMP-9 level was significantly higher in CB CD34+ cell conditioned medium than in BM CD34+ cell conditioned medium (0.406±0.133ng/ml versus 0.195±0.023ng/ml). Although gelatinolytic activity was not detected in media conditioned by CD34+ cells from BM, sensitivity of ELISA favors the detection of MMP-9 antigen in the BM CD34+.
4. In our study, to establish the direct link between MMP-9 and CB CD34+ cells migration, we only determined the role of MMP-9 in spontaneous migration of CB CD34+ cells, but not in chemotactic migration. Actually, regulation of hematopoietic stem cell migration, homing and anchorage of repopulation cells to the bone marrow involves a complex interplay between adhesion molecules, chemokines, cytokines and proteolytic enzymes. Results obtained by the groups of Voermans reveal that not only the spontaneous migration but also the SDF-1 induced migration of CB CD34+ cells is greatly increased in comparison to CD34+ cells from BM and peripheral blood.
5. CD34+ cells we obtained in each cord blood sample were very limited. It is not enough to screen the inhibitors concentrations to select the optimal inhibitory concentrations. In the blocking experiments, based on the concentrations used by others and the manufacturer's recommendation, we then determined the inhibitors concentrations by excluding the toxicity of the inhibitors in that concentration, which was determined by clonogenic assay.
Minor comments:
1.The spelling and syntax errors have been checked and corrected.
2.Since the results in figure 1A and B were obtained from two separated and parallel experiments, it is not fitness to combine two figures.
投稿Energy，35天后返回修改，给的大修，求教有经验的虫友如何回复审稿意见比较好。另外，为什么附件里只有一个人的审稿人意见？Dear***, The review of this paper is now complete, and I am including the Reviewers' reports (directly at the end of this email and sometimes as attachments). As you can see, one Reviewer recommends rejection, and the others recommend possible reconsideration after major revisions. If you are able to revise the manuscript thoroughly in response to the Reviewers' comments, I believe that it would be suitable for second review. I should add that, in view of the strong criticisms, anything but a thorough response and revision would just be an unfortunate waste of time. Once you have revised the paper accordingly, please submit with it a note describing in detail your response to these comments and a separate copy of the revised paper marked up to indicate where the revisions were made. NOTE: Upon submitting your revised manuscript, please upload the source files for your article. For additional details regarding acceptable file formats, please refer to the Guide for Authors at: When submitting your revised paper, we ask that you include the following items: Manuscript and Figure Source Files (mandatory) We cannot accommodate PDF manuscript files for production purposes. We also ask that when submitting your revision you follow the journal formatting guidelines. Figures and tables may be embedded within the source file for the submission as long as they are of sufficient resolution for Production. Refer to the Guide for Authors for additional information.http:// Highlights (mandatory) Highlights consist of a short collection of bullet points that convey the core findings of the article and should be submitted in a separate file in the online submission system. Please use 'Highlights' in the file name and include 3 to 5 bullet points (maximum 85 characters, including spaces, per bullet point). See the following website for more information Please note that this journal offers a new, free service called AudioSlides: brief, webcast-style presentations that are shown next to published articles on ScienceDirect (see also http://www.elsevier.com/audioslides). If your paper is accepted for publication, you will automatically receive an invitation to create an AudioSlides presentation. Thank you for your interest in ENERGY. Sincerely, Milorad Lj Bojic, Ph.D. Editor Reviewers' comments: Reviewer #1: Through a thorough reading and reviewing, the reviewer suggests that the following problems should be addressed and the manuscript should be modified. 1. Keywords should contain "Lauric acid". 2. XRD results reveal that the IKL and LA/IKL have the same diffraction peak at 2
你按审稿人的建议认认真真地修改，特别是第二个审稿人，说你的论文simple and less novelty，这是很大的硬伤，这个问题不解决，很难录用的。还有你们细节太不注意了，英语写作也要提高。
好好根据审稿意见修改文章，特别是意见不好的那位。每一天都要回复，并说明文章是怎么带的，或者对审稿意见进行解释。
我叫***，今年27岁。1997年7月我从**师范学校艺师美术专业计划内自费毕业。由于从97年起国家不再对自费生包分配，使我与“太阳底下最光辉的职业”失之交臂。幸好，当时河西马厂完小师资不足，经人介绍，我在该完小担任了一年的临时代课教师。回想起那段时光真是既甜蜜又美好，虽然代课工资很低，但听着同学们围在身旁“老师”、“老师”的叫个不停，看着那一双双布满信任的眼睛，那一张张稚气的小脸，生活中的所有不快都顿时烟消云散了。我原想，即使不能转正，只要学校需要，就是当一辈子代课教师我也心甘情愿。不料，1998年起国家开始清退临时工和代课教师，接到了学校的口头通知后，我怀着恋恋不舍的心情，静静地离开了学校。
自我介绍范文二
敬的领导：
您好！感谢您在百忙之中审阅我的自荐书，这对一个即将迈出校门的学子而言，将是一份莫大的鼓励。相信您在给予我一个机会的同时，您也多一份选择！即将走向社会的我怀着一颗热忱的心，诚挚地向您推荐自己！我叫***，是莆田学院小学教育专业2001届即将毕业的一名专科生，我怀着一颗赤诚的心和对事业的执著追求，真诚地向您推荐自己。
在校的五年里，我不断充实自己，全面发展，以锐意进取和踏实诚信的作风及表现赢得了老师和同学的信任和赞誉。我有较强的治理能力，活动组织策划能力和人际交往能力。从2001年起我一直担任年段学生会主席，曾担任班长，副班长，校学生会委员等职务，作为学生干部，我工作认真，学习刻苦，成绩优异，得到学校领导、老师、同学的一致认可和好评，先后获得校“优秀共青团员”，“三好学生”，“优秀学生干部”，市“优秀学生干部”等荣誉称号。
作为师范生，我对基本功尤为重视，平时坚持勤练书法，钢笔字、粉笔，基本功扎实，三笔一画考核全部过关；通过努力，我顺利通过了全国普通话等级考试，中国人才指南网并以优异的成绩获得二级甲等证书；国家计算机水平一级考试成绩优异。大专期间，我表现突出，成绩优异，评得一等补贴金，二等奖学金。作为学校《星空》文学社的社员，我认真写作，积极投稿，2004年11月获得省“陶行知征文”比赛第三名。2005年光荣的成为入党积极分子。
大学里，丰富多彩的社会生活和井然有序而又紧张的学习气氛，使我得到多方面不同程度的锻炼和考验；正直和努力是我做人的原则；沉着和冷静是我遇事的态度；爱好广泛使我非常充实；众多的朋友使我倍感富有！我很强的事业心和责任感使我能够面对任何困难和挑战。
作为一名即将毕业的学生，我的经验不足或许让您犹豫不决，但请您相信我的干劲与努力将弥补这暂时的不足，也许我不是最好的，但我绝对是最努力的。我相信：专心一定能赢得出色！
"良禽择木而栖，士不知已者而搏。"愿您的慧眼，开启我人生的旅程。
再次感谢您为我留出时间，来阅读我的自荐书，祝您工作顺心！期待您的希望！
此致敬礼！
Dear examiners,, judges: pass the exam, today, I written in this position first record into the interview. For me, this opportunity to appear particularly valuable.
I call * * *, this year 27 years old. July 1997 me from * * normal school art teacher art professional inside the plan at graduation. From 1997 to within country no longer ZiFeiSheng bag distributive, that I should go up with "the sun most glary vocation" over. Fortunately, tattenai machang small teachers is insufficient, the people in this small introduction, I served as a year of temporary substitute teacher. Recall that time which was both sweet and good, although substitute a low salary, but listen students around the side "teacher" and "teacher" growled and looked at the pairs of eyes, that is full of trust every childishness little face, all the unpleasant life all suddenly vanished. I wanted to, even if it does not become a full member, as long as the school needs, is when the lifetime class teacher I also willingly. And behold, since 1998 countries began to repel temporary and class teacher, received the school verbally notify after, I was reluctant to part with the mood, silently leave the school.
Introduce two essays
Worship of the leadership:
Hello! Thank you in spite of being very busy to review my ZiJianShu, this is taken to a school students are concerned, is a great encouragement. Believe that you give me a chance in the meanwhile, you also to a more choice! Is heading for society I with a single warmly heart, sincerely recommend oneself! My name is * * *, institute of education specialized elementary school is putian 2001 session to graduate from a: firstly, I with a sincere heart and to the cause of the persistent pursuit, sincerely to recommend myself.
In five years, I constantly enrich himself, all-round development, in order to forge ahead and steadfast integrity style and performance won the teachers and students of trust and praise. I have strong governance capability, organize activities planning ability and interpersonal skills. Since 2001, I had been a year section student association President, once served as a monitor, vice President, school students committee and other job, as student cadre, I work earnestly, study hard, the result is outstanding, get school leadership, teachers and classmates unanimous approval and favorable comment of the, successively awarded "excellent league members", "miyoshi students" and "outstanding student cadres", city "outstanding student cadres" honorary title.
As normal, I especially attention to the basic skills, regularly can practice calligraphy, GangBiZi, chalk, basic solid, three pens brushstroke assessment all pass, Through hard work, I successfully passed the national putonghua grade exam, Chinese talents guide nets and excellent grades obtain certificate; secondary zeng, National computer level level examination results are excellent. College during my outstanding, the result is outstanding, judged first-class subsidies, second-class scholarship. As the stars of the school, I run the membership carefully writing, actively contribute, November 2004 obtain province "tao xingzhi essay" game third. 2005 glorious become joining the molecules.
The college, rich and colorful social life and sleek and nervous learning atmosphere, makes me get many different levels of exercise and test, Honesty and hard work is my principles, Calm and cool is my partys manner; The hobby widespread makes me very enrichment; Many friend makes me feel rich! I a strong sense of professionalism and responsibility enable me to face any difficulties and challenges.
As a graduate student, I'm not experienced may let you hesitated, but please trust me drive and efforts will compensate for this temporary shortage, maybe I'm not the best, but I definitely is the best effort. I believe: concentrate on certainly can win well!
"Good birds, then choose wood and habitat know already person and heartbeat." Let your eyes, open my life journey.
Thank you again for me, set aside time to read my ZiJianShu, wish you whether the work! Looking forward to your hope!
This salute!
