找到一篇： 【正题名】: Synthesis and characterization of pH- and temperature-sensitive poly(methacrylic acid)/poly(N-isopropylacrylamide) interpenetrating polymeric networks 【作者】: Zhang J; Peppas NA 【作者单位】:Purdue Univ, Sch Chem Engn, W Lafayette, IN 47907, USA, 【刊名】: Macromolecules 【年卷期】: V33,N1,2000 【出版年】: 2000 【ISSN】: 0024-9297 【页码】: 102-107 【分类号】: O6; O62 【关键词】: Poly(n-isopropylacrylamide-co-methacrylic acid) hydrogels; Thermosensitive hydrogels; N-isopropylacrylamide; Drug release; Kinetics; Water; Dependence; Delivery; Behavior; Surface 【正文语种】: Eng 【文摘】:Hydrogels of an interpenetrating polymeric network (IPN) composed of the temperature-sensitive poly(N-isopropylacrylamide) (PNIPAAm) and the pH-sensitive poly(methacrylic acid) (PMAA) were prepared by a sequential UV polymerization The IPN hydrogels were characterized for their temperature- and pH-responsive behavior by equilibrium swelling studies, oscillatory swelling studies, and differential scanning The permeability of these IPNs has been investigated under various pH and temperature The results showed that these hydrogels exhibited a combined pH- and temperature-sensitivity at a temperature range of 31-32 degrees C and a pH value of approximately Permeation study results indicate a significant size exclusion behavior while model drugs with different sizes permeate through the IPN The permeability of the IPN membrane can be significantly affected by varying the pH and temperature [References: 29] 全文请与“中国科技文献情报中心”（北京）联系，他们可以帮助复制。
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