In the knowledge economy era, knowledge becomes the most important factor of production; technology, patents, creative and other software products has become an important product form. Knowledge become the dominant consumer consumption; knowledge as factors of production and distribution. Possession of the degree of knowledge as the main basis for the allocation, with the knowledge, creative workers become the main employment; high-tech industry will become the pillar industry of the era of knowledge economy; innovation is the soul of the knowledge economy. Knowledge-based economy era is bound to have an enormous impact on international structure of international trade, the impact of commodity: In the knowledge economy era, the invisible trade will be the main content of international trade. Knowledge-based economy era, will make the world trade liberalization was accelerated. Integration of domestic and foreign markets, no longer be divided into domestic and foreign trade, market competition has become a global competition. The rapid development of regional blocs is a manifestation of the trend of trade words knowledge-based economy; international trade; impact; countermeasures