1，ND：YAG激光心肌再血管化远期效果实验研究，中华胸心外科杂志1996年10月第12卷第5期270。2，室间隔膜部瘤的外科治疗，西北国防医学杂志，1998年，7，19（2）126。3，常温心脏间隔缺损直视手术6例报告，西北国防医学杂志，1999，3，20（1）53。4，主动脉窦瘤破裂的外科治疗，西北国防医学杂志，2001，3，22（1）835，腋下小切口行动脉导管未闭结扎术体会，西北国防医学杂志，2001，9，22（3）227。6，二尖瓣替换术连续46例无死亡体会，西北国防医学杂志，2002，4，23（2）138。7,60例非体外循环冠状动脉旁路移植术临床总结, 西北国防医学杂志，2004,2,25(1)65。8,Cantrell综合征1例,西北国防医学杂志,2004,4,25(2)160。
《西北国防医学杂志》 是 中国科技核心期刊，但不是中文核心期刊。
算是 普通国家级期刊了。
用左旋T_4建立大鼠甲状腺功能亢进模型的实验研究--《西北国防医学杂志》2006年01期
本文献来源中国知网
目的:用含左旋T4的药物(优甲乐)灌胃建立大鼠甲状腺功能亢进(甲亢)模型。方法:每天以两种不同剂量(60μg/100g体重,30μg/100 g体重)的优甲乐灌胃,定期记录大鼠的心率(尾动脉脉搏)、收缩压、体重,放免法测定大鼠血清T3、T4。取大鼠心脏称重及HE染色做组织病理检查。结果:甲状腺功能亢进大鼠的血清T3、T4水平较对照组明显升高(P<0.01),该组动物的心率、心脏重量,心肌细胞大小也显著高于对照组(P<0.05)。结论:优甲乐是一种有效建立大鼠甲亢模型的药物。
【作者单位】：第四军医大学西京医院核医学科 陕西西安710032
【关键词】：甲状腺功能亢进;优甲乐;T3;T4
【分类号】：R-332
【DOI】：cnki:ISSN:1007-8622.0.2006-01-015
【正文快照】：
甲状腺功能亢进症(简称甲亢,HT,Hyperthy-roid ism)是一类由于血液中甲状腺激素(T3、T4)异常增高所导致的多系统高代谢症候群以及高兴奋症状。建立大鼠甲亢模型对基础研究意义重大,以往文献报道[1~3]用干甲状腺片建立甲亢大鼠模型所需时间普遍偏长(50 d左右),本文介绍一种相对
Objective: To establish the rat's hyperthyroidism model with Euthyrox containing L-T_4.Methods: Two different doses of Euthyrox were administered to rats by intragastric tube every day,rat's heart rate(caudal(artery) pulse),systolic pressure,and body weight were detected regularly and serum T_3、T_4 concentration were(determined) by radioimmunoassay.Rat's heart samples were removed,weighted and stained with HE to obtain the pathologic result of cardiac muscles.Results: The concentrations of serum total T_3 and T_4 were increased(remarkably) in those rats with hyperthyroidism(P<0.01).Compared to control group,the rat's heart rate,weight of heart and cardiac muscle cell's transverse diameter of the experimental group increased significantly(P <(0.05)).Conclusion: Euthyrox is an effective drug to establish rat's hyperthyroidism model.
代表性科研论文（*通讯作者）Yongmei Qi, Yingmei Zhang*, Yingxia Liu, Wenya Zhang. Nonylphenol decreases viability and arrests cell cycle via reactive oxygen species in Raji cells. Experimental and Toxicologic Pathology. 2011, doi:10.1016/j.etp.2011.06.002 （SCI）Yongmei Qi, Ailing Li, Dejun Huang, Yihong Tian, Yingmei Zhang*. Exogenous S-adenosyl-L-methionine could inhibit c-myc overexpression induced by As2O3 in normal human liver HL-7702 cells. Journal of Health Science. 2011, 57(2):188-191. (SCI)Yingxia Liu, Wenya Zhang, Xiaoning Zhang, Yongmei Qi, Dejun Huang and Yingmei Zhang*. Arsenic trioxide inhibits invasion/migration in SGC-7901 cells by activating the reactive oxygen species-dependent cyclooxygenase-2/matrix metalloproteinase-2 pathway. Experimental Biology and Medicine. 2011, 236: 592–597. (SCI)Wenya Zhang, Yingxia Liu, Zhen An, Dejun Huang, Yongmei Qi, Yingmei Zhang*. Mediating effect of ROS on mtDNA damage and low ATP content induced by arsenic trioxide in mouse oocytes. Toxicology in Vitro. 2011, 25(4):979-984. (SCI)Minyi Feng, Peng Chen, Xue Wei, Yingmei Zhang*, Wenya Zhang, Yongmei Qi. Effect of 4-nonylphenol on the sperm dynamic parameters, morphology and fertilization rate of Bufo raddei. African Journal of Biology. 2011, 10(14): 2698-2707. (SCI)Wantong Si, Weihong Ji, Feng Yang, Yue Lv, Yiming Wang, Dejun Huang, Yingmei Zhang*. The function of constructed wetland in reducing the risk of heavy metals on human health. Environmental Monitoring and Assessment, (DOI 10.1007s). 2011/1/5 Online first. (SCIE). (SCI).Li Su, Yuantao Deng, Yingmei Zhang*, et al. Protective Effects of grape seed proancyanidin extracts against nickel sulfate-induced apoptosis and oxidative stress in rat testes. Toxicology Mechanism and Methods. 2011, 21(6): 487-494. (SCI)Chuan Yan, Dejun Huang, Yingmei Zhang*. The involvement of ROS overproduction and mitochondrial dysfunction in PBDE-47-induced apoptosis on Jurkat cells. Experimental and Toxicologic Pathology. 2011, 63(5):413-417. (SCI)Tao Liu, Wenting He, Chuan Yan, Yongemi Qi, Yingmei Zhang*. Roles of reactive oxygen species and mitochondria in cadmium-induced injury of liver cells. Toxicology and Industrial Health. 2011, DOI: 10.1177 (SCI)Che Chen, Yingmei Zhang*, Yong Wang, Dejun Huang, Yaming Xi, Yongmei Qi. Synergic effect of 3'-azido-3'-deoxythymidine and arsenic trioxide in suppressing hepatoma cells. Anticancer Drugs 2011, 22(5):435-443. (SCI)Yimin Wang, Peng Chen, Ruina Cui, Wantong Si, Yingmei Zhang*, Weihong Ji. 2010. Heavy metal concentrations in water, sediment, and tissues of two fish species (Triplohysa pappenheimi, Gobio hwanghensis) from the Lanzhou section of the Yellow River, China. Environ Monit Assess. 165: 97-102. (SCI)Junling Wang, Yingmei Zhang*, Haojun Zhang, Ke Zhang, Zhewen Zhang, Jin Li. 2009. Toxic effects of fluoride on reproductive ability in male rats: sperm motility, oxidative stress, cell cycle, and testicular apoptosis. Fluoride. 42(3): 174-178. (SCI)Ming Jun Yang, Jing Wu, Zhong Duo Yang*, Ying Mei Zhang*. 2009. First total synthesis of paecilodepsipeptide A. Chinese Chemical Letters. 20: 527–530. (SCI)Gen Chen, Jie Qin, Dazhong Shi, Yingmei Zhang*, Weihong Ji. 2009. Diversity of soil nematodes in areas polluted with heavy metals and polycyclicaromatic hydrocarbons (PAHs) in Lanzhou, China. Environmental Management. 44: 163-172. (SCI)Wang YJ, Meng FG, Zhang YM*. 2009. Expression, purification and characterization of recombinant protein tyrosine phosphatase from Thermus thermophilus HB27. Acta Biochimica et Biophysica Sinica. 41: 689-698. (SCI)Huang DJ, Zhang YM*, Qi YM, Chen C, Ji WH. 2008. Global DNA hypomethylation, rather than reactive oxygen species (ROS), a potential facilitator of Cadmium-stimulated K562 cell proliferation. Toxicology Letters.179: 43-47. (SCI)Che Chen, Yingmei Zhang*, Yanchao Li, Huiyuan Chu, Yaming Xi. 2007. In vivo and in vitro anti-tumour response of selenium-protein polysaccharide extracted from rich selenium Agaricus blazei. Food and Agricultural Immunology. 18(2): 139-149. (SCI)Huang DJ, Zhang YM*, Song G, Long J, Liu JH, WH. Ji. 2007. Contaminants-induced oxidative damage on the carp Cyprinus carpio collected from the upper Yellow River, China. Environmental Monitoring and Assessment.128: 483-488. (SCI)Huang DJ, Zhang YM*, Wang YJ, Xie ZY, Ji WH. 2007. Assessment of the genotoxicity in toad Bufo raddei exposed to petrochemical contaminants in Lanzhou Region, China. Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 629 (2): 81-88. (SCI)Zhang YM*, Huang DJ, Zhao DQ, Long J, Song G, Li AN. 2007. Long-term toxicity effects of cadmium and lead on Bufo raddei tadpoles. Bulletin of Environmental Contamination and Toxicology. 79(2):178-183. (SCI)Yang Liu, Yingmei Zhang*, Jianghai Liu, Dejun Huang 2006 The role of reactive oxygen species in the herbicide acetochlor-induced DNA damage on Bufo raddei tadpole liver, Aquatic Toxicology , 78:21-26.（SCI）Y. Zhang*, L. Ruan, M. Fasola, E. Boncompagni, Y. Dong, N. Dai, C. Gandini, E. Orvini and X. Ruiz 2006 Little Egrets (Egretta Garzetta) and Trace-metal Contamination in Wetlands of China, Environmental Monitoring and Assessment,118:355-368. （SCI）Jianghai Liu, Yingmei Zhang*, Dejun Huang, Gang Song. 2005. Cadmium induced MTs synthesis via oxidative stress in yeast Saccharomyces cerevisiae, Mollecular and Cellular Biochemistry, 280:139-145.（SCI）Y. M. Zhang*, D. J. Huang, Y. Q. Wang, J. H. Liu, R. L. Yu, J. Long. 2005. Heavy Metal Accumulation and Tissue Damage in Goldfish Carassius auratus. Bulletin of Environmental Contamination and Toxicology, 75: 1191-1199.（SCI）S. Lambiase, Y. Zhang, P. Morbini, M. Fasola, G. Bernocchi, E. Roda,1 A. Grigolo. 2005. Tissue damage after acute intoxication by polychlorinated biphenyls (PCBs) in cockroaches Blattella germanica, European Journal of Histochemistry, 49:83-92.（SCI）Mauro Fasola, Paolo Galeotti, Nianhua Dai, Yuanhua Dong and Yingmei Zhang. 2004. Large Numbers of Breeding Egrets and Herons in China. Waterbirds. 27(1): 126-128. (SCI)Y.H.Dong, H.Wang, Q.An, X.Ruiz, M.Fasola & Y.M.Zhang. 2004. Residues of organochlorinated pesticides in eggs of water birds from Tai Lake in China. Environmental Geochemistry and Health, 26: 259-268.(SCI)Yingmei Zhang*, Luzhang Ruan, Dongqin Zhao, Yanhua Dong. 2002. The ecology of the Little Egret as a bioindicator for Tai Lake, China. 23rd International Ornithological Congress. Abstract Volume. 129, 187-188.Zhang YM, Lambiase S, Fasola M, Gandini C, Laudani U & Grigolo A. 2001. Mortality and Tissue Damage by Heavy Metal Contamination in the German Cockroach, Blattella germanica (Blattaria, Blattellidae). Ital. J.Zool. 68: 137-145.（SCI）Fasola M, Zhang Y, Zhao D, Dong Y, Wang H. 2001. Age-assortative mating related to reproductive success in Black-crowned Night Herons. Waterbirds. 24(2): 272-276.(SCI)Lambiase S, Conforti E, Fasola M, Grigolo A & Zhang YM. 2000. Fat body, gonads and prothoracic gland fate in adults of Blattella germanica L. (Blattaria: Blattellidae). Ital. J. Zool. 67: 245-254 (SCI)张宁，张迎梅*. 基于RS和GIS技术的尕海湿地景观变化趋势分析. 2011:10-14.严川，黄德军，李鹏道，张迎梅*. 2010. 多溴联苯醚对HL-7702细胞和小鼠皮肤成纤维细胞间隙连接通讯的影响. 西北师范大学学报(自然科学版), 46(3): 80-84.田永刚,张迎梅*.2010. 低剂量三聚氰胺对小鼠精子质量影响的研究. 四川动物, 29(3): 466-468.吕玥, 张迎梅*,杨峰, 司万童. 2010. 壬基酚对中华大蟾蜍蝌蚪的毒性效应. 农业环境科学学报, 29(6): 1086-1090.邴志桐, 李研超, 司万童, 张迎梅*. 2009. 阿特拉津对发育期SD大鼠免疫功能的影响. 兰州大学学报(自然科学版), 45(1): 56-59.张文雅,张迎梅*.2009. 氯氰菊酯通过食物链在鲤鱼肾脏和小肠中的生物积累效应.农业环境科学学报，28(8): 1640-1644.李瑷伶, 蓝昕, 司万童, 邴志桐, 黄德军, 张迎梅*. 2008. 己烯雌酚对染镉草鱼GSH-Px、SOD和MDA影响的研究. 农业环境科学学报, 27(1): 350-353.张迎梅*, 王叶菁, 虞闰六, 周敏. 2008. 重金属胁迫对泥鳅肝胰脏ATPase和SOD活性的影响. 甘肃科学学报, 20(3): 55-59.司万童,张迎梅*,李瑷伶, 蓝昕, 黄德军. 2008. 已烯雌酚对蝌蚪抗敌敌畏诱导氧化损伤的作用研究. 甘肃科学学报, 20(01): 51-54.李安娜, 张迎梅*,李瑷伶, 周敏, 陈鹏. 2008. 十二烷基硫酸钠对斑马鱼抗氧化能力的影响. 四川动物, 27(6): 993-996.任培丽, 张迎梅*,耿广琴, 漆永梅. 2008. 污染水域鲫鱼外周血细胞形态和数量的变化. 动物学杂志, 43(2):37-42.张迎梅, 包新康, 张立勋, 黄德军. 2008. 动物生物学实验改革与创新性人才培养. 高等理科教育. 78: 55-57.宋刚, 张迎梅*,朱丽娜, 侯亚妮, 谢卓艺. 2007. 黄河上游环境污染对花背蟾蜍抗氧化酶活性及丙二醛含量的影响. 四川动物, 2007年 2期.谭玉凤, 张迎梅*,王丙莲, 龙静, 黄德军, 刘江海. 2006. 亚硒酸钠染毒对小鼠免疫功能的影响. 环境与职业医学, 23(1): 38-40.王丙莲, 张迎梅*,侯亚妮, 宋刚, 谭玉凤. 2006. 镉铅对泥鳅转氨酶活性的影响. 兰州大学学报, 42(3): 67-70.罗松年, 张迎梅*,任培丽. 2006. 低剂量镉诱导细胞氧化损伤的机理研究. 安全与环境学报, 6(3): 77-79.张迎梅, 王叶菁, 虞闰六, 张晟, 吴振斌. 2006. 重金属Cd、Pb和Zn对泥鳅DNA 损伤的研究. 水生生物学报, 30(4): 399-403.王丙莲, 张迎梅*, 谭玉凤, 候亚妮, 刘阳. 2006. 镉铅对泥鳅DNA甲基化水平的影响. 毒理学杂志, 20: 78-80.龙静, 张迎梅*, 朱丽娜, 黄德军, 宋刚. 2006. 利用微核试验和彗星电泳试验评价黄河兰州段水质致遗传毒性作用. 应用与环境生物学报, 12: 59-63包新康, 张健, 曲扎, 张迎梅*. 2005. 拉萨拉鲁湿地夏季鸟类调查初报. 动物学杂志, 40(2): 86-89.谭玉凤,张迎梅*. 2005. 铅污染对机体健康的影响. 西北国防医学杂志, 26: 132-134.张迎梅, 刘亚军, 张文定, 张正国. 2005. 积极稳妥，效果优先，推进双语教学课程建设. 高等理科教育, 63: 48-50.张正国, 张迎梅, 张文定. 2005. 强化精品意识 创建精品课程. 高等理科教育, 60: 51-53.教材编写.吴诗宝, 刘乃发, 张迎梅, 马广智. 2004. 中国穿山甲受危状况评估. 应用与环境生物学报, 10(4): 456-461.安琼, 董元华, 王辉, 李运东, 葛方龙, Fasola M, Ruiz Xavier, 张迎梅. 2004. 不同年龄夜鹭卵中有机氯农药污染的生物指示. 环境科学学报, 24(1): 110-113.黄德军, 张迎梅*, 赵东芹, 龙静, 汪贵英, 胡之德. 2004. 重金属镉对花背蟾蜍蝌蚪生长的影响. 兰州大学学报, 40(2): 81-83.龙静, 张迎梅*,赵东芹, 汪贵英, 胡之德. 2004. 铅对花背蟾蜍受精卵出膜及蝌蚪生长的影响. 甘肃科学学报, 16(2): 47-49.张迎梅, 包新康, 高岚. 2004. 《动物生物学实验指导》(双语), 兰州大学出版社.王银秋, 张迎梅*,赵东芹. 2003. 重金属镉、铅、锌对鲫鱼和泥鳅的毒性. 甘肃科学学报, 15(1): 35-38.包新康, 马建章, 张迎梅*. 2003. 大兴安岭紫貂食物组成分析. 兽类学报, 23(3): 203-207.阮禄章, 张迎梅*,赵东芹, 董元华, Fasola Mauro. 2003. 白鹭作为无锡地区环境污染指示生物的研究. 应用生态学报, 14(2): 263-268.张迎梅, 赵东芹, 阮禄章, 董元华, 王辉, M Fasola. 2003. 太湖地区夜鹭配对年龄及繁殖效果. 动物学研究, 24(1): 57-59.张迎梅. 2003. “动物生物学”开展双语教学的几点体会, 高等理科教育, 1: 67-68.张迎梅, 陈强. 2003. “流动式”生物学野外实习探索与实践, 高等理科教育.虞闰六, 张迎梅*,包新康, 李新荣. 2002. 宁夏沙坡头地区环境结构变化与鸟类生物多样性. 兰州大学学报, 38(6): 78-83.张迎梅, 包新康, 虞闰六, 李新荣. 2002. 宁夏沙坡头荒漠生态环境鸟类季节性消长研究. 中国沙漠, 22(6): 541-544.王辉, 董元华, 李涛, 张迎梅, 阮禄章, 赵东芹, Fasola M. 2002. 无锡鼋头渚4种鹭类繁殖期的生态学特征研究. 农村生态环境, 17(4): 17-21.龚钟明, 董元华, 安琼, 王辉, 李运东, 阮禄章, 张迎梅, Fasola M. 2001. 无锡鼋头渚夜鹭卵中有机氯农药残留及其环境指示意义. 环境科学, 22(2): 110-113.张迎梅, 阮禄章, 董元华, 龚钟明, 李运东, 王辉, Fasola Mauro. 2000. 无锡太湖地区夜鹭及白鹭繁殖生物学研究. 动物学研究, 21(4): 275-278参与和主编出版专著参与编写出版的专著主要有《宁夏脊椎动物志》（1990年，宁夏人民出版社）、《甘肃脊椎动物志》（1991年，甘肃科学技术出版社）、《甘肃兴隆山国家级自然保护区资源本地调查研究》（1996年，甘肃民族出版社），主编出版了《动物生物学实验指导》（2004年，兰州大学出版社）。
