Penicillin was QingMeiJun in fermentation metabolic process of secondary metabolites. Penicillin production is to determine the production capacity of strains, and internal factors in the process of fermentation process adjustment control, equipment structure, dynamic conditions, such as quality of raw material, which is the growth of bacteria, biosynthesis of environmental conditions. Both at home and abroad, to improve the general level of penicillin fermentation, reduce the consumption and manufacturing cost, it is to be in "breeding high strain and reform process, equipment and dynamic conditions", etc in test, research, seeking high yield, high. Therefore in the eighth five-year plan for national public projects, to solve the key technical problems are: 1) high strain breeding penicillin, 2 penicillin high technology research, Three new developed. Stir fermentation, Our team around the three aspects of the technology in public. In the us, including breeding in protoplast fusion had done the experiment, cross breeding methods, but according to what we have human, material conditions, main or mutation breeding and natural separation method combining. First, we examine the mutagen screening for more effective, QingMeiJun chemical compound processing factors, Secondly according to production conditions change, in order to ensure the filter is used to produce the strains of promotion. Through more than a screening and treatment, the application of mathematical statistic method, the scientific analysis of the test results obtained 18-26-93 high-yield mutations. Not only the original plant production capacity increase. And the result of rheological properties, matrix are superior to the strains (fermented liquid viscosity, matrix increased).In the process of research, the mathematical statistical method, with the unit price for the change of time validity, other parameters for the independent variables, the production of large and test data analysis. We recognize the appropriate process control is fully exert important means of inner potential strains. Green is a complicated mould fermentation process of many factors control engineering. Which is more strains in the metabolism of pH and the comprehensive reflection of factors, the balance of sugar is main control factors, process control, and we know that in different strains of equipment or oxygen condition should be adapted to the process and to show the potential. We have established a set of "flexible" mode, the practical process of change in the appropriate means of control, the dynamic process control to ensure the production management level of improving steadily. QingMeiJun aerobic bacteria, it is growing metabolism, synthesis of penicillin are required to have sufficient oxygen supply. For in the existing air supply under the condition of limited and mixing power under improve dissolved oxygen levels, can be improved by optimizing the purpose of mixing system. We use mechanics, fluid mechanics, from the current situation analysis, to improve gas bubbles, decentralized state liquid oxygen forms of exercise to improve the ability to target. Through the analysis and field tests, radial flow and axial flow from mixing, the advantages and disadvantages of the shaft, design, runoff and mixing combination of big height more air orientation wing of the tooth chip mixing system combined. Such a stir the mixture kettle, good effect, the current slightly lower, the air flow is not the circumstance, improve dissolved oxygen levels.